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Two Sigma Advisers

Two Sigma Advisers Portfolio holdings

AUM $51.4B
1-Year Est. Return 31.07%
This Fund
S&P 500
This Quarter Est. Return
-3%
1 Year Est. Return
+31.07%
3 Year Est. Return
+128.94%
5 Year Est. Return
+161.75%
10 Year Est. Return
+607.04%
AUM
$44.4B
AUM Growth
+$1.2B
Cap. Flow
+$3.32B
Cap. Flow %
7.48%
Top 10 Hldgs %
17.65%
Holding
2,641
New
312
Increased
1,037
Reduced
994
Closed
281

Top Buys

Rank Stock Value
1
AVGO icon
Broadcom
AVGO
+$519M
2
CRM icon
Salesforce
CRM
+$460M
3
REGN icon
Regeneron Pharmaceuticals
REGN
+$381M
4
BSX icon
Boston Scientific
BSX
+$347M
5
ISRG icon
Intuitive Surgical
ISRG
+$319M

Top Sells

Rank Stock Value
1
V icon
Visa
V
+$555M
2
LLY icon
Eli Lilly
LLY
+$536M
3
META icon
Meta Platforms (Facebook)
META
+$433M
4
PGR icon
Progressive
PGR
+$330M
5
LRCX icon
Lam Research
LRCX
+$294M

Sector Composition

Rank Sector Weight
1 Technology 25.86%
2 Healthcare 15.38%
3 Financials 14.3%
4 Consumer Discretionary 11.43%
5 Industrials 10.56%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CIM
776
Chimera Investment
CIM
$1.06B
$5.2M 0.01%
405,528
+146,700
+57% +$2.06M
SNA icon
777
Snap-on
SNA
$21.7B
$5.19M 0.01%
15,400
+8,400
+120% +$2.85M
KRC icon
778
Kilroy Realty
KRC
$4.5B
$5.19M 0.01%
158,300
+44,100
+39% +$1.58M
ITCI
779
DELISTED
Intra-Cellular Therapies Inc.
ITCI
$5.14M 0.01%
38,967
-104,300
-73% -$13M
QGEN icon
780
Qiagen
QGEN
$8.72B
$5.13M 0.01%
127,854
-63,783
-33% -$2.68M
VRN
781
DELISTED
Veren
VRN
$5.13M 0.01%
775,036
+499,639
+181% +$2.76M
EPR icon
782
EPR Properties
EPR
$4.92B
$5.13M 0.01%
97,500
+71,400
+274% +$3.5M
BXSL icon
783
Blackstone Secured Lending
BXSL
$5.43B
$5.1M 0.01%
+157,589
New +$5.2M
TEVA icon
784
Teva Pharmaceuticals
TEVA
$36.9B
$5.1M 0.01%
331,500
-1,299,100
-80% -$23.2M
VST icon
785
Vistra
VST
$50.1B
$5.08M 0.01%
43,285
+12,769
+42% +$1.91M
XERS icon
786
Xeris Biopharma Holdings
XERS
$1.42B
$5.08M 0.01%
925,615
+911,874
+6,636% +$3.68M
CLS icon
787
Celestica
CLS
$40.3B
$5.07M 0.01%
64,376
-76,300
-54% -$8.09M
CRL icon
788
Charles River Laboratories
CRL
$11.6B
$5.06M 0.01%
33,600
+5,500
+20% +$922K
ZTS icon
789
Zoetis
ZTS
$32.5B
$5.05M 0.01%
30,700
-9,200
-23% -$1.53M
CIB icon
790
Grupo Cibest SA
CIB
$21.1B
$5.05M 0.01%
125,700
+84,900
+208% +$3.33M
KYMR icon
791
Kymera Therapeutics
KYMR
$8.73B
$5.02M 0.01%
183,300
-77,000
-30% -$2.81M
OCSL icon
792
Oaktree Specialty Lending
OCSL
$1.06B
$4.99M 0.01%
325,041
-44,900
-12% -$704K
HRB icon
793
H&R Block
HRB
$5.7B
$4.99M 0.01%
+90,900
New +$4.86M
ANAB icon
794
AnaptysBio
ANAB
$1.54B
$4.98M 0.01%
268,100
-25,200
-9% -$420K
AEG icon
795
Aegon
AEG
$13.6B
$4.97M 0.01%
754,595
+471,388
+166% +$3.01M
WEAV icon
796
Weave Communications
WEAV
$548M
$4.96M 0.01%
447,100
-149,200
-25% -$2.14M
GES
797
DELISTED
Guess Inc
GES
$4.96M 0.01%
447,802
+159,800
+55% +$1.93M
CYH icon
798
Community Health Systems
CYH
$393M
$4.95M 0.01%
1,833,655
-160,400
-8% -$499K
MRVI icon
799
Maravai LifeSciences
MRVI
$1.01B
$4.95M 0.01%
2,238,000
+2,021,500
+934% +$7.99M
VTS icon
800
Vitesse Energy
VTS
$626M
$4.91M 0.01%
199,800
-22,300
-10% -$571K
30 31
32
33 34

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Two Sigma Advisers's Q1 2025 Portfolio in Review

As of Q1 2025, Two Sigma Advisers held 2,641 positions worth $44.4B, up 2.8% from $43.2B the previous quarter. Its ten largest holdings account for 18% of the portfolio.

Two Sigma Advisers deployed $3.32B of net new capital in Q1 2025, opening 312 new positions and adding to 1,037 existing holdings. Its largest new stake was Regeneron Pharmaceuticals: 553,800 shares worth $351M.

By sector, the portfolio is most concentrated in Technology at 26% of assets, up from 25% a quarter earlier, followed by Healthcare and Financials.

On the sell side, the largest reduction was Visa, an estimated $555M trimmed.

  • Two Sigma Advisers's largest Q1 2025 buy was Regeneron Pharmaceuticals: 553,800 shares worth $351M.
  • Two Sigma Advisers added most to Broadcom in Q1 2025, an estimated $519M increase.
  • Two Sigma Advisers's biggest Q1 2025 reduction was Visa, cutting an estimated $555M.
  • Two Sigma Advisers fully exited Abbott in Q1 2025, selling an estimated $158M.
  • Two Sigma Advisers's ten largest holdings make up 18% of its $44.4B portfolio in Q1 2025.
  • Two Sigma Advisers opened 312 new positions and closed 281 in Q1 2025.
  • Two Sigma Advisers's portfolio value rose 2.8% quarter-over-quarter to $44.4B.

Based on Two Sigma Advisers's 13F filing for Q1 2025, filed 15 May 2025.