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Rock Springs Capital Management Portfolio holdings

AUM $2.05B Turnover 24.14%
1-Year Est. Return 161.37%
This Fund
S&P 500
This Quarter Est. Return
+46.69%
1 Year Est. Return
+161.37%
3 Year Est. Return
+342.48%
5 Year Est. Return
+531.16%
10 Year Est. Return
+6,258.71%
AUM
$2.05B
AUM Growth
+$352M
Cap. Flow
-$16.5M
Cap. Flow %
-0.81%
Top 10 Hldgs %
43.96%
Holding
116
New
16
Increased
40
Reduced
31
Closed
12
Avg Time Held
2.7 years
Top 10 Avg Time Held
1 year
Top 20 Avg Time Held
1.8 years

Top Buys

Rank Stock Value
1
TVTX icon
Travere Therapeutics
TVTX
+$31.1M
2
AVLN icon
Avalyn Pharma
AVLN
+$19.1M
3
PBLS
Parabilis Medicines Inc
PBLS
+$16M
4
COAG icon
Hemab Therapeutics
COAG
+$15.9M
5
CYTK icon
Cytokinetics
CYTK
+$10.2M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$37.7M
2
ACLX icon
Arcellx
ACLX
+$19.5M
3
ELVN icon
Enliven Therapeutics
ELVN
+$15.4M
4
RVMD icon
Revolution Medicines
RVMD
+$15.2M
5
CNTA
Centessa Pharmaceuticals
CNTA
+$14M

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow Held Since
EYPT icon
76
EyePoint Inc
EYPT
$271M
$3.84M 0.19%
268,519
+9,780
+4% +$131K
2025 Q3
3 quarters
OCUL icon
77
Ocular Therapeutix
OCUL
$1.62B
$3.77M 0.18%
383,716
– –
2025 Q3
3 quarters
SYRE icon
78
Spyre Therapeutics
SYRE
$7.49B
$3.75M 0.18%
+42,254
New +$3.08M
2026 Q2
0 quarters
TLPH icon
79
Talphera
TLPH
$55.5M
$3.7M 0.18%
3,589,186
– –
2020 Q3
23 quarters
ROIV icon
80
Roivant Sciences
ROIV
$24.6B
$3.57M 0.17%
101,000
+4,000
+4% +$118K
2025 Q4
2 quarters
PCVX icon
81
Vaxcyte
PCVX
$10.3B
$3.5M 0.17%
60,250
– –
2025 Q2
4 quarters
NGNE icon
82
Neurogene
NGNE
$479M
$3.36M 0.16%
106,750
+2,411
+2% +$66.4K
2024 Q4
6 quarters
IPSC icon
83
Century Therapeutics
IPSC
$272M
$3.2M 0.16%
1,304,347
– –
2026 Q1
1 quarter
ATEC icon
84
Alphatec Holdings
ATEC
$1.69B
$3.11M 0.15%
360,000
+10,000
+3% +$91.1K
2024 Q4
6 quarters
NVO icon
85
Novo Nordisk
NVO
$173B
$3.04M 0.15%
63,500
-26,500
-29% -$1.14M
2026 Q1
1 quarter
OLMA icon
86
Olema Pharmaceuticals
OLMA
$601M
$2.94M 0.14%
235,178
+64,800
+38% +$868K
2025 Q4
2 quarters
NGEN icon
87
NervGen Pharma
NGEN
$174M
$2.49M 0.12%
+1,208,231
New +$3.75M
2026 Q2
0 quarters
MDT icon
88
Medtronic
MDT
$122B
$2.42M 0.12%
+30,900
New +$2.49M
2026 Q2
0 quarters
TEVA icon
89
Teva Pharmaceutical Industries Limited
TEVA
$47.9B
$2M 0.1%
59,000
+13,500
+30% +$450K
2025 Q4
2 quarters
DNTH icon
90
Dianthus Therapeutics
DNTH
$4.17B
$1.98M 0.1%
20,326
-6,431
-24% -$562K
2026 Q1
1 quarter
SGMT icon
91
Sagimet Biosciences
SGMT
$579M
$1.93M 0.09%
+250,000
New +$1.7M
2026 Q2
0 quarters
CAPR icon
92
Capricor Therapeutics
CAPR
$423M
$1.79M 0.09%
+74,448
New +$2.26M
2026 Q2
0 quarters
LENZ icon
93
LENZ Therapeutics
LENZ
$112M
$1.46M 0.07%
257,460
– –
2024 Q4
6 quarters
ALT icon
94
Altimmune
ALT
$459M
$1.43M 0.07%
+471,465
New +$1.41M
2026 Q2
0 quarters
KLRA icon
95
Kailera Therapeutics
KLRA
$1.52B
$1.43M 0.07%
+65,000
New +$1.43M
2026 Q2
0 quarters
SGRY icon
96
Surgery Partners
SGRY
$1.93B
$1.41M 0.07%
84,000
-124,000
-60% -$1.74M
2025 Q4
2 quarters
AXSM icon
97
Axsome Therapeutics
AXSM
$8.47B
$1.35M 0.07%
+5,500
New +$1.19M
2026 Q2
0 quarters
ORKA icon
98
Oruka Therapeutics
ORKA
$4.89B
$1.15M 0.06%
12,051
+7,928
+192% +$528K
2026 Q1
1 quarter
VKTX icon
99
Viking Therapeutics
VKTX
$3.48B
$995K 0.05%
25,500
-70,500
-73% -$2.28M
2026 Q1
1 quarter
LEGN icon
100
Legend Biotech
LEGN
$3.85B
$967K 0.05%
33,500
-7,000
-17% -$189K
2025 Q4
2 quarters
1 2 3
4
5

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Rock Springs Capital Management's Q2 2026 Portfolio in Review

As of Q2 2026, Rock Springs Capital Management held 116 positions worth $2.05B, up 21% from $1.7B the previous quarter. Its ten largest holdings account for 44% of the portfolio.

Rock Springs Capital Management's Q2 2026 filing shows 16 new, 40 increased, 31 reduced and 12 closed positions. Its largest new stake was Avalyn Pharma: 662,918 shares worth $21.8M. The largest sale was argenx, an estimated $37.7M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier.

  • Rock Springs Capital Management's largest Q2 2026 buy was Avalyn Pharma: 662,918 shares worth $21.8M.
  • Rock Springs Capital Management added most to Travere Therapeutics in Q2 2026, an estimated $31.1M increase.
  • Rock Springs Capital Management's biggest Q2 2026 reduction was argenx, cutting an estimated $37.7M.
  • Rock Springs Capital Management fully exited Arcellx in Q2 2026, selling an estimated $19.5M.
  • Rock Springs Capital Management's ten largest holdings make up 44% of its $2.05B portfolio in Q2 2026.
  • Rock Springs Capital Management opened 16 new positions and closed 12 in Q2 2026.
  • Rock Springs Capital Management's portfolio value rose 21% quarter-over-quarter to $2.05B.

Based on Rock Springs Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.