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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+3.6%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$22.8B
AUM Growth
-$295M
Cap. Flow
-$688M
Cap. Flow %
-3.02%
Top 10 Hldgs %
81.57%
Holding
135
New
6
Increased
16
Reduced
10
Closed
15

Top Buys

Rank Stock Value
1
VERV
Verve Therapeutics
VERV
+$58.8M
2
LEGN icon
Legend Biotech
LEGN
+$52.6M
3
HRTX icon
Heron Therapeutics
HRTX
+$34M
4
JBIO
Jade Biosciences
JBIO
+$32.6M
5
APLS
Apellis Pharmaceuticals
APLS
+$30.9M

Top Sells

Rank Stock Value
1
ALXN
Alexion Pharmaceuticals
ALXN
+$611M
2
NVTA
Invitae Corporation
NVTA
+$179M
3
CCXI
ChemoCentryx, Inc.
CCXI
+$33.6M
4
PTGX icon
Protagonist Therapeutics
PTGX
+$32.4M
5
ALT icon
Altimmune
ALT
+$23.1M

Sector Composition

Rank Sector Weight
1 Healthcare 99.26%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ASMB icon
76
Assembly Biosciences
ASMB
$700M
$8.18M 0.04%
175,718
+47,266
+37% +$2.34M
KRTX
77
DELISTED
Karuna Therapeutics, Inc. Common Stock
KRTX
$7.97M 0.04%
69,966
– –
MREO
78
Mereo BioPharma
MREO
$46.4M
$7.8M 0.03%
2,459,399
-4,260,549
-63% -$14.3M
SPRY icon
79
ARS Pharmaceuticals
SPRY
$547M
$7.36M 0.03%
238,095
– –
BLUE
80
DELISTED
bluebird bio
BLUE
$7.26M 0.03%
17,523
– –
RVMD icon
81
Revolution Medicines
RVMD
$44.9B
$7.05M 0.03%
222,222
– –
DNLI icon
82
Denali Therapeutics
DNLI
$3.98B
$6.96M 0.03%
88,738
– –
CHMA
83
DELISTED
Chiasma, Inc. Common Stock
CHMA
$6.72M 0.03%
1,420,740
+678,607
+91% +$2.56M
HOOK
84
DELISTED
HOOKIPA Pharma
HOOK
$6.42M 0.03%
70,048
– –
BNR
85
Burning Rock Biotech
BNR
$103M
$6.16M 0.03%
20,913
– –
REPL icon
86
Replimune Group
REPL
$1.39B
$5.9M 0.03%
153,512
– –
NGM
87
DELISTED
NGM Biopharmaceuticals, Inc. Common Stock
NGM
$5.75M 0.03%
291,801
– –
CABA icon
88
Cabaletta Bio
CABA
$531M
$5.47M 0.02%
636,363
– –
MGNX icon
89
MacroGenics
MGNX
$261M
$5.39M 0.02%
200,679
– –
ORTX
90
DELISTED
Orchard Therapeutics plc American Depositary Shares
ORTX
$5.23M 0.02%
119,200
+45,757
+62% +$2.55M
ALEC icon
91
Alector
ALEC
$264M
$4.98M 0.02%
239,228
– –
NEXI
92
DELISTED
NexImmune, Inc. Common Stock
NEXI
$4.8M 0.02%
11,765
– –
BMEA icon
93
Biomea Fusion
BMEA
$99.3M
$4.59M 0.02%
+294,117
New +$5.19M
GMDA
94
DELISTED
Gamida Cell Ltd. Ordinary Shares
GMDA
$3.91M 0.02%
610,626
-426,600
-41% -$2.94M
ITOS
95
DELISTED
iTeos Therapeutics
ITOS
$3.86M 0.02%
150,346
– –
HRMY icon
96
Harmony Biosciences
HRMY
$2.22B
$3.49M 0.02%
123,600
– –
TCDA
97
DELISTED
Tricida, Inc. Common Stock
TCDA
$3.15M 0.01%
729,300
– –
EVFM
98
DELISTED
Evofem Biosciences, Inc. Common Stock
EVFM
$3.05M 0.01%
179,807
– –
AKRO
99
DELISTED
Akero Therapeutics
AKRO
$2.94M 0.01%
118,378
– –
TCRR
100
DELISTED
TCR2 Therapeutics Inc. Common Stock
TCRR
$2.9M 0.01%
176,461
– –
2 3
4
5 6

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Julian Baker's Q2 2021 Portfolio in Review

As of Q2 2021, Julian Baker held 135 positions worth $22.8B, down 1.3% from $23.1B the previous quarter. Its ten largest holdings account for 82% of the portfolio.

Julian Baker withdrew a net $688M in Q2 2021, closing 15 positions and reducing 10 holdings. Its most notable exit was Alexion Pharmaceuticals, an estimated $611M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, down from 100% a quarter earlier, followed by Financials.

Against the trend, Julian Baker opened a new position in Verve Therapeutics worth $85.3M.

  • Julian Baker's largest Q2 2021 buy was Verve Therapeutics: 1,416,530 shares worth $85.3M.
  • Julian Baker added most to Legend Biotech in Q2 2021, an estimated $52.6M increase.
  • Julian Baker's biggest Q2 2021 reduction was Invitae Corporation, cutting an estimated $179M.
  • Julian Baker fully exited Alexion Pharmaceuticals in Q2 2021, selling an estimated $611M.
  • Julian Baker's ten largest holdings make up 82% of its $22.8B portfolio in Q2 2021.
  • Julian Baker opened 6 new positions and closed 15 in Q2 2021.
  • Julian Baker's portfolio value fell 1.3% quarter-over-quarter to $22.8B.

Based on Baker Bros. Advisors's 13F filing for Q2 2021, filed 16 Aug 2021.