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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+13.19%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$12.1B
AUM Growth
+$1.25B
Cap. Flow
-$1.53B
Cap. Flow %
-12.71%
Top 10 Hldgs %
75.84%
Holding
141
New
6
Increased
25
Reduced
5
Closed
8

Top Buys

Rank Stock Value
1
ACOR
Acorda Therapeutics
ACOR
+$90.4M
2
SGEN
Seagen Inc. Common Stock
SGEN
+$52.6M
3
DYAX
DYAX CORPORATION
DYAX
+$24.1M
4
ALKS icon
Alkermes
ALKS
+$17.5M
5
AAAP
Advanced Accelerator Applications S.A.
AAAP
+$15.8M

Top Sells

Rank Stock Value
1
CLVS
Clovis Oncology, Inc.
CLVS
+$18.6M
2
XNPT
XENOPORT, INC.
XNPT
+$17M
3
ALDR
Alder Biopharmaceuticals
ALDR
+$16.8M
4
RPRX
Repros Therapeutics Inc.
RPRX
+$14.5M
5
LRMR icon
Larimar Therapeutics
LRMR
+$12.5M

Sector Composition

Rank Sector Weight
1 Healthcare 78.52%
2 Technology 0.01%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
DERM
51
DELISTED
Dermira, Inc.
DERM
$9.52M 0.08%
275,000
– –
CNCE
52
DELISTED
Concert Pharmaceuticals, Inc.
CNCE
$9.41M 0.08%
495,908
– –
ASND icon
53
Ascendis Pharma A/S
ASND
$16.6B
$9.26M 0.08%
505,521
+69,981
+16% +$1.23M
BLUE
54
DELISTED
bluebird bio
BLUE
$9.06M 0.08%
10,893
– –
PRQR icon
55
ProQR Therapeutics
PRQR
$330M
$8.58M 0.07%
988,299
– –
LGND icon
56
Ligand Pharmaceuticals
LGND
$5.71B
$7.96M 0.07%
117,638
– –
RXDX
57
DELISTED
Ignyta, Inc.
RXDX
$7.65M 0.06%
571,000
– –
AERI
58
DELISTED
Aerie Pharmaceuticals
AERI
$7.29M 0.06%
299,356
– –
ECYT
59
DELISTED
Endocyte, Inc. Common Stock
ECYT
$6.8M 0.06%
1,695,865
+339,313
+25% +$1.56M
AGIO icon
60
Agios Pharmaceuticals
AGIO
$1.98B
$6.49M 0.05%
100,000
– –
ARWR icon
61
Arrowhead Research
ARWR
$12.3B
$6.21M 0.05%
1,009,509
– –
SAGE
62
DELISTED
Sage Therapeutics
SAGE
$6.12M 0.05%
105,000
– –
CRIS icon
63
Curis
CRIS
$3.83M
$5.82M 0.05%
1,000
– –
AKTX
64
Akari Therapeutics
AKTX
$15.3M
$5.74M 0.05%
495
– –
OMER icon
65
Omeros
OMER
$1.39B
$5.29M 0.04%
336,226
– –
NDRM
66
DELISTED
NeuroDerm Ltd. Ordinary Shares
NDRM
$5.2M 0.04%
305,000
– –
OSIR
67
DELISTED
Osiris Therapeutics, Inc. Common Stock
OSIR
$5.18M 0.04%
499,193
– –
TRVN
68
DELISTED
Trevena, Inc.
TRVN
$4.72M 0.04%
720
– –
TARA icon
69
Protara Therapeutics
TARA
$228M
$4.63M 0.04%
7,465
+600
+9% +$352K
AIMT
70
DELISTED
Aimmune Therapeutics
AIMT
$4.61M 0.04%
250,000
– –
GNMX
71
DELISTED
Aevi Genomic Medicine Inc
GNMX
$4.61M 0.04%
+765,000
New +$5.19M
MCRB icon
72
Seres Therapeutics
MCRB
$45.8M
$4.39M 0.04%
6,250
– –
AMRN
73
Amarin Corp
AMRN
$298M
$4.17M 0.03%
110,286
– –
VIRX
74
DELISTED
Viracta Therapeutics, Inc. Common Stock
VIRX
$3.99M 0.03%
21,190
+5,952
+39% +$1.11M
LOXO
75
DELISTED
Loxo Oncology, Inc
LOXO
$3.92M 0.03%
137,735
+37,735
+38% +$1.01M
1 2
3
4 5

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Julian Baker's Q4 2015 Portfolio in Review

As of Q4 2015, Julian Baker held 141 positions worth $12.1B, up 12% from $10.8B the previous quarter. Its ten largest holdings account for 76% of the portfolio.

Julian Baker withdrew a net $1.53B in Q4 2015, closing 8 positions and reducing 5 holdings. Its most notable exit was Clovis Oncology, Inc., an estimated $18.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 79% of assets, up from 78% a quarter earlier, followed by Technology.

Against the trend, Julian Baker opened a new position in Alkermes worth $19.9M.

  • Julian Baker's largest Q4 2015 buy was Alkermes: 250,251 shares worth $19.9M.
  • Julian Baker added most to Acorda Therapeutics in Q4 2015, an estimated $90.4M increase.
  • Julian Baker's biggest Q4 2015 reduction was XENOPORT, INC., cutting an estimated $17M.
  • Julian Baker fully exited Clovis Oncology, Inc. in Q4 2015, selling an estimated $18.6M.
  • Julian Baker's ten largest holdings make up 76% of its $12.1B portfolio in Q4 2015.
  • Julian Baker opened 6 new positions and closed 8 in Q4 2015.
  • Julian Baker's portfolio value rose 12% quarter-over-quarter to $12.1B.

Based on Baker Bros. Advisors's 13F filing for Q4 2015, filed 16 Feb 2016.