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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+23.73%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$8.79B
AUM Growth
-$8.56B
Cap. Flow
-$9.86B
Cap. Flow %
-112.21%
Top 10 Hldgs %
80.97%
Holding
105
New
4
Increased
25
Reduced
11
Closed
21

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$152M
2
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$74.3M
3
RVMD icon
Revolution Medicines
RVMD
+$59M
4
REPL icon
Replimune Group
REPL
+$57.6M
5
CERE
Cerevel Therapeutics Holdings, Inc. Common Stock
CERE
+$46M

Top Sells

Rank Stock Value
1
SGEN
Seagen Inc. Common Stock
SGEN
+$9.45B
2
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$337M
3
ONC
BeOne Medicines Ltd
ONC
+$199M
4
SWTX
SpringWorks Therapeutics
SWTX
+$69.4M
5
ROIV icon
Roivant Sciences
ROIV
+$41.8M

Sector Composition

Rank Sector Weight
1 Healthcare 98.38%
2 Financials 0.06%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SANA icon
51
Sana Biotechnology
SANA
$1.17B
$8.16M 0.09%
2,000,000
– –
SGMT icon
52
Sagimet Biosciences
SGMT
$637M
$7.89M 0.09%
1,456,518
+641,159
+79% +$3.02M
CELC icon
53
Celcuity
CELC
$4.58B
$7.8M 0.09%
535,478
– –
LONA
54
LeonaBio Inc
LONA
$72.4M
$7.66M 0.09%
315,381
– –
OPT
55
DELISTED
Opthea Limited American Depositary Shares
OPT
$7.64M 0.09%
2,588,645
-102,246
-4% -$213K
TNGX icon
56
Tango Therapeutics
TNGX
$4.03B
$7.42M 0.08%
750,000
– –
TSHA icon
57
Taysha Gene Therapies
TSHA
$1.98B
$7.09M 0.08%
4,004,756
+1,500,000
+60% +$2.99M
HOOK
58
DELISTED
HOOKIPA Pharma
HOOK
$6.58M 0.07%
812,815
+6,275
+0.8% +$34.6K
MIRM icon
59
Mirum Pharmaceuticals
MIRM
$5.87B
$5.62M 0.06%
190,476
– –
XNCR icon
60
Xencor
XNCR
$2.07B
$5.21M 0.06%
245,431
+122,304
+99% +$2.33M
CYPH
61
Cypherpunk Technologies Inc
CYPH
$153M
$4.86M 0.06%
1,172,175
– –
DSGN icon
62
Design Therapeutics
DSGN
$938M
$3.98M 0.05%
1,500,000
– –
TLIS
63
DELISTED
Talis Biomedical Corporation Common Stock
TLIS
$3.79M 0.04%
508,323
– –
CATX icon
64
Perspective Therapeutics
CATX
$377M
$3.07M 0.03%
763,970
– –
PCVX icon
65
Vaxcyte
PCVX
$9.32B
$3.07M 0.03%
48,885
– –
PRAX icon
66
Praxis Precision Medicines
PRAX
$10.5B
$2.93M 0.03%
131,533
+6,205
+5% +$112K
IPSC icon
67
Century Therapeutics
IPSC
$375M
$2.65M 0.03%
797,460
-351,880
-31% -$641K
MRSN
68
DELISTED
Mersana Therapeutics
MRSN
$2.52M 0.03%
43,445
– –
CMPX icon
69
Compass Therapeutics
CMPX
$432M
$2.43M 0.03%
1,557,630
– –
ACHL
70
DELISTED
Achilles Therapeutics
ACHL
$1.87M 0.02%
2,102,792
-454,357
-18% -$390K
KALA icon
71
KALA BIO
KALA
$15.9M
$1.87M 0.02%
5,332
– –
ALGS icon
72
Aligos Therapeutics
ALGS
$41.7M
$1.38M 0.02%
83,056
– –
NVTA
73
DELISTED
Invitae Corporation
NVTA
$1.11M 0.01%
1,764,546
– –
PFE icon
74
Pfizer
PFE
$160B
$1.01M 0.01%
+35,000
New +$1.06M
PMVP icon
75
PMV Pharmaceuticals
PMVP
$71.1M
$998K 0.01%
322,024
– –
1 2
3
4 5

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Julian Baker's Q4 2023 Portfolio in Review

As of Q4 2023, Julian Baker held 105 positions worth $8.79B, down 49% from $17.4B the previous quarter. Its ten largest holdings account for 81% of the portfolio.

Julian Baker withdrew a net $9.86B in Q4 2023, closing 21 positions and reducing 11 holdings. Its most notable exit was Seagen Inc. Common Stock, an estimated $9.45B position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 99% a quarter earlier, followed by Financials.

Against the trend, Julian Baker opened a new position in Cerevel Therapeutics Holdings, Inc. Common Stock worth $67.8M.

  • Julian Baker's largest Q4 2023 buy was Cerevel Therapeutics Holdings, Inc. Common Stock: 1,600,000 shares worth $67.8M.
  • Julian Baker added most to Mirati Therapeutics, Inc. Common Stock in Q4 2023, an estimated $152M increase.
  • Julian Baker's biggest Q4 2023 reduction was BeOne Medicines Ltd, cutting an estimated $199M.
  • Julian Baker fully exited Seagen Inc. Common Stock in Q4 2023, selling an estimated $9.45B.
  • Julian Baker's ten largest holdings make up 81% of its $8.79B portfolio in Q4 2023.
  • Julian Baker opened 4 new positions and closed 21 in Q4 2023.
  • Julian Baker's portfolio value fell 49% quarter-over-quarter to $8.79B.

Based on Baker Bros. Advisors's 13F filing for Q4 2023, filed 14 Feb 2024.