Two Sigma Advisers
KZR

Two Sigma Advisers’s Kezar Life Sciences KZR Stock Holding History

Two Sigma Advisers’s Portfolio KZR Stock Details KZR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-54,261
Closed -$212K – 2489
2025
Q3 		$212K Sell
54,261
-380
-0.7% -$1.56K ﹤0.01% 2115
2025
Q2 		$250K Sell
54,641
-9,868
-15% -$42.3K ﹤0.01% 2033
2025
Q1 		$315K Sell
64,509
-35,632
-36% -$216K ﹤0.01% 1970
2024
Q4 		$673K Sell
100,141
-40,149
-29% -$299K ﹤0.01% 1650
2024
Q3 		$1.08M Buy
140,290
+16,530
+13% +$99.7K ﹤0.01% 1375
2024
Q2 		$743K Buy
123,760
+580
+0.5% +$4.41K ﹤0.01% 1707
2024
Q1 		$1.11M Sell
123,180
-9,050
-7% -$82.4K ﹤0.01% 1540
2023
Q4 		$1.25M Buy
132,230
+65,240
+97% +$573K ﹤0.01% 1532
2023
Q3 		$797K Sell
66,990
-20,740
-24% -$368K ﹤0.01% 1614
2023
Q2 		$2.15M Buy
87,730
+35,170
+67% +$916K 0.01% 1160
2023
Q1 		$1.65M Buy
52,560
+14,590
+38% +$844K ﹤0.01% 1374
2022
Q4 		$2.67M Sell
37,970
-9,300
-20% -$690K 0.01% 1082
2022
Q3 		$4.07M Sell
47,270
-18,210
-28% -$1.77M 0.01% 837
2022
Q2 		$5.42M Buy
65,480
+15,530
+31% +$1.37M 0.02% 735
2022
Q1 		$8.3M Sell
49,950
-1,230
-2% -$177K 0.02% 593
2021
Q4 		$8.56M Buy
51,180
+23,010
+82% +$2.6M 0.02% 555
2021
Q3 		$2.43M Buy
28,170
+6,910
+33% +$457K 0.01% 1144
2021
Q2 		$1.15M Sell
21,260
-3,870
-15% -$220K ﹤0.01% 1571
2021
Q1 		$1.5M Sell
25,130
-3,530
-12% -$206K ﹤0.01% 1418
2020
Q4 		$1.5M Sell
28,660
-1,460
-5% -$81.2K ﹤0.01% 1398
2020
Q3 		$1.46M Buy
30,120
+20,090
+200% +$961K ﹤0.01% 1327
2020
Q2 		$520K Buy
10,030
+3,620
+56% +$183K ﹤0.01% 1869
2020
Q1 		$279K Buy
6,410
+1,370
+27% +$55.7K ﹤0.01% 2042
2019
Q4 		$202K Sell
5,040
-1,300
-21% -$40K ﹤0.01% 2187
2019
Q3 		$208K Buy
+6,340
New +$306K ﹤0.01% 2031

Other funds holding KZR

BCM
BML Capital Management Zionsville, Indiana $176M AUM 123.21% 1-Year Est. Return
SCM
Suvretta Capital Management New York $3.92B AUM 86.67% 1-Year Est. Return
TCM
Tang Capital Management San Diego, California $1.97B AUM 125.1% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
NCM
Nantahala Capital Management New Canaan, Connecticut $2.72B AUM 121.58% 1-Year Est. Return
AAA
Affinity Asset Advisors New York $2.21B AUM 431.26% 1-Year Est. Return
SCM
Stonepine Capital Management Bend, Oregon $250M AUM 77.6% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $72.6B AUM 54.88% 1-Year Est. Return
PLC
Peapod Lane Capital Bedford Hills, New York $148M AUM 89.92% 1-Year Est. Return
Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $84.2B AUM 55.88% 1-Year Est. Return

Two Sigma Advisers's KZR Position: Q4 2025 in Review

Two Sigma Advisers sold out of Kezar Life Sciences (KZR) in Q4 2025, closing a stake of 54,261 shares — an estimated $212K sold.

Two Sigma Advisers first reported a position in KZR in Q3 2019 and held it in 25 quarters. The position peaked at $8.56M in Q4 2021. 43 funds tracked by Wall St. Rank hold KZR as of Q4 2025.

  • Two Sigma Advisers reported no remaining Kezar Life Sciences position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 54,261 Kezar Life Sciences shares in Q4 2025, an estimated $212K.
  • Two Sigma Advisers first reported a position in Kezar Life Sciences in Q3 2019 and held it in 25 quarters.
  • Two Sigma Advisers's Kezar Life Sciences position peaked at $8.56M in Q4 2021.
  • 43 funds tracked by Wall St. Rank held Kezar Life Sciences as of Q4 2025.

Based on Two Sigma Advisers's 13F filing for Q4 2025, filed 17 Feb 2026.