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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+18.21%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$9.8B
AUM Growth
+$1.86B
Cap. Flow
-$1.4B
Cap. Flow %
-14.24%
Top 10 Hldgs %
73.27%
Holding
123
New
14
Increased
15
Reduced
12
Closed
2

Top Buys

Rank Stock Value
1
AVNR
AVANIR PHARMACEUTICALS, INC CL A
AVNR
+$247M
2
SGEN
Seagen Inc. Common Stock
SGEN
+$188M
3
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$112M
4
BLCM
Bellicum Pharmaceuticals, Inc.
BLCM
+$91.9M
5
SLXP
SALIX PHARMACEUTICALS LTD DEL
SLXP
+$75.9M

Top Sells

Rank Stock Value
1
PCYC
PHARMACYCLICS INC
PCYC
+$67.4M
2
XOMA
Xoma
XOMA
+$26.3M
3
AMBI
Ambit Biosciences Corp
AMBI
+$16.8M
4
MNK
MALLINCKRODT PUBLIC LIMITED COMPANY
MNK
+$14.3M
5
RPRX
Repros Therapeutics Inc.
RPRX
+$6.64M

Sector Composition

Rank Sector Weight
1 Healthcare 47.04%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
FOMX
51
DELISTED
Foamix Pharmaceuticals Ltd. Ordinary Shares
FOMX
$7.16M 0.07%
1,021,600
– –
CMRX
52
DELISTED
Chimerix, Inc.
CMRX
$6.94M 0.07%
+172,414
New +$5.84M
MTEM
53
DELISTED
Molecular Templates, Inc.
MTEM
$6.86M 0.07%
13,064
-16
-0.1% -$8K
ARRY
54
DELISTED
Array Biopharma Inc
ARRY
$6.78M 0.07%
1,433,797
– –
CNCE
55
DELISTED
Concert Pharmaceuticals, Inc.
CNCE
$6.73M 0.07%
505,418
+53,922
+12% +$696K
RARE icon
56
Ultragenyx Pharmaceutical
RARE
$2.55B
$6.58M 0.07%
150,000
– –
QLTI
57
DELISTED
QLT Inc
QLTI
$6.16M 0.06%
1,535,863
– –
IONS icon
58
Ionis Pharmaceuticals
IONS
$9.93B
$5.95M 0.06%
96,303
– –
STML
59
DELISTED
Stemline Therapeutics, Inc.
STML
$5.78M 0.06%
338,671
– –
ACHN
60
DELISTED
Achillion Pharmaceuticals
ACHN
$5.37M 0.05%
438,337
– –
IRWD icon
61
Ironwood Pharmaceuticals
IRWD
$709M
$5.3M 0.05%
413,315
– –
INFI
62
DELISTED
Infinity Pharmaceuticals, Inc.
INFI
$5.27M 0.05%
312,025
– –
JUNO
63
DELISTED
Juno Therapeutics, Inc.
JUNO
$5.22M 0.05%
+100,000
New +$4.48M
MNK
64
DELISTED
MALLINCKRODT PUBLIC LIMITED COMPANY
MNK
$4.62M 0.05%
46,666
-155,190
-77% -$14.3M
ALDR
65
DELISTED
Alder Biopharmaceuticals
ALDR
$4.46M 0.05%
153,350
– –
WINT
66
DELISTED
Windtree Therapeutics Inc
WINT
$4.24M 0.04%
260,866
– –
FOLD
67
DELISTED
Amicus Therapeutics
FOLD
$4.01M 0.04%
481,697
– –
RXDX
68
DELISTED
Ignyta, Inc.
RXDX
$3.91M 0.04%
571,000
– –
LGND icon
69
Ligand Pharmaceuticals
LGND
$5.71B
$3.91M 0.04%
117,660
– –
ENTA icon
70
Enanta Pharmaceuticals
ENTA
$392M
$3.83M 0.04%
75,357
– –
EPZM
71
DELISTED
Epizyme, Inc
EPZM
$3.81M 0.04%
201,963
-12,049
-6% -$281K
CYTR
72
DELISTED
CytRx Corp
CYTR
$3.7M 0.04%
225,000
– –
KPTI icon
73
Karyopharm Therapeutics
KPTI
$44.5M
$3.52M 0.04%
6,273
– –
NDRM
74
DELISTED
NeuroDerm Ltd. Ordinary Shares
NDRM
$3.51M 0.04%
+250,000
New +$1.98M
AKTX
75
Akari Therapeutics
AKTX
$15.3M
$3.23M 0.03%
84
– –
1 2
3
4 5

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Julian Baker's Q4 2014 Portfolio in Review

As of Q4 2014, Julian Baker held 123 positions worth $9.8B, up 23% from $7.94B the previous quarter. Its ten largest holdings account for 73% of the portfolio.

Julian Baker withdrew a net $1.4B in Q4 2014, closing 2 positions and reducing 12 holdings. Its most notable exit was Ambit Biosciences Corp, an estimated $16.8M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 47% of assets, up from 44% a quarter earlier.

Against the trend, Julian Baker opened a new position in Bellicum Pharmaceuticals, Inc. worth $98.7M.

  • Julian Baker's largest Q4 2014 buy was Bellicum Pharmaceuticals, Inc.: 428,373 shares worth $98.7M.
  • Julian Baker added most to AVANIR PHARMACEUTICALS, INC CL A in Q4 2014, an estimated $247M increase.
  • Julian Baker's biggest Q4 2014 reduction was PHARMACYCLICS INC, cutting an estimated $67.4M.
  • Julian Baker fully exited Ambit Biosciences Corp in Q4 2014, selling an estimated $16.8M.
  • Julian Baker's ten largest holdings make up 73% of its $9.8B portfolio in Q4 2014.
  • Julian Baker opened 14 new positions and closed 2 in Q4 2014.
  • Julian Baker's portfolio value rose 23% quarter-over-quarter to $9.8B.

Based on Baker Bros. Advisors's 13F filing for Q4 2014, filed 17 Feb 2015.