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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+18.97%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$26.5B
AUM Growth
+$1.52B
Cap. Flow
-$117M
Cap. Flow %
-0.44%
Top 10 Hldgs %
84.24%
Holding
133
New
14
Increased
16
Reduced
60
Closed
7

Top Buys

Rank Stock Value
1
ABCL icon
AbCellera Biologics
ABCL
+$478M
2
NVTA
Invitae Corporation
NVTA
+$181M
3
KOD icon
Kodiak Sciences
KOD
+$170M
4
RARE icon
Ultragenyx Pharmaceutical
RARE
+$52.7M
5
OPT
Opthea Limited American Depositary Shares
OPT
+$41.8M

Top Sells

Rank Stock Value
1
ONC
BeOne Medicines Ltd
ONC
+$450M
2
MYOK
MyoKardia, Inc. Common Stock
MYOK
+$410M
3
EXAS
Exact Sciences
EXAS
+$188M
4
IMMU
Immunomedics Inc
IMMU
+$20.2M
5
AMRN
Amarin Corp
AMRN
+$19.4M

Sector Composition

Rank Sector Weight
1 Healthcare 99.87%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CRNX icon
76
Crinetics Pharmaceuticals
CRNX
$8.99B
$8.7M 0.03%
616,520
+314,200
+104% +$4.38M
VXRT
77
DELISTED
Vaxart
VXRT
$7.99M 0.03%
1,398,795
-167,326
-11% -$1.06M
CABA icon
78
Cabaletta Bio
CABA
$531M
$7.94M 0.03%
636,363
– –
HOOK
79
DELISTED
HOOKIPA Pharma
HOOK
$7.77M 0.03%
70,048
– –
SYRS
80
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
$7.49M 0.03%
69,017
– –
DNLI icon
81
Denali Therapeutics
DNLI
$3.98B
$7.43M 0.03%
88,738
-10,662
-11% -$645K
KRTX
82
DELISTED
Karuna Therapeutics, Inc. Common Stock
KRTX
$7.11M 0.03%
69,966
-7,810
-10% -$724K
AUTL
83
Autolus Therapeutics
AUTL
$641M
$6.99M 0.03%
782,183
+320,859
+70% +$3.42M
HRMY icon
84
Harmony Biosciences
HRMY
$2.22B
$6.51M 0.02%
180,000
-220,000
-55% -$8.88M
GTH
85
DELISTED
Genetron Holdings Limited ADS
GTH
$6.37M 0.02%
151,769
+118,436
+355% +$4.29M
NTLA icon
86
Intellia Therapeutics
NTLA
$1.8B
$6.05M 0.02%
111,296
-10,942
-9% -$397K
PASG icon
87
Passage Bio
PASG
$14.3M
$6.02M 0.02%
11,768
-1,285
-10% -$515K
REPL icon
88
Replimune Group
REPL
$1.39B
$5.86M 0.02%
153,512
-53,074
-26% -$2.21M
ITOS
89
DELISTED
iTeos Therapeutics
ITOS
$5.08M 0.02%
150,346
-17,216
-10% -$456K
TARA icon
90
Protara Therapeutics
TARA
$228M
$4.83M 0.02%
199,671
– –
BNR
91
Burning Rock Biotech
BNR
$103M
$4.83M 0.02%
20,913
-2,817
-12% -$756K
GOSS icon
92
Gossamer Bio
GOSS
$75.6M
$4.65M 0.02%
+480,729
New +$4.74M
MGNX icon
93
MacroGenics
MGNX
$261M
$4.59M 0.02%
+200,679
New +$4.62M
TCDA
94
DELISTED
Tricida, Inc. Common Stock
TCDA
$4.44M 0.02%
+629,300
New +$4.83M
IFRX icon
95
InflaRx
IFRX
$309M
$4.31M 0.02%
856,228
-151,331
-15% -$681K
ALEC icon
96
Alector
ALEC
$264M
$3.62M 0.01%
239,228
-26,372
-10% -$328K
LOGC
97
DELISTED
LogicBio Therapeutics, Inc. Common Stock
LOGC
$3.44M 0.01%
+451,478
New +$3.02M
TCRR
98
DELISTED
TCR2 Therapeutics Inc. Common Stock
TCRR
$3.43M 0.01%
110,888
-11,644
-10% -$294K
CNST
99
DELISTED
Constellation Pharmaceuticals, Inc.
CNST
$3.3M 0.01%
114,735
-18,598
-14% -$468K
LEGN icon
100
Legend Biotech
LEGN
$4.24B
$3.26M 0.01%
115,626
-12,574
-10% -$362K
2 3
4
5 6

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Julian Baker's Q4 2020 Portfolio in Review

As of Q4 2020, Julian Baker held 133 positions worth $26.5B, up 6.1% from $25B the previous quarter. Its ten largest holdings account for 84% of the portfolio.

Julian Baker's Q4 2020 filing shows 14 new, 16 increased, 60 reduced and 7 closed positions. Its largest new stake was AbCellera Biologics: 10,450,180 shares worth $421M. The largest sale was BeOne Medicines Ltd, an estimated $450M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • Julian Baker's largest Q4 2020 buy was AbCellera Biologics: 10,450,180 shares worth $421M.
  • Julian Baker added most to Invitae Corporation in Q4 2020, an estimated $181M increase.
  • Julian Baker's biggest Q4 2020 reduction was BeOne Medicines Ltd, cutting an estimated $450M.
  • Julian Baker fully exited MyoKardia, Inc. Common Stock in Q4 2020, selling an estimated $410M.
  • Julian Baker's ten largest holdings make up 84% of its $26.5B portfolio in Q4 2020.
  • Julian Baker opened 14 new positions and closed 7 in Q4 2020.
  • Julian Baker's portfolio value rose 6.1% quarter-over-quarter to $26.5B.

Based on Baker Bros. Advisors's 13F filing for Q4 2020, filed 16 Feb 2021.