Opaleye Management’s Agios Pharmaceuticals AGIO Stock Holding History

Quarter	Market Value	Status	Shares	Shares Change %	Trade Value	Portfolio Weight	Portfolio Position
2018 Q4	–	Sell	-130,000	Closed	-$10M	–	48
2018 Q3	$10M	Hold	130,000	–	–	2.55%	10
2018 Q2	$10.9M	Hold	130,000	–	–	2.83%	10
2018 Q1	$10.6M	Hold	130,000	–	–	3.04%	8
2017 Q4	$7.43M	Hold	130,000	–	–	2.38%	13
2017 Q3	$8.68M	Hold	130,000	–	–	3.07%	10
2017 Q2	$6.69M	Hold	130,000	–	–	2.79%	13
2017 Q1	$7.59M	Hold	130,000	–	–	3.78%	6
2016 Q4	$5.43M	Hold	130,000	–	–	3.2%	7
2016 Q3	$6.87M	Buy	130,000 +45,000	+53%	+$2.38M	3.59%	5
2016 Q2	$3.56M	Sell	85,000 -20,000	-19%	-$838K	2.38%	14
2016 Q1	$4.26M	Buy	+105,000	New	+$4.26M	2.66%	14
2015 Q2	–	Sell	-90,000	Closed	-$8.49M	–	47
2015 Q1	$8.49M	Sell	90,000 -23,500	-21%	-$2.22M	3.94%	7
2014 Q4	$12.7M	Hold	113,500	–	–	6.43%	2
2014 Q3	$6.96M	Sell	113,500 -1,500	-1%	-$92K	5.43%	5
2014 Q2	$5.27M	Buy	+115,000	New	+$5.27M	4.54%	10