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SFM

Sphera Funds Management Portfolio holdings

AUM $630M
1-Year Est. Return 108.65%
This Fund
S&P 500
This Quarter Est. Return
-0.94%
1 Year Est. Return
+108.65%
3 Year Est. Return
+217.64%
5 Year Est. Return
+342.91%
10 Year Est. Return
+2,254.45%
AUM
$553M
AUM Growth
-$75.2M
Cap. Flow
-$19.5M
Cap. Flow %
-3.53%
Top 10 Hldgs %
31.54%
Holding
133
New
18
Increased
30
Reduced
36
Closed
26

Top Buys

Rank Stock Value
1
GOOG icon
Alphabet (Google) Class C
GOOG
+$7.68M
2
ANNX icon
Annexon
ANNX
+$7.65M
3
ORA icon
Ormat Technologies
ORA
+$6.1M
4
SNDX icon
Syndax Pharmaceuticals
SNDX
+$5.93M
5
SEDG icon
SolarEdge
SEDG
+$5.77M

Top Sells

Rank Stock Value
1
AAPL icon
Apple
AAPL
+$14.2M
2
TEVA icon
Teva Pharmaceuticals
TEVA
+$10.2M
3
AMZN icon
Amazon
AMZN
+$8.8M
4
S icon
SentinelOne
S
+$6.62M
5
NICE icon
Nice
NICE
+$6.39M

Sector Composition

Rank Sector Weight
1 Healthcare 73.33%
2 Technology 15.86%
3 Communication Services 3.88%
4 Consumer Discretionary 2.48%
5 Utilities 0.97%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
IONS icon
76
Ionis Pharmaceuticals
IONS
$8.6B
$2.23M 0.4%
63,821
– –
VTYX
77
DELISTED
Ventyx Biosciences
VTYX
$2.22M 0.4%
1,012,749
– –
ORIC icon
78
Oric Pharmaceuticals
ORIC
$1.15B
$2.2M 0.4%
273,213
+144,817
+113% +$1.33M
CMMB
79
Chemomab Therapeutics
CMMB
$11.4M
$2.2M 0.4%
303,644
– –
XENE icon
80
Xenon Pharmaceuticals
XENE
$6.06B
$2.04M 0.37%
+52,097
New +$2.15M
PMN icon
81
ProMIS Neurosciences
PMN
$123M
$1.83M 0.33%
77,172
– –
UBER icon
82
Uber
UBER
$143B
$1.81M 0.33%
+30,000
New +$2.14M
LRMR icon
83
Larimar Therapeutics
LRMR
$397M
$1.76M 0.32%
455,604
+41,126
+10% +$271K
ZURA icon
84
Zura Bio
ZURA
$516M
$1.73M 0.31%
690,718
-48,000
-6% -$171K
SHLT
85
DELISTED
SHL Telemedicine Ltd American Depositary Shares
SHLT
$1.68M 0.3%
632,456
– –
JSPR icon
86
PUT
Jasper Therapeutics
JSPR
$21M
$1.66M 0.3%
+77,500
New +$1.61M
CATX icon
87
Perspective Therapeutics
CATX
$332M
$1.47M 0.27%
460,247
-129,048
-22% -$1.05M
JSPR icon
88
CALL
Jasper Therapeutics
JSPR
$21M
$1.31M 0.24%
61,100
– –
ATXS
89
DELISTED
Astria Therapeutics
ATXS
$1.25M 0.23%
139,800
+3,218
+2% +$34.2K
BMY icon
90
Bristol-Myers Squibb
BMY
$133B
$1.13M 0.2%
+20,000
New +$1.12M
MRSN
91
DELISTED
Mersana Therapeutics
MRSN
$987K 0.18%
+27,611
New +$1.43M
ALMS
92
Alumis Inc
ALMS
$3.6B
$983K 0.18%
125,000
– –
HOWL icon
93
Werewolf Therapeutics
HOWL
$17.2M
$928K 0.17%
626,810
– –
APRE icon
94
Aprea Therapeutics
APRE
$7.68M
$888K 0.16%
270,000
– –
PERI icon
95
Perion Network
PERI
$375M
$869K 0.16%
102,612
-131,997
-56% -$1.11M
OKUR
96
OnKure Therapeutics
OKUR
$154M
$751K 0.14%
+87,354
New +$1.32M
KZR
97
DELISTED
Kezar Life Sciences
KZR
$729K 0.13%
108,473
+87,956
+429% +$655K
FATE icon
98
Fate Therapeutics
FATE
$286M
$655K 0.12%
+397,177
New +$1M
ALEC icon
99
Alector
ALEC
$168M
$614K 0.11%
324,639
-295,361
-48% -$1.11M
ELEV
100
DELISTED
Elevation Oncology
ELEV
$573K 0.1%
1,018,562
-61,200
-6% -$36.1K
2 3
4
5 6

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FCFC
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PWW
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SWP
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EIM
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Sphera Funds Management's Q4 2024 Portfolio in Review

As of Q4 2024, Sphera Funds Management held 133 positions worth $553M, down 12% from $628M the previous quarter. Its ten largest holdings account for 32% of the portfolio.

Sphera Funds Management withdrew a net $19.5M in Q4 2024, closing 26 positions and reducing 36 holdings. Its most notable exit was Apple, an estimated $14.2M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 73% of assets, up from 70% a quarter earlier, followed by Technology and Communication Services.

Against the trend, Sphera Funds Management opened a new position in Alphabet (Google) Class C worth $8.28M.

  • Sphera Funds Management's largest Q4 2024 buy was Alphabet (Google) Class C: 43,500 shares worth $8.28M.
  • Sphera Funds Management added most to Syndax Pharmaceuticals in Q4 2024, an estimated $5.93M increase.
  • Sphera Funds Management's biggest Q4 2024 reduction was Teva Pharmaceuticals, cutting an estimated $10.2M.
  • Sphera Funds Management fully exited Apple in Q4 2024, selling an estimated $14.2M.
  • Sphera Funds Management's ten largest holdings make up 32% of its $553M portfolio in Q4 2024.
  • Sphera Funds Management opened 18 new positions and closed 26 in Q4 2024.
  • Sphera Funds Management's portfolio value fell 12% quarter-over-quarter to $553M.

Based on Sphera Funds Management's 13F filing for Q4 2024, filed 14 Feb 2025.