D.E. Shaw & Co’s Nuvalent NUVL Stock Holding History

D.E. Shaw & Co’s Portfolio NUVL Stock Details NUVL Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2024 Q1	–	Sell	-10,000	Closed	-$736K	–	4610
2023 Q4	$736K	Buy	+10,000	New	+$619K	﹤0.01%	3332

Other funds holding NUVL

Deerfield Management New York $8.48B AUM 99.04% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

PBA

Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return

JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return

RCM

RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

D.E. Shaw & Co's NUVL Position: Q4 2025 in Review

D.E. Shaw & Co sold out of Nuvalent (NUVL) in Q4 2025, closing a stake of 27,311 shares — an estimated $2.36M sold.

D.E. Shaw & Co first reported a position in NUVL in Q3 2021 and held it in 15 quarters. The position peaked at $34.5M in Q4 2023. 237 funds tracked by Wall St. Rank hold NUVL as of Q4 2025.

D.E. Shaw & Co reported no remaining Nuvalent position as of Q4 2025 after selling out during the quarter.
D.E. Shaw & Co sold 27,311 Nuvalent shares in Q4 2025, an estimated $2.36M.
D.E. Shaw & Co first reported a position in Nuvalent in Q3 2021 and held it in 15 quarters.
D.E. Shaw & Co's Nuvalent position peaked at $34.5M in Q4 2023.
237 funds tracked by Wall St. Rank held Nuvalent as of Q4 2025.

Based on D.E. Shaw & Co's 13F filing for Q4 2025, filed 17 Feb 2026.