D.E. Shaw & Co Portfolio holdings
D. E. Shaw & Co., L.P., founded in 1988 by David E. Shaw, a former Columbia University computer science professor, is a New York City-based global investment management firm renowned for pioneering quantitative investing, managing over $70 billion in assets as of late 2024. Starting with $28 million from Paloma Partners and private investors, the firm employs sophisticated mathematical models and proprietary algorithms—initially developed by a team of scientists and programmers—to exploit market anomalies across public and private markets, including equities, fixed income, and alternatives. Headquartered above a Greenwich Village bookstore in its early days, it now boasts over 2,500 employees across offices in North America, Europe, and Asia, led by a seven-member Executive Committee since Shaw stepped back in 2001 to focus on D. E. Shaw Research. Despite setbacks like the 1998 Russia debt crisis and the 2008 financial downturn, the firm has maintained a reputation for analytical rigor, risk management, and innovation, balancing its computational roots with discretionary strategies.
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
Advanced Micro Devices
AMD
|
+$1.52B |
| 2 |
State Street SPDR S&P 500 ETF Trust
SPY
|
+$1.43B |
| 3 |
iShares Core S&P 500 ETF
IVV
|
+$798M |
| 4 |
Amazon
AMZN
|
+$646M |
| 5 |
Texas Instruments
TXN
|
+$619M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Micron Technology
MU
|
+$1.31B |
| 2 |
Broadcom
AVGO
|
+$1.01B |
| 3 |
Vanguard Intermediate-Term Corporate Bond ETF
VCIT
|
+$863M |
| 4 |
Western Digital
WDC
|
+$595M |
| 5 |
Meta Platforms (Facebook)
META
|
+$591M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Technology | 18.6% |
| 2 | Consumer Discretionary | 9.12% |
| 3 | Healthcare | 7.62% |
| 4 | Industrials | 7.14% |
| 5 | Financials | 6.8% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
3601
Erasca
ERAS
$6.65B
| $751K | ﹤0.01% |
+201,938
| New | +$568K |
|
3602
iShares MSCI Brazil Small-Cap ETF
EWZS
$233M
| $748K | ﹤0.01% |
57,830
-25,816
| -31% | -$348K |
|
3603
Seer Inc
SEER
$119M
| $748K | ﹤0.01% |
408,557
-182,960
| -31% | -$373K |
|
3604
CALL
Intellia Therapeutics
NTLA
$1.59B
| $747K | ﹤0.01% |
+83,100
| New | +$1.14M |
|
3605
CALL
Descartes Systems
DSGX
$6.35B
| $745K | ﹤0.01% |
8,500
+3,500
| +70% | +$313K |
|
3606
BlackLine
BL
$1.78B
| $743K | ﹤0.01% |
13,445
-4,543
| -25% | -$250K |
|
|
OPENL
3607
Opendoor Technologies Inc Series A Warrants
OPENL
$7.62M
| $743K | ﹤0.01% |
+1,428,549
| New | +$1.22M |
|
3608
Triple Flag Precious Metals
TFPM
$5.65B
| $741K | ﹤0.01% |
22,300
-60,366
| -73% | -$1.89M |
|
|
GAP
3609
CALL
The Gap Inc
GAP
$7.33B
| $737K | ﹤0.01% |
28,800
| – | – |
|
|
ALIS
3610
Calisa Acquisition Corp
ALIS
$85.6M
| $737K | ﹤0.01% |
+74,200
| New | +$735K |
|
3611
Vanguard Financials ETF
VFH
$13.4B
| $736K | ﹤0.01% |
+5,517
| New | +$717K |
|
|
UNIT
3612
CALL
Uniti Group
UNIT
$2.68B
| $736K | ﹤0.01% |
105,000
| – | – |
|
|
UPB
3613
Upstream Bio Inc
UPB
$381M
| $736K | ﹤0.01% |
+27,091
| New | +$674K |
|
|
MCHB
3614
Mechanics Bancorp
MCHB
$3.6B
| $735K | ﹤0.01% |
50,272
-390,943
| -89% | -$5.43M |
|
|
TLN
3615
Talen Energy Corp
TLN
$17.8B
| $735K | ﹤0.01% |
1,960
-934
| -32% | -$363K |
|
3616
Janus International
JBI
$737M
| $731K | ﹤0.01% |
111,779
+24,666
| +28% | +$192K |
|
3617
PUT
Ramaco Resources Class A
METC
$762M
| $731K | ﹤0.01% |
40,600
+33,400
| +464% | +$878K |
|
3618
Domo
DOMO
$157M
| $731K | ﹤0.01% |
86,689
-11,551
| -12% | -$136K |
|
|
ONC
3619
PUT
BeOne Medicines Ltd
ONC
$32.4B
| $729K | ﹤0.01% |
+2,400
| New | +$786K |
|
3620
Revvity
RVTY
$12.3B
| $728K | ﹤0.01% |
+7,528
| New | +$723K |
|
3621
Solid Biosciences
SLDB
$858M
| $723K | ﹤0.01% |
+128,260
| New | +$695K |
|
3622
CALL
Green Plains
GPRE
$1.35B
| $722K | ﹤0.01% |
73,700
| – | – |
|
3623
Tejon Ranch
TRC
$491M
| $717K | ﹤0.01% |
45,448
-15,602
| -26% | -$249K |
|
3624
PUT
Alnylam Pharmaceuticals
ALNY
$35.7B
| $716K | ﹤0.01% |
1,800
+900
| +100% | +$398K |
|
3625
PUT
Perion Network
PERI
$369M
| $716K | ﹤0.01% |
74,700
| – | – |
|
Similar funds
D.E. Shaw & Co's Q4 2025 Portfolio in Review
As of Q4 2025, D.E. Shaw & Co held 5,141 positions worth $182B, up 3% from $177B the previous quarter. Its ten largest holdings account for 12% of the portfolio.
D.E. Shaw & Co's Q4 2025 filing shows 639 new, 1,734 increased, 1,574 reduced and 583 closed positions. Its largest new stake was iShares Core S&P 500 ETF: 1,175,000 shares worth $805M. The largest sale was Micron Technology, an estimated $1.31B.
By sector, the portfolio is most concentrated in Technology at 19% of assets, down from 19% a quarter earlier, followed by Consumer Discretionary and Healthcare.
- D.E. Shaw & Co's largest Q4 2025 buy was iShares Core S&P 500 ETF: 1,175,000 shares worth $805M.
- D.E. Shaw & Co added most to Advanced Micro Devices in Q4 2025, an estimated $1.52B increase.
- D.E. Shaw & Co's biggest Q4 2025 reduction was Micron Technology, cutting an estimated $1.31B.
- D.E. Shaw & Co fully exited Vanguard Short-Term Corporate Bond ETF in Q4 2025, selling an estimated $499M.
- D.E. Shaw & Co's ten largest holdings make up 12% of its $182B portfolio in Q4 2025.
- D.E. Shaw & Co opened 639 new positions and closed 583 in Q4 2025.
- D.E. Shaw & Co's portfolio value rose 3% quarter-over-quarter to $182B.
Based on D.E. Shaw & Co's 13F filing for Q4 2025, filed 17 Feb 2026.