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SSC

Spruce Street Capital Portfolio holdings

AUM $510M
This Fund
S&P 500
This Quarter Est. Return
+28.8%
1 Year Est. Return
–
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$510M
AUM Growth
+$93.7M
Cap. Flow
+$9.18M
Cap. Flow %
1.8%
Top 10 Hldgs %
70.24%
Holding
33
New
5
Increased
8
Reduced
1
Closed
3

Top Buys

Rank Stock Value
1
IFRX icon
InflaRx
IFRX
+$10.1M
2
ALKS icon
Alkermes
ALKS
+$8.82M
3
KNSA icon
Kiniksa Pharmaceuticals
KNSA
+$8.14M
4
ZLAB icon
Zai Lab
ZLAB
+$5.51M
5
RACC
Research Alliance Corp III
RACC
+$5.21M

Top Sells

Rank Stock Value
1
CNTA
Centessa Pharmaceuticals
CNTA
+$19.5M
2
KALV
KalVista Pharmaceuticals
KALV
+$18.1M
3
MAZE
Maze Therapeutics
MAZE
+$5.97M
4
DNTH icon
Dianthus Therapeutics
DNTH
+$1.61M

Sector Composition

Rank Sector Weight
1 Healthcare 97.55%
2 Financials 2.45%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
LXEO icon
26
Lexeo Therapeutics
LXEO
$404M
$4.32M 0.85%
928,593
– –
ALEC icon
27
Alector
ALEC
$257M
$4.22M 0.83%
2,101,068
– –
LONA
28
LeonaBio Inc
LONA
$72.8M
$3.62M 0.71%
393,701
– –
CRVS icon
29
Corvus Pharmaceuticals
CRVS
$1.19B
$3.46M 0.68%
231,585
– –
JATT
30
JATT II Acquisition Corp
JATT
$101M
$1.82M 0.36%
+160,000
New +$1.7M
CNTA
31
DELISTED
Centessa Pharmaceuticals
CNTA
– –
-489,849
Closed -$19.5M
KALV
32
DELISTED
KalVista Pharmaceuticals
KALV
– –
-897,681
Closed -$18.1M
MAZE
33
Maze Therapeutics
MAZE
$1.64B
– –
-200,000
Closed -$5.97M
1
2

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Spruce Street Capital's Q2 2026 Portfolio in Review

As of Q2 2026, Spruce Street Capital held 33 positions worth $510M, up 23% from $416M the previous quarter. Its ten largest holdings account for 70% of the portfolio.

Spruce Street Capital's Q2 2026 filing shows 5 new, 8 increased, 1 reduced and 3 closed positions. Its largest new stake was InflaRx: 5,352,198 shares worth $12M. The largest sale was Centessa Pharmaceuticals, an estimated $19.5M.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 99% a quarter earlier, followed by Financials.

  • Spruce Street Capital's largest Q2 2026 buy was InflaRx: 5,352,198 shares worth $12M.
  • Spruce Street Capital added most to Alkermes in Q2 2026, an estimated $8.82M increase.
  • Spruce Street Capital's biggest Q2 2026 reduction was Dianthus Therapeutics, cutting an estimated $1.61M.
  • Spruce Street Capital fully exited Centessa Pharmaceuticals in Q2 2026, selling an estimated $19.5M.
  • Spruce Street Capital's ten largest holdings make up 70% of its $510M portfolio in Q2 2026.
  • Spruce Street Capital opened 5 new positions and closed 3 in Q2 2026.
  • Spruce Street Capital's portfolio value rose 23% quarter-over-quarter to $510M.

Based on Spruce Street Capital's 13F filing for Q2 2026, filed 13 Aug 2026.