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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
-1.31%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$15.3B
AUM Growth
-$2.36B
Cap. Flow
-$405M
Cap. Flow %
-2.65%
Top 10 Hldgs %
84.69%
Holding
128
New
12
Increased
7
Reduced
17
Closed
13

Top Buys

Rank Stock Value
1
RYTM icon
Rhythm Pharmaceuticals
RYTM
+$36M
2
AKRO
Akero Therapeutics
AKRO
+$34.4M
3
VERU icon
Veru
VERU
+$23.2M
4
CINC
CinCor Pharma, Inc. Common Stock
CINC
+$22.8M
5
IDYA icon
IDEAYA Biosciences
IDYA
+$21.7M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$311M
2
INSM icon
Insmed
INSM
+$51.2M
3
LEGN icon
Legend Biotech
LEGN
+$47.1M
4
KRYS icon
Krystal Biotech
KRYS
+$27.9M
5
PACB icon
Pacific Biosciences
PACB
+$24.8M

Sector Composition

Rank Sector Weight
1 Healthcare 99.7%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
DNLI icon
51
Denali Therapeutics
DNLI
$3.98B
$18.1M 0.12%
588,738
– –
OPT
52
DELISTED
Opthea Limited American Depositary Shares
OPT
$16.7M 0.11%
2,691,391
-4,800
-0.2% -$30.8K
BLUE
53
DELISTED
bluebird bio
BLUE
$15.8M 0.1%
124,986
– –
CRNX icon
54
Crinetics Pharmaceuticals
CRNX
$8.99B
$14.4M 0.09%
735,716
-91,764
-11% -$1.87M
WHWK
55
Whitehawk Therapeutics
WHWK
$270M
$14M 0.09%
+989,928
New +$13M
TCDA
56
DELISTED
Tricida, Inc. Common Stock
TCDA
$13.8M 0.09%
1,320,290
-182,800
-12% -$2M
AFMD
57
DELISTED
Affimed
AFMD
$13.6M 0.09%
659,683
– –
DICE
58
DELISTED
DICE Therapeutics, Inc. Common Stock
DICE
$11.9M 0.08%
588,235
– –
ANAB icon
59
AnaptysBio
ANAB
$1.71B
$10.9M 0.07%
427,179
– –
KYNB
60
Kyntra Bio
KYNB
$30.4M
$10.6M 0.07%
32,629
– –
ADAP
61
DELISTED
Adaptimmune Therapeutics
ADAP
$10.6M 0.07%
9,830,877
– –
ZYME icon
62
Zymeworks
ZYME
$2.05B
$10.5M 0.07%
1,708,472
– –
PNT
63
DELISTED
POINT Biopharma Global Inc. Common Stock
PNT
$9.04M 0.06%
+1,169,103
New +$9.92M
TCRX icon
64
TScan Therapeutics
TCRX
$52.8M
$8.49M 0.06%
2,784,792
– –
CBAY
65
DELISTED
Cymabay Therapeutics
CBAY
$7.6M 0.05%
2,170,464
– –
VERA icon
66
Vera Therapeutics
VERA
$2.33B
$7.1M 0.05%
333,333
– –
PACB icon
67
Pacific Biosciences
PACB
$420M
$6.55M 0.04%
1,127,782
-4,317,181
-79% -$24.8M
FLGT icon
68
Fulgent Genetics
FLGT
$548M
$6.35M 0.04%
166,619
-34,825
-17% -$1.75M
AMRN
69
Amarin Corp
AMRN
$298M
$5.86M 0.04%
268,856
-789,634
-75% -$21.2M
ACHL
70
DELISTED
Achilles Therapeutics
ACHL
$5.86M 0.04%
2,591,366
– –
VOR icon
71
Vor Biopharma
VOR
$1.38B
$5.83M 0.04%
73,296
+16,358
+29% +$1.61M
RETA
72
DELISTED
Reata Pharmaceuticals, Inc. Class A Common Stock
RETA
$5.63M 0.04%
223,976
– –
BCEL
73
DELISTED
Atreca, Inc. Class A Common Stock
BCEL
$5.55M 0.04%
3,532,760
– –
NKTX icon
74
Nkarta
NKTX
$191M
$5.26M 0.03%
400,000
– –
TLIS
75
DELISTED
Talis Biomedical Corporation Common Stock
TLIS
$5.2M 0.03%
508,322
– –
1 2
3
4 5

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Julian Baker's Q3 2022 Portfolio in Review

As of Q3 2022, Julian Baker held 128 positions worth $15.3B, down 13% from $17.6B the previous quarter. Its ten largest holdings account for 85% of the portfolio.

Julian Baker's Q3 2022 filing shows 12 new, 7 increased, 17 reduced and 13 closed positions. Its largest new stake was Veru: 160,958 shares worth $18.5M. The largest sale was argenx, an estimated $311M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • Julian Baker's largest Q3 2022 buy was Veru: 160,958 shares worth $18.5M.
  • Julian Baker added most to Rhythm Pharmaceuticals in Q3 2022, an estimated $36M increase.
  • Julian Baker's biggest Q3 2022 reduction was argenx, cutting an estimated $311M.
  • Julian Baker fully exited Legend Biotech in Q3 2022, selling an estimated $47.1M.
  • Julian Baker's ten largest holdings make up 85% of its $15.3B portfolio in Q3 2022.
  • Julian Baker opened 12 new positions and closed 13 in Q3 2022.
  • Julian Baker's portfolio value fell 13% quarter-over-quarter to $15.3B.

Based on Baker Bros. Advisors's 13F filing for Q3 2022, filed 14 Nov 2022.