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Stonepine Capital Management Portfolio holdings

AUM $177M
1-Year Est. Return 91.13%
This Fund
S&P 500
This Quarter Est. Return
+20.81%
1 Year Est. Return
+91.13%
3 Year Est. Return
+230.7%
5 Year Est. Return
+260.67%
10 Year Est. Return
+2,169.5%
AUM
$137M
AUM Growth
+$14M
Cap. Flow
+$1.59M
Cap. Flow %
1.16%
Top 10 Hldgs %
53.02%
Holding
89
New
31
Increased
13
Reduced
18
Closed
23

Top Buys

Rank Stock Value
1
CRBP icon
Corbus Pharmaceuticals
CRBP
+$4.81M
2
KZIA
Kazia Therapeutics
KZIA
+$3.92M
3
IKT icon
Inhibikase Therapeutics
IKT
+$2.57M
4
ACET icon
Adicet Bio
ACET
+$2.43M
5
HELP
Cybin Inc
HELP
+$2.19M

Top Sells

Rank Stock Value
1
DAWN
Day One Biopharmaceuticals
DAWN
+$3.74M
2
ENTA icon
Enanta Pharmaceuticals
ENTA
+$2.6M
3
OABI icon
OmniAb
OABI
+$2.51M
4
ZVRA icon
Zevra Therapeutics
ZVRA
+$2.28M
5
SRZN icon
Surrozen
SRZN
+$2.21M

Sector Composition

Rank Sector Weight
1 Healthcare 92.31%
2 Miscellaneous 7.69%
3 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
VSTM icon
1
Verastem
VSTM
$723M
$21.1M 15.4%
2,732,079
+62,047
+2% +$553K
ADMA icon
2
ADMA Biologics
ADMA
$2.15B
$13.5M 9.85%
740,000
+1,000
+0.1% +$16.9K
EOLS icon
3
Evolus
EOLS
$598M
$10.9M 7.92%
1,631,588
+95,197
+6% +$645K
ZVRA icon
4
Zevra Therapeutics
ZVRA
$745M
$5.1M 3.72%
569,088
-240,912
-30% -$2.28M
IKT icon
5
Inhibikase Therapeutics
IKT
$352M
$4.81M 3.51%
2,348,147
+1,613,128
+219% +$2.57M
ABEO icon
6
Abeona Therapeutics
ABEO
$339M
$3.74M 2.73%
709,505
+258,535
+57% +$1.3M
NKTR icon
7
Nektar Therapeutics
NKTR
$2.61B
$3.59M 2.62%
85,000
– –
INDV icon
8
Indivior Pharmaceuticals
INDV
$4.11B
$3.59M 2.62%
100,000
– –
CRBP icon
9
Corbus Pharmaceuticals
CRBP
$222M
$3.17M 2.32%
+389,916
New +$4.81M
KZIA
10
Kazia Therapeutics
KZIA
$189M
$3.17M 2.32%
+460,359
New +$3.92M
XOMA
11
DELISTED
Xoma
XOMA
$3.06M 2.23%
115,000
-459
-0.4% -$14.8K
VRCA icon
12
Verrica Pharmaceuticals
VRCA
$92.1M
$2.94M 2.15%
+353,669
New +$1.96M
HELP
13
Cybin Inc
HELP
$860M
$2.78M 2.03%
+339,902
New +$2.19M
TELA icon
14
TELA Bio
TELA
$35.1M
$2.78M 2.03%
2,352,032
+196,513
+9% +$249K
ACAD icon
15
Acadia Pharmaceuticals
ACAD
$4.8B
$2.67M 1.95%
100,000
-74,544
-43% -$1.78M
CRSP icon
16
CALL
CRISPR Therapeutics
CRSP
$5.46B
$2.62M 1.91%
+50,000
New +$2.99M
SRZN icon
17
Surrozen
SRZN
$265M
$2.57M 1.87%
113,631
-136,515
-55% -$2.21M
ARE icon
18
CALL
Alexandria Real Estate Equities
ARE
$9.07B
$2.45M 1.79%
+50,000
New +$2.94M
XFOR icon
19
X4 Pharmaceuticals
XFOR
$401M
$2.37M 1.73%
593,573
-462,765
-44% -$1.68M
RARE icon
20
CALL
Ultragenyx Pharmaceutical
RARE
$1.46B
$2.3M 1.68%
+100,000
New +$3.29M
AYTU icon
21
AYTU BioPharma
AYTU
$24.5M
$2.12M 1.54%
813,704
-78,151
-9% -$175K
NKTR icon
22
CALL
Nektar Therapeutics
NKTR
$2.61B
$2.11M 1.54%
+50,000
New +$2.8M
DAWN
23
DELISTED
Day One Biopharmaceuticals
DAWN
$1.86M 1.36%
200,000
-447,382
-69% -$3.74M
ACET icon
24
Adicet Bio
ACET
$88.3M
$1.85M 1.35%
+220,011
New +$2.43M
SPRB
25
Spruce Biosciences
SPRB
$166M
$1.72M 1.26%
+19,742
New +$2.12M
1
2 3 4

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MSA
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HF
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BFAG
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CWP
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Stonepine Capital Management's Q4 2025 Portfolio in Review

As of Q4 2025, Stonepine Capital Management held 89 positions worth $137M, up 11% from $123M the previous quarter. Its ten largest holdings account for 53% of the portfolio.

Stonepine Capital Management's Q4 2025 filing shows 31 new, 13 increased, 18 reduced and 23 closed positions. Its largest new stake was Corbus Pharmaceuticals: 389,916 shares worth $3.17M. The largest sale was Day One Biopharmaceuticals, an estimated $3.74M.

By sector, the portfolio is most concentrated in Healthcare at 92% of assets, down from 100% a quarter earlier, followed by Miscellaneous and Financials.

  • Stonepine Capital Management's largest Q4 2025 buy was Corbus Pharmaceuticals: 389,916 shares worth $3.17M.
  • Stonepine Capital Management added most to Inhibikase Therapeutics in Q4 2025, an estimated $2.57M increase.
  • Stonepine Capital Management's biggest Q4 2025 reduction was Day One Biopharmaceuticals, cutting an estimated $3.74M.
  • Stonepine Capital Management fully exited Soleno Therapeutics in Q4 2025, selling an estimated $1.62M.
  • Stonepine Capital Management's ten largest holdings make up 53% of its $137M portfolio in Q4 2025.
  • Stonepine Capital Management opened 31 new positions and closed 23 in Q4 2025.
  • Stonepine Capital Management's portfolio value rose 11% quarter-over-quarter to $137M.

Based on Stonepine Capital Management's 13F filing for Q4 2025, filed 13 Feb 2026.