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Ishara Investments Portfolio holdings

AUM $136M
This Fund
S&P 500
This Quarter Est. Return
+85.41%
1 Year Est. Return
–
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$87.5M
AUM Growth
–
Cap. Flow
+$79.8M
Cap. Flow %
91.21%
Top 10 Hldgs %
55.95%
Holding
38
New
38
Increased
–
Reduced
–
Closed
–

Top Buys

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$7.45M
2
XERS icon
Xeris Biopharma Holdings
XERS
+$6.3M
3
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$5.44M
4
ACAD icon
Acadia Pharmaceuticals
ACAD
+$3.82M
5
FOLD
Amicus Therapeutics
FOLD
+$3.54M

Top Sells

No sells this quarter

Sector Composition

Rank Sector Weight
1 Healthcare 96.09%
2 Industrials 2.16%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
DNLI icon
26
Denali Therapeutics
DNLI
$3.89B
$1.16M 1.32%
+70,000
New +$1.18M
RARE icon
27
Ultragenyx Pharmaceutical
RARE
$2.58B
$1.15M 1.32%
+50,000
New +$1.64M
ASND icon
28
Ascendis Pharma A/S
ASND
$16.5B
$1.07M 1.22%
+5,000
New +$1.03M
NAMS icon
29
NewAmsterdam Pharma
NAMS
$3.23B
$1.05M 1.2%
+30,000
New +$1.09M
LXRX icon
30
Lexicon Pharmaceuticals
LXRX
$1.02B
$1.01M 1.16%
+880,000
New +$1.21M
BHVN icon
31
Biohaven
BHVN
$2.3B
$994K 1.14%
+88,000
New +$1.09M
DNTH icon
32
Dianthus Therapeutics
DNTH
$6.17B
$989K 1.13%
+24,000
New +$930K
NKTR icon
33
Nektar Therapeutics
NKTR
$2.52B
$846K 0.97%
+20,000
New +$1.12M
IMTX icon
34
Immatics
IMTX
$1.25B
$840K 0.96%
+80,000
New +$807K
AGIO icon
35
Agios Pharmaceuticals
AGIO
$2.02B
$817K 0.93%
+30,000
New +$1.05M
IMVT icon
36
Immunovant
IMVT
$8.96B
$763K 0.87%
+30,000
New +$669K
OLMA icon
37
Olema Pharmaceuticals
OLMA
$941M
$750K 0.86%
+30,000
New +$534K
ARQT icon
38
Arcutis Biotherapeutics
ARQT
$3.15B
$348K 0.4%
+12,000
New +$307K
1
2

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Ishara Investments's Q4 2025 Portfolio in Review

Q4 2025 is the first quarter with a 13F filing on record for Ishara Investments, which disclosed 38 positions worth $87.5M. Its ten largest holdings account for 56% of the portfolio.

Its largest position is Praxis Precision Medicines: 40,000 shares worth $11.8M.

By sector, the portfolio is most concentrated in Healthcare at 96% of assets, followed by Industrials.

  • Ishara Investments's largest Q4 2025 buy was Praxis Precision Medicines: 40,000 shares worth $11.8M.
  • Ishara Investments's ten largest holdings make up 56% of its $87.5M portfolio in Q4 2025.
  • Ishara Investments disclosed 38 positions in Q4 2025, its first 13F filing on record.

Based on Ishara Investments's 13F filing for Q4 2025, filed 17 Feb 2026.