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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
-6.84%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$23.1B
AUM Growth
-$3.48B
Cap. Flow
-$129M
Cap. Flow %
-0.56%
Top 10 Hldgs %
80.48%
Holding
138
New
11
Increased
23
Reduced
15
Closed
12

Top Buys

Rank Stock Value
1
TLIS
Talis Biomedical Corporation Common Stock
TLIS
+$126M
2
IMCR icon
Immunocore
IMCR
+$112M
3
GBT
Global Blood Therapeutics, Inc.
GBT
+$106M
4
TIL icon
Instil Bio
TIL
+$99.9M
5
DSGN icon
Design Therapeutics
DSGN
+$48.5M

Top Sells

Rank Stock Value
1
ALXN
Alexion Pharmaceuticals
ALXN
+$737M
2
KRRO icon
Korro Bio
KRRO
+$31.1M
3
ADPT icon
Adaptive Biotechnologies
ADPT
+$22.5M
4
GWPH
GW Pharmaceuticals Plc American Depositary Shares
GWPH
+$13M
5
FPRX
Five Prime Therapeutics, Inc.
FPRX
+$11.4M

Sector Composition

Rank Sector Weight
1 Healthcare 99.81%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AKRO
101
DELISTED
Akero Therapeutics
AKRO
$3.43M 0.01%
118,378
– –
LEGN icon
102
Legend Biotech
LEGN
$4.24B
$3.35M 0.01%
115,626
– –
LOGC
103
DELISTED
LogicBio Therapeutics, Inc. Common Stock
LOGC
$3.29M 0.01%
451,478
– –
TARA icon
104
Protara Therapeutics
TARA
$228M
$3.14M 0.01%
199,671
– –
XLRN
105
DELISTED
Acceleron Pharma
XLRN
$3.04M 0.01%
22,430
– –
CNST
106
DELISTED
Constellation Pharmaceuticals, Inc.
CNST
$2.68M 0.01%
114,735
– –
ACGN
107
DELISTED
Aceragen Inc
ACGN
$2.66M 0.01%
120,543
-150,833
-56% -$11.3M
AUTL
108
Autolus Therapeutics
AUTL
$641M
$2.65M 0.01%
461,726
-320,457
-41% -$2.37M
CHMA
109
DELISTED
Chiasma, Inc. Common Stock
CHMA
$2.32M 0.01%
742,133
– –
VKTX icon
110
Viking Therapeutics
VKTX
$3.95B
$2.3M 0.01%
363,980
– –
INZY
111
DELISTED
Inozyme Pharma
INZY
$2.12M 0.01%
106,999
– –
MTEM
112
DELISTED
Molecular Templates, Inc.
MTEM
$1.69M 0.01%
8,922
– –
AFMD
113
DELISTED
Affimed
AFMD
$1.3M 0.01%
16,461
– –
OYST
114
DELISTED
Oyster Point Pharma, Inc. Common Stock
OYST
$1.12M ﹤0.01%
61,424
– –
CYPH
115
Cypherpunk Technologies Inc
CYPH
$153M
$1.06M ﹤0.01%
55,971
– –
BLCM
116
DELISTED
Bellicum Pharmaceuticals, Inc.
BLCM
$937K ﹤0.01%
249,123
– –
LKFT
117
Lakefront Biotherapeutics American Depositary Shares
LKFT
$1.89B
$862K ﹤0.01%
11,180
– –
KZR
118
DELISTED
Kezar Life Sciences
KZR
$832K ﹤0.01%
13,968
– –
ADMS
119
DELISTED
Adamas Pharmaceuticals
ADMS
$710K ﹤0.01%
147,996
– –
GLMD icon
120
Galmed Pharmaceuticals
GLMD
$4.48M
$634K ﹤0.01%
128
– –
IFRX icon
121
InflaRx
IFRX
$309M
$538K ﹤0.01%
138,040
-718,188
-84% -$3.68M
KRRO icon
122
Korro Bio
KRRO
$194M
$528K ﹤0.01%
1,111
-16,019
-94% -$31.1M
GNFT
123
DELISTED
Genfit
GNFT
$68K ﹤0.01%
14,720
– –
ADPT icon
124
Adaptive Biotechnologies
ADPT
$4.15B
– –
-379,682
Closed -$22.5M
GOSS icon
125
Gossamer Bio
GOSS
$75.6M
– –
-480,729
Closed -$4.65M
2 3 4
5
6

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Julian Baker's Q1 2021 Portfolio in Review

As of Q1 2021, Julian Baker held 138 positions worth $23.1B, down 13% from $26.5B the previous quarter. Its ten largest holdings account for 80% of the portfolio.

Julian Baker's Q1 2021 filing shows 11 new, 23 increased, 15 reduced and 12 closed positions. Its largest new stake was Talis Biomedical Corporation Common Stock: 504,989 shares worth $97.3M. The largest sale was Alexion Pharmaceuticals, an estimated $737M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • Julian Baker's largest Q1 2021 buy was Talis Biomedical Corporation Common Stock: 504,989 shares worth $97.3M.
  • Julian Baker added most to Global Blood Therapeutics, Inc. in Q1 2021, an estimated $106M increase.
  • Julian Baker's biggest Q1 2021 reduction was Alexion Pharmaceuticals, cutting an estimated $737M.
  • Julian Baker fully exited Adaptive Biotechnologies in Q1 2021, selling an estimated $22.5M.
  • Julian Baker's ten largest holdings make up 80% of its $23.1B portfolio in Q1 2021.
  • Julian Baker opened 11 new positions and closed 12 in Q1 2021.
  • Julian Baker's portfolio value fell 13% quarter-over-quarter to $23.1B.

Based on Baker Bros. Advisors's 13F filing for Q1 2021, filed 17 May 2021.