D.E. Shaw & Co Portfolio holdings
D. E. Shaw & Co., L.P., founded in 1988 by David E. Shaw, a former Columbia University computer science professor, is a New York City-based global investment management firm renowned for pioneering quantitative investing, managing over $70 billion in assets as of late 2024. Starting with $28 million from Paloma Partners and private investors, the firm employs sophisticated mathematical models and proprietary algorithms—initially developed by a team of scientists and programmers—to exploit market anomalies across public and private markets, including equities, fixed income, and alternatives. Headquartered above a Greenwich Village bookstore in its early days, it now boasts over 2,500 employees across offices in North America, Europe, and Asia, led by a seven-member Executive Committee since Shaw stepped back in 2001 to focus on D. E. Shaw Research. Despite setbacks like the 1998 Russia debt crisis and the 2008 financial downturn, the firm has maintained a reputation for analytical rigor, risk management, and innovation, balancing its computational roots with discretionary strategies.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
Advanced Micro Devices
AMD
|
+$1.52B |
| 2 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$1.43B |
| 3 |
iShares Core S&P 500 ETF
IVV
|
+$798M |
| 4 |
Amazon
AMZN
|
+$646M |
| 5 |
Texas Instruments
TXN
|
+$619M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Micron Technology
MU
|
+$1.31B |
| 2 |
Broadcom
AVGO
|
+$1.01B |
| 3 |
Vanguard Intermediate-Term Corporate Bond ETF
VCIT
|
+$863M |
| 4 |
Western Digital
WDC
|
+$595M |
| 5 |
Meta Platforms (Facebook)
META
|
+$591M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 18.6% |
| 2 | Consumer Discretionary | 9.12% |
| 3 | Healthcare | 7.62% |
| 4 | Industrials | 7.14% |
| 5 | Financials | 6.8% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
1676
BioCryst Pharmaceuticals
BCRX
$2.42B
| $9.73M | 0.01% |
1,247,466
-461,870
| -27% | -$3.34M |
|
|
DVAX
1677
DELISTED
Dynavax Technologies
DVAX
| $9.73M | 0.01% |
632,594
-443,753
| -41% | -$4.89M |
|
1678
Xerox
XRX
$348M
| $9.72M | 0.01% |
4,100,290
+2,699,134
| +193% | +$7.99M |
|
1679
Arrowhead Research
ARWR
$12.5B
| $9.7M | 0.01% |
146,064
+125,763
| +619% | +$6.16M |
|
1680
AutoZone
AZO
$48.5B
| $9.69M | 0.01% |
2,857
-389
| -12% | -$1.47M |
|
1681
Realty Income
O
$60.6B
| $9.67M | 0.01% |
171,480
-52,191
| -23% | -$3.02M |
|
1682
CALL
NIO
NIO
$11.7B
| $9.65M | 0.01% |
1,892,800
-1,247,700
| -40% | -$7.7M |
|
1683
Inhibrx
INBX
$1.26B
| $9.65M | 0.01% |
122,101
+110,548
| +957% | +$7.53M |
|
1684
Unisys
UIS
$248M
| $9.63M | 0.01% |
3,490,445
+406,187
| +13% | +$1.27M |
|
1685
Century Communities
CCS
$1.86B
| $9.63M | 0.01% |
162,313
+13,445
| +9% | +$818K |
|
1686
CALL
Novartis
NVS
$291B
| $9.6M | 0.01% |
+69,600
| New | +$9.11M |
|
|
DQ
1687
Daqo New Energy
DQ
$812M
| $9.59M | 0.01% |
325,128
+175,475
| +117% | +$5.36M |
|
1688
VanEck Uranium + Nuclear Energy ETF
NLR
$4.01B
| $9.59M | 0.01% |
+77,214
| New | +$10.6M |
|
1689
GFL Environmental
GFL
$14.1B
| $9.59M | 0.01% |
223,246
+122,195
| +121% | +$5.46M |
|
1690
CALL
Duolingo
DUOL
$5.57B
| $9.58M | 0.01% |
54,600
-45,400
| -45% | -$10.7M |
|
1691
The Ensign Group
ENSG
$9.88B
| $9.58M | 0.01% |
55,005
+52,141
| +1,821% | +$9.37M |
|
|
HUT
1692
CALL
Hut 8
HUT
$12.4B
| $9.58M | 0.01% |
208,500
+151,900
| +268% | +$6.7M |
|
1693
CALL
Cenovus Energy
CVE
$54.1B
| $9.57M | 0.01% |
565,700
-409,600
| -42% | -$7.11M |
|
1694
Agnico Eagle Mines
AEM
$73.5B
| $9.53M | 0.01% |
56,238
-43,352
| -44% | -$7.29M |
|
1695
Phinia Inc
PHIN
$2.95B
| $9.51M | 0.01% |
151,741
-18,839
| -11% | -$1.04M |
|
1696
PUT
Tyson Foods
TSN
$20.1B
| $9.49M | 0.01% |
161,900
+89,900
| +125% | +$4.94M |
|
1697
Amgen
AMGN
$198B
| $9.48M | 0.01% |
28,977
-99,882
| -78% | -$31.7M |
|
1698
CALL
Oscar Health
OSCR
$8.89B
| $9.48M | 0.01% |
660,000
-149,300
| -18% | -$2.58M |
|
1699
McCormick & Company Non-Voting
MKC
$14B
| $9.48M | 0.01% |
139,231
-264,917
| -66% | -$17.6M |
|
1700
CALL
Kroger
KR
$35.3B
| $9.48M | 0.01% |
151,700
| – | – |
|
Similar funds
D.E. Shaw & Co's Q4 2025 Portfolio in Review
As of Q4 2025, D.E. Shaw & Co held 5,141 positions worth $182B, up 3% from $177B the previous quarter. Its ten largest holdings account for 12% of the portfolio.
D.E. Shaw & Co's Q4 2025 filing shows 639 new, 1,734 increased, 1,574 reduced and 583 closed positions. Its largest new stake was iShares Core S&P 500 ETF: 1,175,000 shares worth $805M. The largest sale was Micron Technology, an estimated $1.31B.
By sector, the portfolio is most concentrated in Technology at 19% of assets, down from 19% a quarter earlier, followed by Consumer Discretionary and Healthcare.
- D.E. Shaw & Co's largest Q4 2025 buy was iShares Core S&P 500 ETF: 1,175,000 shares worth $805M.
- D.E. Shaw & Co added most to Advanced Micro Devices in Q4 2025, an estimated $1.52B increase.
- D.E. Shaw & Co's biggest Q4 2025 reduction was Micron Technology, cutting an estimated $1.31B.
- D.E. Shaw & Co fully exited Vanguard Short-Term Corporate Bond ETF in Q4 2025, selling an estimated $499M.
- D.E. Shaw & Co's ten largest holdings make up 12% of its $182B portfolio in Q4 2025.
- D.E. Shaw & Co opened 639 new positions and closed 583 in Q4 2025.
- D.E. Shaw & Co's portfolio value rose 3% quarter-over-quarter to $182B.
Based on D.E. Shaw & Co's 13F filing for Q4 2025, filed 17 Feb 2026.