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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+49.04%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$18.8B
AUM Growth
+$4.11B
Cap. Flow
-$554M
Cap. Flow %
-2.95%
Top 10 Hldgs %
85.02%
Holding
117
New
8
Increased
21
Reduced
10
Closed
18

Top Buys

Rank Stock Value
1
EXAS
Exact Sciences
EXAS
+$227M
2
DBVT
DBV Technologies
DBVT
+$72.8M
3
KOD icon
Kodiak Sciences
KOD
+$69.2M
4
KRRO icon
Korro Bio
KRRO
+$19.2M
5
AUPH icon
Aurinia Pharmaceuticals
AUPH
+$15.7M

Top Sells

Rank Stock Value
1
GHDX
Genomic Health, Inc.
GHDX
+$627M
2
AMRN
Amarin Corp
AMRN
+$134M
3
ONCE
Spark Therapeutics, Inc. Common Stock
ONCE
+$72.9M
4
NGNE icon
Neurogene
NGNE
+$39.4M
5
CBAY
Cymabay Therapeutics
CBAY
+$29.2M

Sector Composition

Rank Sector Weight
1 Healthcare 99.66%
2 Financials 0.01%
3 Technology 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BLCM
76
DELISTED
Bellicum Pharmaceuticals, Inc.
BLCM
$3.45M 0.02%
267,782
– –
VKTX icon
77
Viking Therapeutics
VKTX
$3.95B
$3.41M 0.02%
425,000
– –
GTHX
78
DELISTED
G1 Therapeutics, Inc. Common Stock
GTHX
$3.36M 0.02%
127,236
– –
YARW
79
Yarrow Bioscience
YARW
$97.2M
$3.25M 0.02%
194
– –
HARP
80
DELISTED
Harpoon Therapeutics, Inc. Common Stock
HARP
$3.17M 0.02%
21,429
– –
LKFT
81
Lakefront Biotherapeutics American Depositary Shares
LKFT
$1.89B
$2.7M 0.01%
13,072
-12,000
-48% -$2.22M
AUTL
82
Autolus Therapeutics
AUTL
$641M
$2.07M 0.01%
156,773
– –
NTLA icon
83
Intellia Therapeutics
NTLA
$1.8B
$1.89M 0.01%
128,538
– –
ANAB icon
84
AnaptysBio
ANAB
$1.71B
$1.84M 0.01%
113,086
– –
CTMX icon
85
CytomX Therapeutics
CTMX
$715M
$1.61M 0.01%
194,377
– –
IDYA icon
86
IDEAYA Biosciences
IDYA
$3.83B
$1.5M 0.01%
200,000
– –
GLMD icon
87
Galmed Pharmaceuticals
GLMD
$4.48M
$1.25M 0.01%
150
– –
RCUS icon
88
Arcus Biosciences
RCUS
$3.86B
$1.23M 0.01%
121,534
– –
ISEE
89
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
$1.22M 0.01%
+141,750
New +$506K
TRIL
90
DELISTED
Trillium Therapeutics Inc.
TRIL
$1.13M 0.01%
1,100,000
+594,738
+118% +$227K
CYPH
91
Cypherpunk Technologies Inc
CYPH
$153M
$1.1M 0.01%
97,845
– –
FSTX
92
DELISTED
F-star Therapeutics, Inc. Common Stock
FSTX
$969K 0.01%
153,286
– –
ADMS
93
DELISTED
Adamas Pharmaceuticals
ADMS
$654K ﹤0.01%
172,630
– –
INFI
94
DELISTED
Infinity Pharmaceuticals, Inc.
INFI
$557K ﹤0.01%
580,400
– –
AFMD
95
DELISTED
Affimed
AFMD
$548K ﹤0.01%
20,000
– –
DVAX
96
DELISTED
Dynavax Technologies
DVAX
$429K ﹤0.01%
75,000
– –
VIRX
97
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$188K ﹤0.01%
15,905
– –
AQST icon
98
Aquestive Therapeutics
AQST
$585M
– –
-99,600
Closed -$317K
CYCN icon
99
Cyclerion Therapeutics
CYCN
$18.2M
– –
-10,129
Closed -$2.46M
HALO icon
100
Halozyme
HALO
$12.3B
– –
-299,969
Closed -$4.65M
1 2 3
4
5

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Julian Baker's Q4 2019 Portfolio in Review

As of Q4 2019, Julian Baker held 117 positions worth $18.8B, up 28% from $14.7B the previous quarter. Its ten largest holdings account for 85% of the portfolio.

Julian Baker's Q4 2019 filing shows 8 new, 21 increased, 10 reduced and 18 closed positions. Its largest new stake was Exact Sciences: 2,585,791 shares worth $239M. The largest sale was Genomic Health, Inc., an estimated $627M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials and Technology.

  • Julian Baker's largest Q4 2019 buy was Exact Sciences: 2,585,791 shares worth $239M.
  • Julian Baker added most to DBV Technologies in Q4 2019, an estimated $72.8M increase.
  • Julian Baker's biggest Q4 2019 reduction was Amarin Corp, cutting an estimated $134M.
  • Julian Baker fully exited Genomic Health, Inc. in Q4 2019, selling an estimated $627M.
  • Julian Baker's ten largest holdings make up 85% of its $18.8B portfolio in Q4 2019.
  • Julian Baker opened 8 new positions and closed 18 in Q4 2019.
  • Julian Baker's portfolio value rose 28% quarter-over-quarter to $18.8B.

Based on Baker Bros. Advisors's 13F filing for Q4 2019, filed 14 Feb 2020.