Two Sigma Advisers
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Two Sigma Advisers’s Amphastar Pharmaceuticals AMPH Stock Holding History

Two Sigma Advisers’s Portfolio AMPH Stock Details AMPH Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-22,800
Closed -$608K – 2341
2025
Q3 		$608K Sell
22,800
-72,400
-76% -$1.87M ﹤0.01% 1684
2025
Q2 		$2.19M Buy
95,200
+10,500
+12% +$261K ﹤0.01% 1079
2025
Q1 		$2.46M Sell
84,700
-1,200
-1% -$38.3K 0.01% 1076
2024
Q4 		$3.19M Sell
85,900
-12,400
-13% -$567K 0.01% 900
2024
Q3 		$4.77M Sell
98,300
-7,800
-7% -$342K 0.01% 717
2024
Q2 		$4.24M Sell
106,100
-19,800
-16% -$820K 0.01% 837
2024
Q1 		$5.53M Sell
125,900
-1,500
-1% -$77.5K 0.01% 741
2023
Q4 		$7.88M Buy
127,400
+42,000
+49% +$2.21M 0.02% 629
2023
Q3 		$3.93M Buy
85,400
+12,800
+18% +$698K 0.01% 860
2023
Q2 		$4.17M Buy
72,600
+13,500
+23% +$598K 0.01% 848
2023
Q1 		$2.22M Sell
59,100
-21,300
-26% -$698K 0.01% 1223
2022
Q4 		$2.25M Sell
80,400
-10,200
-11% -$296K 0.01% 1175
2022
Q3 		$2.55M Sell
90,600
-20,800
-19% -$679K 0.01% 1052
2022
Q2 		$3.88M Buy
111,400
+87,700
+370% +$3.13M 0.01% 879
2022
Q1 		$851K Buy
23,700
+6,200
+35% +$176K ﹤0.01% 1723
2021
Q4 		$408K Buy
17,500
+900
+5% +$18.4K ﹤0.01% 2009
2021
Q3 		$316K Sell
16,600
-800
-5% -$15.7K ﹤0.01% 2096
2021
Q2 		$351K Sell
17,400
-21,200
-55% -$399K ﹤0.01% 2085
2021
Q1 		$707K Sell
38,600
-2,900
-7% -$53.9K ﹤0.01% 1843
2020
Q4 		$835K Sell
41,500
-115,600
-74% -$2.25M ﹤0.01% 1651
2020
Q3 		$2.95M Buy
+157,100
New +$3.16M 0.01% 973
2019
Q4 		– Sell
-22,300
Closed -$442K – 2344
2019
Q3 		$442K Sell
22,300
-12,600
-36% -$262K ﹤0.01% 1766
2019
Q2 		$737K Buy
34,900
+10,200
+41% +$213K ﹤0.01% 1656
2019
Q1 		$505K Buy
24,700
+10,900
+79% +$244K ﹤0.01% 1796
2018
Q4 		$275K Buy
+13,800
New +$272K ﹤0.01% 2022
2018
Q2 		– Sell
-12,200
Closed -$229K – 2349
2018
Q1 		$229K Buy
+12,200
New +$229K ﹤0.01% 2105
2017
Q4 		– Sell
-10,300
Closed -$184K – 2230
2017
Q3 		$184K Sell
10,300
-3,000
-23% -$49.3K ﹤0.01% 2068
2017
Q2 		$238K Sell
13,300
-47,400
-78% -$752K ﹤0.01% 2065
2017
Q1 		$880K Sell
60,700
-27,500
-31% -$432K ﹤0.01% 1650
2016
Q4 		$1.63M Sell
88,200
-15,400
-15% -$300K 0.01% 1290
2016
Q3 		$1.97M Sell
103,600
-13,100
-11% -$238K 0.01% 1031
2016
Q2 		$1.88M Sell
116,700
-5,300
-4% -$74.8K 0.01% 889
2016
Q1 		$1.46M Buy
122,000
+3,562
+3% +$42K 0.01% 944
2015
Q4 		$1.69M Sell
118,438
-7,864
-6% -$104K 0.01% 804
2015
Q3 		$1.5M Sell
126,302
-48,399
-28% -$726K 0.01% 832
2015
Q2 		$3.07M Buy
174,701
+149,601
+596% +$2.33M 0.02% 643
2015
Q1 		$375K Buy
+25,100
New +$335K ﹤0.01% 1478

Other funds holding AMPH

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
TD Asset Management
TD Asset Management Toronto, Ontario, Canada $123B AUM 34.51% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
Fuller & Thaler Asset Management
Fuller & Thaler Asset Management San Mateo, California $29.7B AUM 43.33% 1-Year Est. Return
Marshall Wace
Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return
EIP
Epoch Investment Partners New York $16.5B AUM 24.3% 1-Year Est. Return
BTW
Boston Trust Walden Boston, Massachusetts $12.2B AUM 12.45% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Two Sigma Advisers's AMPH Position: Q4 2025 in Review

Two Sigma Advisers sold out of Amphastar Pharmaceuticals (AMPH) in Q4 2025, closing a stake of 22,800 shares — an estimated $608K sold.

Two Sigma Advisers first reported a position in AMPH in Q1 2015 and held it in 37 quarters. The position peaked at $7.88M in Q4 2023. 235 funds tracked by Wall St. Rank hold AMPH as of Q4 2025.

  • Two Sigma Advisers reported no remaining Amphastar Pharmaceuticals position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 22,800 Amphastar Pharmaceuticals shares in Q4 2025, an estimated $608K.
  • Two Sigma Advisers first reported a position in Amphastar Pharmaceuticals in Q1 2015 and held it in 37 quarters.
  • Two Sigma Advisers's Amphastar Pharmaceuticals position peaked at $7.88M in Q4 2023.
  • 235 funds tracked by Wall St. Rank held Amphastar Pharmaceuticals as of Q4 2025.

Based on Two Sigma Advisers's 13F filing for Q4 2025, filed 17 Feb 2026.