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Rock Springs Capital Management Portfolio holdings

AUM $2.05B
1-Year Est. Return 161.37%
This Fund
S&P 500
This Quarter Est. Return
+46.69%
1 Year Est. Return
+161.37%
3 Year Est. Return
+342.48%
5 Year Est. Return
+531.16%
10 Year Est. Return
+6,258.71%
AUM
$2.05B
AUM Growth
+$352M
Cap. Flow
-$16.5M
Cap. Flow %
-0.81%
Top 10 Hldgs %
43.96%
Holding
116
New
16
Increased
40
Reduced
31
Closed
12

Top Buys

Rank Stock Value
1
TVTX icon
Travere Therapeutics
TVTX
+$31.1M
2
AVLN
Avalyn Pharma
AVLN
+$19.1M
3
PBLS
Parabilis Medicines Inc
PBLS
+$16M
4
COAG
Hemab Therapeutics
COAG
+$15.9M
5
CYTK icon
Cytokinetics
CYTK
+$10.2M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$37.7M
2
ACLX
Arcellx
ACLX
+$19.5M
3
ELVN icon
Enliven Therapeutics
ELVN
+$15.4M
4
RVMD icon
Revolution Medicines
RVMD
+$15.2M
5
CNTA
Centessa Pharmaceuticals
CNTA
+$14M

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
GKOS icon
101
Glaukos
GKOS
$10.6B
$664K 0.03%
+4,750
New +$601K
JSPR icon
102
Jasper Therapeutics
JSPR
$23.3M
$463K 0.02%
1,100,726
– –
BCRX icon
103
BioCryst Pharmaceuticals
BCRX
$2.51B
$221K 0.01%
22,124
+9,524
+76% +$86.1K
MLTX icon
104
MoonLake Immunotherapeutics
MLTX
$1.28B
$208K 0.01%
10,696
-51,004
-83% -$925K
ACHC icon
105
Acadia Healthcare
ACHC
$2.66B
– –
-75,500
Closed -$1.77M
ACLX
106
DELISTED
Arcellx
ACLX
– –
-169,859
Closed -$19.5M
APLS
107
DELISTED
Apellis Pharmaceuticals
APLS
– –
-162,750
Closed -$6.55M
CNTA
108
DELISTED
Centessa Pharmaceuticals
CNTA
– –
-351,828
Closed -$14M
EW icon
109
Edwards Lifesciences
EW
$52B
– –
-28,900
Closed -$2.31M
FOLD
110
DELISTED
Amicus Therapeutics
FOLD
– –
-21,062
Closed -$305K
GOSS icon
111
Gossamer Bio
GOSS
$83.2M
– –
-1,609,492
Closed -$529K
JAZZ icon
112
Jazz Pharmaceuticals
JAZZ
$15.9B
– –
-5,750
Closed -$1.09M
REGN icon
113
Regeneron Pharmaceuticals
REGN
$81.8B
– –
-10,100
Closed -$7.8M
SLNO
114
DELISTED
Soleno Therapeutics
SLNO
– –
-257,253
Closed -$8.61M
TERN
115
DELISTED
Terns Pharmaceuticals
TERN
– –
-113,748
Closed -$6M
XBI icon
116
State Street SPDR S&P Biotech ETF
XBI
$11.3B
– –
-30,000
Closed -$3.83M
1 2 3 4
5

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Rock Springs Capital Management's Q2 2026 Portfolio in Review

As of Q2 2026, Rock Springs Capital Management held 116 positions worth $2.05B, up 21% from $1.7B the previous quarter. Its ten largest holdings account for 44% of the portfolio.

Rock Springs Capital Management's Q2 2026 filing shows 16 new, 40 increased, 31 reduced and 12 closed positions. Its largest new stake was Avalyn Pharma: 662,918 shares worth $21.8M. The largest sale was argenx, an estimated $37.7M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier.

  • Rock Springs Capital Management's largest Q2 2026 buy was Avalyn Pharma: 662,918 shares worth $21.8M.
  • Rock Springs Capital Management added most to Travere Therapeutics in Q2 2026, an estimated $31.1M increase.
  • Rock Springs Capital Management's biggest Q2 2026 reduction was argenx, cutting an estimated $37.7M.
  • Rock Springs Capital Management fully exited Arcellx in Q2 2026, selling an estimated $19.5M.
  • Rock Springs Capital Management's ten largest holdings make up 44% of its $2.05B portfolio in Q2 2026.
  • Rock Springs Capital Management opened 16 new positions and closed 12 in Q2 2026.
  • Rock Springs Capital Management's portfolio value rose 21% quarter-over-quarter to $2.05B.

Based on Rock Springs Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.