Opaleye Management’s Neurogene NGNE Stock Holding History

Quarter	Market Value	Status	Shares	Shares Change %	Trade Value	Portfolio Weight	Portfolio Position
2022 Q4	–	Sell	-575,000	Closed	-$368K	–	45
2022 Q3	$368K	Sell	575,000 -35,000	-6%	-$22.4K	0.15%	38
2022 Q2	$628K	Sell	610,000 -180,000	-23%	-$185K	0.28%	38
2022 Q1	$1.49M	Sell	790,000 -257,300	-25%	-$484K	0.46%	35
2021 Q4	$5.05M	Hold	1,047,300	–	–	1.07%	29
2021 Q3	$7.57M	Sell	1,047,300 -108,900	-9%	-$787K	1.41%	23
2021 Q2	$10.7M	Sell	1,156,200 -68,800	-6%	-$635K	1.77%	17
2021 Q1	$15.1M	Sell	1,225,000 -161,300	-12%	-$1.99M	2.22%	13
2020 Q4	$19.5M	Hold	1,386,300	–	–	2.55%	13
2020 Q3	$16.6M	Sell	1,386,300 -13,700	-1%	-$164K	3.25%	7
2020 Q2	$23.2M	Hold	1,400,000	–	–	4.69%	3
2020 Q1	$15.9M	Buy	1,400,000 +18,700	+1%	+$213K	4.22%	5
2019 Q4	$17M	Buy	1,381,300 +386,300	+39%	+$4.76M	3.34%	11
2019 Q3	$2.84M	Buy	+995,000	New	+$2.84M	1.03%	34
2017 Q2	–	Sell	-85,000	Closed	-$1.42M	–	46
2017 Q1	$1.42M	Sell	85,000 -225,000	-73%	-$3.75M	0.71%	34
2016 Q4	$5.12M	Hold	310,000	–	–	3.02%	10
2016 Q3	$4.14M	Buy	310,000 +15,000	+5%	+$200K	2.17%	18
2016 Q2	$1.95M	Buy	+295,000	New	+$1.95M	1.3%	30