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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+18.21%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$9.8B
AUM Growth
+$1.86B
Cap. Flow
-$1.4B
Cap. Flow %
-14.24%
Top 10 Hldgs %
73.27%
Holding
123
New
14
Increased
15
Reduced
12
Closed
2

Top Buys

Rank Stock Value
1
AVNR
AVANIR PHARMACEUTICALS, INC CL A
AVNR
+$247M
2
SGEN
Seagen Inc. Common Stock
SGEN
+$188M
3
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$112M
4
BLCM
Bellicum Pharmaceuticals, Inc.
BLCM
+$91.9M
5
SLXP
SALIX PHARMACEUTICALS LTD DEL
SLXP
+$75.9M

Top Sells

Rank Stock Value
1
PCYC
PHARMACYCLICS INC
PCYC
+$67.4M
2
XOMA
Xoma
XOMA
+$26.3M
3
AMBI
Ambit Biosciences Corp
AMBI
+$16.8M
4
MNK
MALLINCKRODT PUBLIC LIMITED COMPANY
MNK
+$14.3M
5
RPRX
Repros Therapeutics Inc.
RPRX
+$6.64M

Sector Composition

Rank Sector Weight
1 Healthcare 47.04%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ZGNX
76
DELISTED
Zogenix, Inc.
ZGNX
$3.22M 0.03%
293,800
– –
SGYP
77
DELISTED
Synergy Pharmaceuticals, Inc Common Stock
SGYP
$2.97M 0.03%
973,245
– –
RCPT
78
DELISTED
RECEPTOS INC COM STK (DE)
RCPT
$2.93M 0.03%
23,900
– –
APTO
79
DELISTED
Aptose Biosciences, Inc.
APTO
$2.83M 0.03%
+1,065
New +$3.2M
FMI
80
DELISTED
Foundation Medicine, Inc.
FMI
$2.8M 0.03%
126,147
+47,985
+61% +$1.11M
SAGE
81
DELISTED
Sage Therapeutics
SAGE
$2.75M 0.03%
75,000
– –
SVRA icon
82
Savara
SVRA
$1.15B
$2.67M 0.03%
68,206
+25,349
+59% +$885K
LPCN icon
83
Lipocine
LPCN
$17.2M
$2.63M 0.03%
29,412
– –
AUPH icon
84
Aurinia Pharmaceuticals
AUPH
$2.22B
$2.6M 0.03%
727,669
– –
BDSI
85
DELISTED
BioDelivery Sciences International, Inc.
BDSI
$2.52M 0.03%
210,021
– –
AFMD
86
DELISTED
Affimed
AFMD
$2.48M 0.03%
40,000
– –
VXRT
87
DELISTED
Vaxart
VXRT
$2.48M 0.03%
100,628
– –
OSUR icon
88
OraSure Technologies
OSUR
$268M
$2.38M 0.02%
234,664
– –
MRNS
89
DELISTED
Marinus Pharmaceuticals, Inc
MRNS
$2.16M 0.02%
51,119
– –
DERM
90
DELISTED
Dermira, Inc.
DERM
$1.81M 0.02%
+100,000
New +$1.67M
TARA icon
91
Protara Therapeutics
TARA
$228M
$1.8M 0.02%
+4,323
New +$1.74M
ISEE
92
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
$1.65M 0.02%
36,776
– –
MDWD icon
93
MediWound
MDWD
$171M
$1.5M 0.02%
32,143
– –
PTN
94
Palatin Technologies
PTN
$17.2M
$1.5M 0.02%
+1,640
New +$1.51M
MDGL icon
95
Madrigal Pharmaceuticals
MDGL
$11.9B
$1.32M 0.01%
14,286
– –
GERN icon
96
Geron
GERN
$977M
$1.31M 0.01%
402,629
– –
AKAO
97
DELISTED
Achaogen Inc
AKAO
$1.3M 0.01%
100,000
– –
LOXO
98
DELISTED
Loxo Oncology, Inc
LOXO
$1.18M 0.01%
100,000
– –
TSRO
99
DELISTED
TESARO, Inc.
TSRO
$1.16M 0.01%
31,218
– –
ALNY icon
100
Alnylam Pharmaceuticals
ALNY
$31.6B
$1.13M 0.01%
11,600
– –
1 2 3
4
5

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Julian Baker's Q4 2014 Portfolio in Review

As of Q4 2014, Julian Baker held 123 positions worth $9.8B, up 23% from $7.94B the previous quarter. Its ten largest holdings account for 73% of the portfolio.

Julian Baker withdrew a net $1.4B in Q4 2014, closing 2 positions and reducing 12 holdings. Its most notable exit was Ambit Biosciences Corp, an estimated $16.8M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 47% of assets, up from 44% a quarter earlier.

Against the trend, Julian Baker opened a new position in Bellicum Pharmaceuticals, Inc. worth $98.7M.

  • Julian Baker's largest Q4 2014 buy was Bellicum Pharmaceuticals, Inc.: 428,373 shares worth $98.7M.
  • Julian Baker added most to AVANIR PHARMACEUTICALS, INC CL A in Q4 2014, an estimated $247M increase.
  • Julian Baker's biggest Q4 2014 reduction was PHARMACYCLICS INC, cutting an estimated $67.4M.
  • Julian Baker fully exited Ambit Biosciences Corp in Q4 2014, selling an estimated $16.8M.
  • Julian Baker's ten largest holdings make up 73% of its $9.8B portfolio in Q4 2014.
  • Julian Baker opened 14 new positions and closed 2 in Q4 2014.
  • Julian Baker's portfolio value rose 23% quarter-over-quarter to $9.8B.

Based on Baker Bros. Advisors's 13F filing for Q4 2014, filed 17 Feb 2015.