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JB

Julian Baker Baker Bros. Advisors

AUM $20B
1-Year Est. Return 154.41%
 

Julian Baker is co-managing member of Baker Bros. Advisors, a firm renowned for deep specialization in biotechnology and life sciences. The firm is known for concentrated positions, long holding periods, and scientific diligence that goes well beyond typical generalist research. Baker Bros. filings are closely watched by healthcare investors for signals in clinical-stage and commercial biotech.

This Fund
S&P 500
This Quarter Est. Return
+49.04%
1 Year Est. Return
+154.41%
3 Year Est. Return
+448.58%
5 Year Est. Return
+670.61%
10 Year Est. Return
+4,743.65%
AUM
$18.8B
AUM Growth
+$4.11B
Cap. Flow
-$554M
Cap. Flow %
-2.95%
Top 10 Hldgs %
85.02%
Holding
117
New
8
Increased
21
Reduced
10
Closed
18

Top Buys

Rank Stock Value
1
EXAS
Exact Sciences
EXAS
+$227M
2
DBVT
DBV Technologies
DBVT
+$72.8M
3
KOD icon
Kodiak Sciences
KOD
+$69.2M
4
KRRO icon
Korro Bio
KRRO
+$19.2M
5
AUPH icon
Aurinia Pharmaceuticals
AUPH
+$15.7M

Top Sells

Rank Stock Value
1
GHDX
Genomic Health, Inc.
GHDX
+$627M
2
AMRN
Amarin Corp
AMRN
+$134M
3
ONCE
Spark Therapeutics, Inc. Common Stock
ONCE
+$72.9M
4
NGNE icon
Neurogene
NGNE
+$39.4M
5
CBAY
Cymabay Therapeutics
CBAY
+$29.2M

Sector Composition

Rank Sector Weight
1 Healthcare 99.66%
2 Financials 0.01%
3 Technology 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
INSM icon
26
Insmed
INSM
$27.5B
$58.4M 0.31%
2,445,265
+215,505
+10% +$4.38M
KRYS icon
27
Krystal Biotech
KRYS
$10.3B
$57.3M 0.3%
1,034,674
– –
BCEL
28
DELISTED
Atreca, Inc. Class A Common Stock
BCEL
$54.7M 0.29%
3,532,760
– –
BOLD
29
DELISTED
Audentes Therapeutics, Inc
BOLD
$48.2M 0.26%
804,720
-701,718
-47% -$26.3M
CERS icon
30
Cerus
CERS
$566M
$45.4M 0.24%
10,749,937
– –
NGNE icon
31
Neurogene
NGNE
$773M
$41.9M 0.22%
169,887
-395,397
-70% -$39.4M
GWPH
32
DELISTED
GW Pharmaceuticals Plc American Depositary Shares
GWPH
$38.8M 0.21%
370,845
– –
BCRX icon
33
BioCryst Pharmaceuticals
BCRX
$2.44B
$37.8M 0.2%
10,946,166
-1,779,306
-14% -$4.48M
QURE icon
34
uniQure
QURE
$3.36B
$37.1M 0.2%
517,700
– –
AUPH icon
35
Aurinia Pharmaceuticals
AUPH
$2.22B
$34.5M 0.18%
+1,701,929
New +$15.7M
ADPT icon
36
Adaptive Biotechnologies
ADPT
$4.15B
$33.4M 0.18%
1,115,411
-50,000
-4% -$1.44M
ALLK
37
DELISTED
Allakos
ALLK
$32.4M 0.17%
339,690
– –
ASMB icon
38
Assembly Biosciences
ASMB
$700M
$31.5M 0.17%
128,468
+61,531
+92% +$11.3M
KNSA icon
39
Kiniksa Pharmaceuticals
KNSA
$6.17B
$31M 0.16%
2,799,577
– –
CCXI
40
DELISTED
ChemoCentryx, Inc.
CCXI
$29.2M 0.16%
739,016
+531,987
+257% +$9.34M
MRUS
41
DELISTED
Merus
MRUS
$28.7M 0.15%
2,037,469
+877,455
+76% +$14.1M
URGN icon
42
UroGen Pharma
URGN
$2.29B
$27.7M 0.15%
831,488
+83,737
+11% +$2.29M
AIMT
43
DELISTED
Aimmune Therapeutics
AIMT
$22.6M 0.12%
673,908
– –
KRRO icon
44
Korro Bio
KRRO
$194M
$21.6M 0.11%
+24,629
New +$19.2M
ALKS icon
45
Alkermes
ALKS
$8.11B
$16.2M 0.09%
793,130
+168,100
+27% +$3.34M
UROV
46
DELISTED
Urovant Sciences Ltd.
UROV
$15.5M 0.08%
+1,000,000
New +$10.8M
APLS
47
DELISTED
Apellis Pharmaceuticals
APLS
$15.2M 0.08%
496,969
+183,244
+58% +$5.07M
XNCR icon
48
Xencor
XNCR
$2.07B
$14.7M 0.08%
428,120
– –
SYRE icon
49
Spyre Therapeutics
SYRE
$9.39B
$13.1M 0.07%
68,544
– –
HOOK
50
DELISTED
HOOKIPA Pharma
HOOK
$10.9M 0.06%
89,286
– –
1
2
3 4 5

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Julian Baker's Q4 2019 Portfolio in Review

As of Q4 2019, Julian Baker held 117 positions worth $18.8B, up 28% from $14.7B the previous quarter. Its ten largest holdings account for 85% of the portfolio.

Julian Baker's Q4 2019 filing shows 8 new, 21 increased, 10 reduced and 18 closed positions. Its largest new stake was Exact Sciences: 2,585,791 shares worth $239M. The largest sale was Genomic Health, Inc., an estimated $627M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials and Technology.

  • Julian Baker's largest Q4 2019 buy was Exact Sciences: 2,585,791 shares worth $239M.
  • Julian Baker added most to DBV Technologies in Q4 2019, an estimated $72.8M increase.
  • Julian Baker's biggest Q4 2019 reduction was Amarin Corp, cutting an estimated $134M.
  • Julian Baker fully exited Genomic Health, Inc. in Q4 2019, selling an estimated $627M.
  • Julian Baker's ten largest holdings make up 85% of its $18.8B portfolio in Q4 2019.
  • Julian Baker opened 8 new positions and closed 18 in Q4 2019.
  • Julian Baker's portfolio value rose 28% quarter-over-quarter to $18.8B.

Based on Baker Bros. Advisors's 13F filing for Q4 2019, filed 14 Feb 2020.