Fred Alger Management’s Spark Therapeutics, Inc. Common Stock ONCE Stock Holding History

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2018 Q4	–	Sell	-17,500	Closed	-$955K	–	595
2018 Q3	$955K	Sell	17,500 -1,500	-8%	-$103K	﹤0.01%	325
2018 Q2	$1.57M	Hold	19,000	–	–	0.01%	295
2018 Q1	$1.26M	Sell	19,000 -2,000	-10%	-$115K	0.01%	320
2017 Q4	$1.08M	Sell	21,000 -12,277	-37%	-$882K	﹤0.01%	332
2017 Q3	$2.97M	Buy	33,277 +12,277	+58%	+$932K	0.01%	263
2017 Q2	$1.25M	Sell	21,000 -30,305	-59%	-$1.69M	0.01%	320
2017 Q1	$2.74M	Buy	51,305 +32,305	+170%	+$1.92M	0.01%	270
2016 Q4	$948K	Buy	19,000 +1,500	+9%	+$80.4K	0.01%	293
2016 Q3	$1.05M	Buy	17,500 +3,500	+25%	+$202K	0.01%	304
2016 Q2	$716K	Buy	14,000 +8,000	+133%	+$342K	﹤0.01%	353
2016 Q1	$177K	Buy	+6,000	New	+$189K	﹤0.01%	447
2015 Q4	–	Sell	-10,850	Closed	-$453K	–	608
2015 Q3	$453K	Sell	10,850 -2,000	-16%	-$104K	﹤0.01%	441
2015 Q2	$774K	Buy	12,850 +3,350	+35%	+$221K	﹤0.01%	439
2015 Q1	$736K	Buy	+9,500	New	+$547K	﹤0.01%	521