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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+10.63%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$251M
AUM Growth
+$48.7M
Cap. Flow
+$25.5M
Cap. Flow %
10.17%
Top 10 Hldgs %
97.11%
Holding
502
New
500
Increased
1
Reduced
–
Closed
1

Top Buys

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$15.6M
2
MSFT icon
Microsoft
MSFT
+$700K
3
NVDA icon
NVIDIA
NVDA
+$665K
4
AAPL icon
Apple
AAPL
+$653K
5
AMZN icon
Amazon
AMZN
+$403K

Top Sells

Rank Stock Value
1
BIOA
BioAge Labs
BIOA
+$428K

Sector Composition

Rank Sector Weight
1 Technology 1.55%
2 Financials 0.62%
3 Consumer Discretionary 0.47%
4 Communication Services 0.44%
5 Healthcare 0.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AMCR icon
351
Amcor
AMCR
$21.5B
$4.54K ﹤0.01%
+99
New +$4.57K
PHM icon
352
Pultegroup
PHM
$24.6B
$4.54K ﹤0.01%
+43
New +$4.33K
HUBB icon
353
Hubbell
HUBB
$27.1B
$4.49K ﹤0.01%
+11
New +$4.08K
DVN icon
354
Devon Energy
DVN
$49.3B
$4.49K ﹤0.01%
+141
New +$4.49K
PTC icon
355
PTC
PTC
$16.1B
$4.48K ﹤0.01%
+26
New +$4.19K
CMS icon
356
CMS Energy
CMS
$22B
$4.43K ﹤0.01%
+64
New +$4.56K
FE icon
357
FirstEnergy
FE
$27.2B
$4.43K ﹤0.01%
+110
New +$4.54K
LDOS icon
358
Leidos
LDOS
$17.6B
$4.42K ﹤0.01%
+28
New +$4.14K
EXPE icon
359
Expedia Group
EXPE
$39.1B
$4.39K ﹤0.01%
+26
New +$4.22K
EIX icon
360
Edison International
EIX
$26.7B
$4.28K ﹤0.01%
+83
New +$4.55K
DLTR icon
361
Dollar Tree
DLTR
$24.7B
$4.26K ﹤0.01%
+43
New +$3.71K
WSM icon
362
Williams-Sonoma
WSM
$28.9B
$4.25K ﹤0.01%
+26
New +$4.08K
GPN icon
363
Global Payments
GPN
$23.4B
$4.24K ﹤0.01%
+53
New +$4.19K
TPL icon
364
Texas Pacific Land
TPL
$23.6B
$4.23K ﹤0.01%
+12
New +$4.91K
CFG icon
365
Citizens Financial Group
CFG
$31.1B
$4.21K ﹤0.01%
+94
New +$3.7K
WAT icon
366
Waters Corp
WAT
$40.9B
$4.19K ﹤0.01%
+12
New +$4.13K
LUV icon
367
Southwest Airlines
LUV
$22B
$4.15K ﹤0.01%
+128
New +$3.86K
DGX icon
368
Quest Diagnostics
DGX
$26.2B
$4.13K ﹤0.01%
+23
New +$4K
MKC icon
369
McCormick & Company Non-Voting
MKC
$14.2B
$4.09K ﹤0.01%
+54
New +$4.05K
NI icon
370
NiSource
NI
$20.1B
$4.07K ﹤0.01%
+101
New +$3.96K
IFF icon
371
International Flavors & Fragrances
IFF
$21.4B
$4.04K ﹤0.01%
+55
New +$4.15K
EL icon
372
Estee Lauder
EL
$31.7B
$4.04K ﹤0.01%
+50
New +$3.22K
CTRA
373
DELISTED
Coterra Energy
CTRA
$4.04K ﹤0.01%
+159
New +$4.03K
INVH icon
374
Invitation Homes
INVH
$17.7B
$4.03K ﹤0.01%
+123
New +$4.13K
TRMB icon
375
Trimble
TRMB
$13.1B
$4.03K ﹤0.01%
+53
New +$3.56K
13 14
15
16 17

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ACM
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MCM
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MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q2 2025 Portfolio in Review

As of Q2 2025, Howard Hughes Medical Institute held 502 positions worth $251M, up 24% from $202M the previous quarter. Its ten largest holdings account for 97% of the portfolio.

Howard Hughes Medical Institute deployed $25.5M of net new capital in Q2 2025, opening 500 new positions and adding to 1 existing holding. Its largest new stake was Microsoft: 1,611 shares worth $801K.

By sector, the portfolio is most concentrated in Technology at 1.6% of assets, followed by Financials and Consumer Discretionary.

On the sell side, the most notable exit was BioAge Labs, an estimated $428K sold.

  • Howard Hughes Medical Institute's largest Q2 2025 buy was Microsoft: 1,611 shares worth $801K.
  • Howard Hughes Medical Institute added most to State Street SPDR S&P 500 ETF Trust in Q2 2025, an estimated $15.6M increase.
  • Howard Hughes Medical Institute fully exited BioAge Labs in Q2 2025, selling an estimated $428K.
  • Howard Hughes Medical Institute's ten largest holdings make up 97% of its $251M portfolio in Q2 2025.
  • Howard Hughes Medical Institute opened 500 new positions and closed 1 in Q2 2025.
  • Howard Hughes Medical Institute's portfolio value rose 24% quarter-over-quarter to $251M.

Based on Howard Hughes Medical Institute's 13F filing for Q2 2025, filed 14 Aug 2025.