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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
-6.18%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$20.6B
AUM Growth
-$2.22B
Cap. Flow
+$62.6M
Cap. Flow %
0.3%
Top 10 Hldgs %
83.49%
Holding
126
New
5
Increased
17
Reduced
8
Closed
5

Top Buys

Rank Stock Value
1
TRDA icon
Entrada Therapeutics
TRDA
+$114M
2
INCY icon
Incyte
INCY
+$108M
3
CCXI
ChemoCentryx, Inc.
CCXI
+$46.7M
4
TSVT
2seventy bio
TSVT
+$26M
5
TVTX icon
Travere Therapeutics
TVTX
+$17.7M

Top Sells

Rank Stock Value
1
SGEN
Seagen Inc. Common Stock
SGEN
+$66.1M
2
FLGT icon
Fulgent Genetics
FLGT
+$17.5M
3
BLUE
bluebird bio
BLUE
+$16M
4
MIRM icon
Mirum Pharmaceuticals
MIRM
+$12.9M
5
AUPH icon
Aurinia Pharmaceuticals
AUPH
+$11.5M

Sector Composition

Rank Sector Weight
1 Healthcare 99.22%
2 Financials 0.01%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
NRIX icon
26
Nurix Therapeutics
NRIX
$2.77B
$71M 0.35%
2,454,082
– –
TIL icon
27
Instil Bio
TIL
$51.4M
$66.6M 0.32%
194,685
– –
MRUS
28
DELISTED
Merus
MRUS
$64.8M 0.32%
2,037,469
– –
HZNP
29
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
$64.6M 0.31%
599,110
– –
IMTX icon
30
Immatics
IMTX
$1.22B
$59.5M 0.29%
4,423,731
– –
CCXI
31
DELISTED
ChemoCentryx, Inc.
CCXI
$59.4M 0.29%
1,631,266
+1,330,071
+442% +$46.7M
INSM icon
32
Insmed
INSM
$27.5B
$58.7M 0.29%
2,156,001
– –
NBIX icon
33
Neurocrine Biosciences
NBIX
$15.5B
$57.7M 0.28%
676,975
– –
KRYS icon
34
Krystal Biotech
KRYS
$10.3B
$56.5M 0.27%
807,735
+200,000
+33% +$11.6M
VERV
35
DELISTED
Verve Therapeutics
VERV
$52.2M 0.25%
1,416,530
– –
VSTM icon
36
Verastem
VSTM
$624M
$44.1M 0.21%
1,790,969
– –
RYTM icon
37
Rhythm Pharmaceuticals
RYTM
$7.57B
$38.6M 0.19%
3,863,239
– –
KDNY
38
DELISTED
Chinook Therapeutics, Inc. Common Stock
KDNY
$38.1M 0.19%
2,334,102
+431,033
+23% +$6.14M
RARE icon
39
Ultragenyx Pharmaceutical
RARE
$2.55B
$37.4M 0.18%
444,444
– –
ADAP
40
DELISTED
Adaptimmune Therapeutics
ADAP
$36.9M 0.18%
9,830,877
– –
ALKS icon
41
Alkermes
ALKS
$8.11B
$34.9M 0.17%
1,500,000
+271,830
+22% +$7.15M
KNSA icon
42
Kiniksa Pharmaceuticals
KNSA
$6.17B
$33M 0.16%
2,799,577
– –
DSGN icon
43
Design Therapeutics
DSGN
$938M
$30.8M 0.15%
1,436,636
– –
TLIS
44
DELISTED
Talis Biomedical Corporation Common Stock
TLIS
$30.6M 0.15%
508,322
+3,333
+0.7% +$249K
FMTX
45
DELISTED
Forma Therapeutics Holdings, Inc. Common Stock
FMTX
$28.8M 0.14%
2,024,876
– –
ZYME icon
46
Zymeworks
ZYME
$2.05B
$28M 0.14%
1,708,472
– –
BLUE
47
DELISTED
bluebird bio
BLUE
$25M 0.12%
124,986
-67,992
-35% -$16M
ALGS icon
48
Aligos Therapeutics
ALGS
$41.7M
$24.6M 0.12%
83,056
– –
OPT
49
DELISTED
Opthea Limited American Depositary Shares
OPT
$24.1M 0.12%
3,196,191
-186,606
-6% -$1.36M
CRNX icon
50
Crinetics Pharmaceuticals
CRNX
$8.99B
$23.5M 0.11%
827,480
-93,176
-10% -$2.3M
1
2
3 4 5

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Julian Baker's Q4 2021 Portfolio in Review

As of Q4 2021, Julian Baker held 126 positions worth $20.6B, down 9.7% from $22.8B the previous quarter. Its ten largest holdings account for 83% of the portfolio.

Julian Baker's Q4 2021 filing shows 5 new, 17 increased, 8 reduced and 5 closed positions. Its largest new stake was Entrada Therapeutics: 4,704,419 shares worth $80.5M. The largest sale was Seagen Inc. Common Stock, an estimated $66.1M.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, up from 99% a quarter earlier, followed by Financials.

  • Julian Baker's largest Q4 2021 buy was Entrada Therapeutics: 4,704,419 shares worth $80.5M.
  • Julian Baker added most to Incyte in Q4 2021, an estimated $108M increase.
  • Julian Baker's biggest Q4 2021 reduction was Seagen Inc. Common Stock, cutting an estimated $66.1M.
  • Julian Baker fully exited Mirum Pharmaceuticals in Q4 2021, selling an estimated $12.9M.
  • Julian Baker's ten largest holdings make up 83% of its $20.6B portfolio in Q4 2021.
  • Julian Baker opened 5 new positions and closed 5 in Q4 2021.
  • Julian Baker's portfolio value fell 9.7% quarter-over-quarter to $20.6B.

Based on Baker Bros. Advisors's 13F filing for Q4 2021, filed 14 Feb 2022.