Brandywine Global Investment Management’s Puma Biotechnology PBYI Stock Holding History

Brandywine Global Investment Management’s Portfolio PBYI Stock Details PBYI Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	$130K	Buy	+21,800	New	+$116K	﹤0.01%	594
2024 Q3	–	Sell	-32,210	Closed	-$105K	–	716
2024 Q2	$105K	Buy	+32,210	New	+$141K	﹤0.01%	677
2023 Q1	–	Sell	-318,601	Closed	-$1.35M	–	744
2022 Q4	$1.35M	Hold	318,601	–	–	0.01%	616
2022 Q3	$755K	Sell	318,601 -11,899	-4%	-$34.7K	0.01%	649
2022 Q2	$942K	Sell	330,500 -49,500	-13%	-$123K	0.01%	615
2022 Q1	$1.09M	Hold	380,000	–	–	0.01%	615
2021 Q4	$1.16M	Buy	+380,000	New	+$1.65M	0.01%	574

Other funds holding PBYI

ACA

Acorn Capital Advisors New York $366M AUM 474.6% 1-Year Est. Return

Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Renaissance Technologies New York $72.6B AUM 54.88% 1-Year Est. Return

Acadian Asset Management Boston, Massachusetts $84.2B AUM 55.88% 1-Year Est. Return

American Century Companies Kansas City, Missouri $226B AUM 44.75% 1-Year Est. Return

Dimensional Fund Advisors Austin, Texas $552B AUM 44.19% 1-Year Est. Return

OSAM

O'Shaughnessy Asset Management Stamford, Connecticut $21.7B AUM 41.93% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

Brandywine Global Investment Management's PBYI Position: Q4 2025 in Review

Brandywine Global Investment Management opened a new position in Puma Biotechnology (PBYI) in Q4 2025: 21,800 shares worth $130K. The stake represents ﹤0.01% of the portfolio and ranks #594 among its holdings. This is a return to the name: Brandywine Global Investment Management previously reported a position in PBYI as recently as Q2 2024.

Brandywine Global Investment Management first reported a position in PBYI in Q4 2021 and has held it in 7 quarters since. The position peaked at $1.35M in Q4 2022. 151 funds tracked by Wall St. Rank hold PBYI as of Q4 2025.

Brandywine Global Investment Management held 21,800 shares of Puma Biotechnology worth $130K as of Q4 2025.
Puma Biotechnology was a new Brandywine Global Investment Management position in Q4 2025.
Puma Biotechnology made up ﹤0.01% of Brandywine Global Investment Management's portfolio in Q4 2025, its #594 holding.
Brandywine Global Investment Management first reported a position in Puma Biotechnology in Q4 2021 and has held it in 7 quarters since.
Brandywine Global Investment Management's Puma Biotechnology position peaked at $1.35M in Q4 2022.
151 funds tracked by Wall St. Rank held Puma Biotechnology as of Q4 2025.

Based on Brandywine Global Investment Management's 13F filing for Q4 2025, filed 11 Feb 2026.