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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
-9.09%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$17.4B
AUM Growth
-$3.15B
Cap. Flow
+$225M
Cap. Flow %
1.29%
Top 10 Hldgs %
85.01%
Holding
121
New
2
Increased
15
Reduced
4
Closed
3

Top Buys

Rank Stock Value
1
INCY icon
Incyte
INCY
+$184M
2
KOD icon
Kodiak Sciences
KOD
+$48.8M
3
HZNP
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
+$29.2M
4
TSVT
2seventy bio
TSVT
+$20.9M
5
REPL icon
Replimune Group
REPL
+$19.2M

Top Sells

Rank Stock Value
1
CCXI
ChemoCentryx, Inc.
CCXI
+$20.1M
2
LEGN icon
Legend Biotech
LEGN
+$19M
3
OPT
Opthea Limited American Depositary Shares
OPT
+$3.19M
4
ALBO
Albireo Pharma Inc
ALBO
+$2.43M
5
GMDA
Gamida Cell Ltd. Ordinary Shares
GMDA
+$1.55M

Sector Composition

Rank Sector Weight
1 Healthcare 99.5%
2 Financials 0.01%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
FMTX
51
DELISTED
Forma Therapeutics Holdings, Inc. Common Stock
FMTX
$18.8M 0.11%
2,024,876
– –
OTIC
52
DELISTED
Otonomy, Inc.
OTIC
$18.8M 0.11%
7,844,692
– –
OPT
53
DELISTED
Opthea Limited American Depositary Shares
OPT
$18.5M 0.11%
2,696,191
-500,000
-16% -$3.19M
CRNX icon
54
Crinetics Pharmaceuticals
CRNX
$8.99B
$18.2M 0.1%
827,480
– –
TCDA
55
DELISTED
Tricida, Inc. Common Stock
TCDA
$14.2M 0.08%
1,731,714
+446,700
+35% +$4.04M
RLMD icon
56
Relmada Therapeutics
RLMD
$494M
$13.4M 0.08%
495,113
– –
FLGT icon
57
Fulgent Genetics
FLGT
$548M
$12.6M 0.07%
201,444
– –
BLUE
58
DELISTED
bluebird bio
BLUE
$12.1M 0.07%
124,986
– –
DICE
59
DELISTED
DICE Therapeutics, Inc. Common Stock
DICE
$11.3M 0.06%
588,235
– –
BCEL
60
DELISTED
Atreca, Inc. Class A Common Stock
BCEL
$11.2M 0.06%
3,532,760
– –
ZYME icon
61
Zymeworks
ZYME
$2.05B
$11.2M 0.06%
1,708,472
– –
LONA
62
LeonaBio Inc
LONA
$72.4M
$10.9M 0.06%
80,637
– –
TLIS
63
DELISTED
Talis Biomedical Corporation Common Stock
TLIS
$10.8M 0.06%
508,322
– –
ANAB icon
64
AnaptysBio
ANAB
$1.71B
$10.6M 0.06%
427,179
– –
CNTA
65
DELISTED
Centessa Pharmaceuticals
CNTA
$10.1M 0.06%
1,127,273
– –
SRPT icon
66
Sarepta Therapeutics
SRPT
$1.98B
$9.64M 0.06%
123,456
– –
KRTX
67
DELISTED
Karuna Therapeutics, Inc. Common Stock
KRTX
$8.87M 0.05%
69,966
– –
SYRE icon
68
Spyre Therapeutics
SYRE
$9.39B
$7.84M 0.05%
136,404
– –
VERA icon
69
Vera Therapeutics
VERA
$2.33B
$7.83M 0.05%
+333,333
New +$7.17M
ACHL
70
DELISTED
Achilles Therapeutics
ACHL
$7.62M 0.04%
2,591,366
– –
SRZN icon
71
Surrozen
SRZN
$282M
$7.53M 0.04%
166,667
– –
RETA
72
DELISTED
Reata Pharmaceuticals, Inc. Class A Common Stock
RETA
$7.34M 0.04%
223,976
– –
NGNE icon
73
Neurogene
NGNE
$773M
$7.18M 0.04%
191,087
– –
KYNB
74
Kyntra Bio
KYNB
$30.4M
$6.99M 0.04%
23,270
+64
+0.3% +$22.3K
BMEA icon
75
Biomea Fusion
BMEA
$99.3M
$6.92M 0.04%
1,551,445
+1,026,828
+196% +$6.66M
1 2
3
4 5

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Julian Baker's Q1 2022 Portfolio in Review

As of Q1 2022, Julian Baker held 121 positions worth $17.4B, down 15% from $20.6B the previous quarter. Its ten largest holdings account for 85% of the portfolio.

Trading was light in Q1 2022: portfolio turnover was 4.1%. Julian Baker opened 2 new positions and exited 3, leaving the 121-position portfolio largely intact.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 99% a quarter earlier, followed by Financials.

  • Julian Baker's largest Q1 2022 buy was Vera Therapeutics: 333,333 shares worth $7.83M.
  • Julian Baker added most to Incyte in Q1 2022, an estimated $184M increase.
  • Julian Baker's biggest Q1 2022 reduction was ChemoCentryx, Inc., cutting an estimated $20.1M.
  • Julian Baker fully exited Albireo Pharma Inc in Q1 2022, selling an estimated $2.43M.
  • Julian Baker's ten largest holdings make up 85% of its $17.4B portfolio in Q1 2022.
  • Julian Baker opened 2 new positions and closed 3 in Q1 2022.
  • Julian Baker's portfolio value fell 15% quarter-over-quarter to $17.4B.

Based on Baker Bros. Advisors's 13F filing for Q1 2022, filed 16 May 2022.