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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
-1.31%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$15.3B
AUM Growth
-$2.36B
Cap. Flow
-$405M
Cap. Flow %
-2.65%
Top 10 Hldgs %
84.69%
Holding
128
New
12
Increased
7
Reduced
17
Closed
13

Top Buys

Rank Stock Value
1
RYTM icon
Rhythm Pharmaceuticals
RYTM
+$36M
2
AKRO
Akero Therapeutics
AKRO
+$34.4M
3
VERU icon
Veru
VERU
+$23.2M
4
CINC
CinCor Pharma, Inc. Common Stock
CINC
+$22.8M
5
IDYA icon
IDEAYA Biosciences
IDYA
+$21.7M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$311M
2
INSM icon
Insmed
INSM
+$51.2M
3
LEGN icon
Legend Biotech
LEGN
+$47.1M
4
KRYS icon
Krystal Biotech
KRYS
+$27.9M
5
PACB icon
Pacific Biosciences
PACB
+$24.8M

Sector Composition

Rank Sector Weight
1 Healthcare 99.7%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
KRON
76
DELISTED
Kronos Bio
KRON
$5.16M 0.03%
+1,539,616
New +$6.95M
CYT
77
DELISTED
Cyteir Therapeutics, Inc. Common Stock
CYT
$5.08M 0.03%
2,643,640
– –
SRZN icon
78
Surrozen
SRZN
$282M
$5.05M 0.03%
166,667
– –
EWTX icon
79
Edgewise Therapeutics
EWTX
$4.8B
$4.92M 0.03%
500,000
– –
FATE icon
80
Fate Therapeutics
FATE
$279M
$4.83M 0.03%
+215,695
New +$6.23M
STOK icon
81
Stoke Therapeutics
STOK
$2.08B
$4.74M 0.03%
+369,327
New +$5.89M
NTRA icon
82
Natera
NTRA
$47.9B
$4.38M 0.03%
100,000
– –
RVMD icon
83
Revolution Medicines
RVMD
$44.9B
$4.38M 0.03%
222,222
– –
ALLK
84
DELISTED
Allakos
ALLK
$4.3M 0.03%
703,050
– –
EIGR
85
DELISTED
Eiger BioPharmaceuticals, Inc.
EIGR
$4.07M 0.03%
+17,995
New +$4.42M
PMVP icon
86
PMV Pharmaceuticals
PMVP
$71.1M
$3.83M 0.03%
+322,024
New +$4.65M
IPSC icon
87
Century Therapeutics
IPSC
$375M
$3.67M 0.02%
+370,587
New +$3.9M
HOOK
88
DELISTED
HOOKIPA Pharma
HOOK
$3.22M 0.02%
240,048
– –
LONA
89
LeonaBio Inc
LONA
$72.4M
$3.09M 0.02%
104,083
– –
MGNX icon
90
MacroGenics
MGNX
$261M
$3.09M 0.02%
892,579
– –
ITOS
91
DELISTED
iTeos Therapeutics
ITOS
$2.86M 0.02%
150,346
– –
ATRA icon
92
Atara Biotherapeutics
ATRA
$97.4M
$2.81M 0.02%
29,767
– –
TNGX icon
93
Tango Therapeutics
TNGX
$4.03B
$2.71M 0.02%
750,000
– –
SNDX icon
94
Syndax Pharmaceuticals
SNDX
$1.75B
$2.66M 0.02%
110,729
– –
OTIC
95
DELISTED
Otonomy, Inc.
OTIC
$2.49M 0.02%
8,443,134
+30,500
+0.4% +$26.7K
NGNE icon
96
Neurogene
NGNE
$773M
$2.45M 0.02%
191,087
– –
ALGS icon
97
Aligos Therapeutics
ALGS
$41.7M
$2.28M 0.02%
83,056
– –
ALEC icon
98
Alector
ALEC
$264M
$2.26M 0.01%
239,228
– –
SYRE icon
99
Spyre Therapeutics
SYRE
$9.39B
$1.79M 0.01%
136,404
– –
TCRR
100
DELISTED
TCR2 Therapeutics Inc. Common Stock
TCRR
$1.36M 0.01%
753,064
– –
2 3
4
5 6

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Julian Baker's Q3 2022 Portfolio in Review

As of Q3 2022, Julian Baker held 128 positions worth $15.3B, down 13% from $17.6B the previous quarter. Its ten largest holdings account for 85% of the portfolio.

Julian Baker's Q3 2022 filing shows 12 new, 7 increased, 17 reduced and 13 closed positions. Its largest new stake was Veru: 160,958 shares worth $18.5M. The largest sale was argenx, an estimated $311M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • Julian Baker's largest Q3 2022 buy was Veru: 160,958 shares worth $18.5M.
  • Julian Baker added most to Rhythm Pharmaceuticals in Q3 2022, an estimated $36M increase.
  • Julian Baker's biggest Q3 2022 reduction was argenx, cutting an estimated $311M.
  • Julian Baker fully exited Legend Biotech in Q3 2022, selling an estimated $47.1M.
  • Julian Baker's ten largest holdings make up 85% of its $15.3B portfolio in Q3 2022.
  • Julian Baker opened 12 new positions and closed 13 in Q3 2022.
  • Julian Baker's portfolio value fell 13% quarter-over-quarter to $15.3B.

Based on Baker Bros. Advisors's 13F filing for Q3 2022, filed 14 Nov 2022.