We are live on ! Find out more
JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+11.22%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$10.3B
AUM Growth
+$1.27B
Cap. Flow
+$755M
Cap. Flow %
7.32%
Top 10 Hldgs %
81.62%
Holding
100
New
12
Increased
23
Reduced
8
Closed
11

Top Buys

Rank Stock Value
1
SMMT icon
Summit Therapeutics
SMMT
+$212M
2
INSM icon
Insmed
INSM
+$178M
3
ALKS icon
Alkermes
ALKS
+$57.4M
4
RVMD icon
Revolution Medicines
RVMD
+$54.9M
5
GPCR icon
Structure Therapeutics
GPCR
+$47.2M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$23.2M
2
CRSP icon
CRISPR Therapeutics
CRSP
+$22.3M
3
CNTA
Centessa Pharmaceuticals
CNTA
+$17.6M
4
TSVT
2seventy bio
TSVT
+$12.3M
5
BCAX
Bicara Therapeutics
BCAX
+$10.9M

Sector Composition

Rank Sector Weight
1 Healthcare 100%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TECX
76
Tectonic Therapeutic
TECX
$736M
$1.99M 0.02%
100,000
– –
CADL icon
77
Candel Therapeutics
CADL
$1B
$1.8M 0.02%
355,112
-2,082,077
-85% -$10.7M
TARA icon
78
Protara Therapeutics
TARA
$228M
$1.63M 0.02%
536,832
– –
VTVT icon
79
vTv Therapeutics
VTVT
$132M
$1.46M 0.01%
97,314
– –
RCKT icon
80
Rocket Pharmaceuticals
RCKT
$385M
$1.35M 0.01%
552,079
-545,000
-50% -$2.76M
CTNM
81
Contineum Therapeutics
CTNM
$647M
$1.24M 0.01%
312,500
– –
HOOK
82
DELISTED
HOOKIPA Pharma
HOOK
$1.02M 0.01%
812,814
– –
NMRA icon
83
Neumora Therapeutics
NMRA
$306M
$759K 0.01%
1,034,600
– –
GBIO
84
DELISTED
Generation Bio
GBIO
$623K 0.01%
194,495
– –
ALGS icon
85
Aligos Therapeutics
ALGS
$41.7M
$599K 0.01%
83,055
– –
TYRA icon
86
Tyra Biosciences
TYRA
$1.55B
$102K ﹤0.01%
10,607
– –
ACRV icon
87
Acrivon Therapeutics
ACRV
$94.7M
$27.1K ﹤0.01%
22,809
– –
SRZNW
88
DELISTED
Surrozen Inc Warrant
SRZNW
$15.1K ﹤0.01%
833,333
– –
CMPX icon
89
Compass Therapeutics
CMPX
$432M
– –
-547,498
Closed -$1.04M
CNTA
90
DELISTED
Centessa Pharmaceuticals
CNTA
– –
-1,227,178
Closed -$17.6M
CRSP icon
91
CRISPR Therapeutics
CRSP
$5.75B
– –
-654,099
Closed -$22.3M
DYN icon
92
Dyne Therapeutics
DYN
$4.87B
– –
-672,096
Closed -$7.03M
IONS icon
93
Ionis Pharmaceuticals
IONS
$9.93B
– –
-357,915
Closed -$10.8M
IPSC icon
94
Century Therapeutics
IPSC
$375M
– –
-241,684
Closed -$115K
CYPH
95
Cypherpunk Technologies Inc
CYPH
$153M
– –
-404,744
Closed -$123K
PRME icon
96
Prime Medicine
PRME
$615M
– –
-1,028,466
Closed -$2.05M
RGLS
97
DELISTED
Regulus Therapeutics
RGLS
– –
-2,694,044
Closed -$4.71M
TSVT
98
DELISTED
2seventy bio
TSVT
– –
-2,497,526
Closed -$12.3M
BCAX
99
Bicara Therapeutics
BCAX
$1.58B
– –
-833,333
Closed -$10.9M
OPT
100
DELISTED
Opthea Limited American Depositary Shares
OPT
$0 ﹤0.01%
2,087,320
– –
1 2 3
4

Similar funds

ASRS
Arizona State Retirement System Phoenix, Arizona $19.9B AUM 44.71% 1-Year Est. Return
FWIA
Fort Washington Investment Advisors Cincinnati, Ohio $19.9B AUM 22.19% 1-Year Est. Return
CWP
Capital Wealth Planning Naples, Florida $20B AUM 25.34% 1-Year Est. Return
SFA
Sequoia Financial Advisors Akron, Ohio $20.1B AUM 24.77% 1-Year Est. Return
MGP
M&G plc London, United Kingdom $20.1B AUM 16.62% 1-Year Est. Return
JAM
Jupiter Asset Management London, United Kingdom $20.2B AUM 29.18% 1-Year Est. Return
Verition Fund Management
Verition Fund Management Greenwich, Connecticut $19.7B AUM 39.39% 1-Year Est. Return
Select Equity Group
Select Equity Group New York $20.2B AUM 17.52% 1-Year Est. Return

Julian Baker's Q2 2025 Portfolio in Review

As of Q2 2025, Julian Baker held 100 positions worth $10.3B, up 14% from $9.04B the previous quarter. Its ten largest holdings account for 82% of the portfolio.

Julian Baker deployed $755M of net new capital in Q2 2025, opening 12 new positions and adding to 23 existing holdings. Its largest new stake was Viridian Therapeutics: 1,744,406 shares worth $24.4M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 99% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was argenx, an estimated $23.2M trimmed.

  • Julian Baker's largest Q2 2025 buy was Viridian Therapeutics: 1,744,406 shares worth $24.4M.
  • Julian Baker added most to Summit Therapeutics in Q2 2025, an estimated $212M increase.
  • Julian Baker's biggest Q2 2025 reduction was argenx, cutting an estimated $23.2M.
  • Julian Baker fully exited CRISPR Therapeutics in Q2 2025, selling an estimated $22.3M.
  • Julian Baker's ten largest holdings make up 82% of its $10.3B portfolio in Q2 2025.
  • Julian Baker opened 12 new positions and closed 11 in Q2 2025.
  • Julian Baker's portfolio value rose 14% quarter-over-quarter to $10.3B.

Based on Baker Bros. Advisors's 13F filing for Q2 2025, filed 14 Aug 2025.