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Prosight Management Portfolio holdings

AUM $580M
1-Year Est. Return 29.81%
This Fund
S&P 500
This Quarter Est. Return
+4.78%
1 Year Est. Return
+29.81%
3 Year Est. Return
+39.55%
5 Year Est. Return
-6.93%
10 Year Est. Return
–
AUM
$484M
AUM Growth
+$55.1M
Cap. Flow
+$73.1M
Cap. Flow %
15.11%
Top 10 Hldgs %
57.22%
Holding
53
New
11
Increased
11
Reduced
16
Closed
15

Top Buys

Rank Stock Value
1
PRCT icon
Procept Biorobotics
PRCT
+$43.2M
2
JANX icon
Janux Therapeutics
JANX
+$35.9M
3
NKTR icon
Nektar Therapeutics
NKTR
+$31M
4
VEEV icon
Veeva Systems
VEEV
+$23.9M
5
PHR icon
Phreesia
PHR
+$20.2M

Top Sells

Rank Stock Value
1
ISRG icon
Intuitive Surgical
ISRG
+$21.8M
2
BBIO icon
BridgeBio Pharma
BBIO
+$15.4M
3
ROIV icon
Roivant Sciences
ROIV
+$14M
4
DXCM icon
DexCom
DXCM
+$13.1M
5
IMVT icon
Immunovant
IMVT
+$10.1M

Sector Composition

Rank Sector Weight
1 Healthcare 99.58%
2 Industrials 0.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TWST icon
51
Twist Bioscience
TWST
$8.87B
– –
-75,000
Closed -$2.11M
VRTX icon
52
Vertex Pharmaceuticals
VRTX
$137B
– –
-20,500
Closed -$8.03M
ACTU
53
Actuate Therapeutics
ACTU
$39.9M
– –
-885
Closed -$5.92K
1 2
3

Similar funds

SC
Stempoint Capital New York $581M AUM 373.68% 1-Year Est. Return
CCWM
Correct Capital Wealth Management Clayton, Missouri $580M AUM 16.45% 1-Year Est. Return
CMA
Cedar Mountain Advisors Lake Oswego, Oregon $581M AUM 18.16% 1-Year Est. Return
RIS
Retirement Income Solutions Ann Arbor, Michigan $581M AUM 19.42% 1-Year Est. Return
MFS
McNamara Financial Services Marshfield, Massachusetts $580M AUM 17.89% 1-Year Est. Return
GFI
Global Frontier Investments Charleston, South Carolina $581M AUM 8.55% 1-Year Est. Return
PWM
Praetorian Wealth Management Carmel, California $580M AUM 19.43% 1-Year Est. Return
CA
COFG Advisors Oak Brook, Illinois $579M AUM

Prosight Management's Q4 2025 Portfolio in Review

As of Q4 2025, Prosight Management held 53 positions worth $484M, up 13% from $429M the previous quarter. Its ten largest holdings account for 57% of the portfolio.

Prosight Management deployed $73.1M of net new capital in Q4 2025, opening 11 new positions and adding to 11 existing holdings. Its largest new stake was Nektar Therapeutics: 554,633 shares worth $23.4M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 97% a quarter earlier, followed by Industrials.

On the sell side, the largest reduction was BridgeBio Pharma, an estimated $15.4M trimmed.

  • Prosight Management's largest Q4 2025 buy was Nektar Therapeutics: 554,633 shares worth $23.4M.
  • Prosight Management added most to Procept Biorobotics in Q4 2025, an estimated $43.2M increase.
  • Prosight Management's biggest Q4 2025 reduction was BridgeBio Pharma, cutting an estimated $15.4M.
  • Prosight Management fully exited Intuitive Surgical in Q4 2025, selling an estimated $21.8M.
  • Prosight Management's ten largest holdings make up 57% of its $484M portfolio in Q4 2025.
  • Prosight Management opened 11 new positions and closed 15 in Q4 2025.
  • Prosight Management's portfolio value rose 13% quarter-over-quarter to $484M.

Based on Prosight Management's 13F filing for Q4 2025, filed 13 Feb 2026.