Baker Bros. Advisors’s Sierra Oncology, Inc. Common Stock SRRA Stock Holding History

Quarter	Market Value	Status	Shares	Shares Change %	Trade Value	Portfolio Weight	Portfolio Position
2019 Q4	–	Sell	-2,000,000	Closed	-$781K	–	108
2019 Q3	$781K	Hold	2,000,000	–	–	0.01%	101
2019 Q2	$1.12M	Hold	2,000,000	–	–	0.01%	93
2019 Q1	$3.42M	Hold	2,000,000	–	–	0.02%	67
2018 Q4	$2.64M	Buy	+2,000,000	New	+$2.64M	0.02%	67
2017 Q1	–	Sell	-200,000	Closed	-$298K	–	133
2016 Q4	$298K	Hold	200,000	–	–	﹤0.01%	129
2016 Q3	$364K	Hold	200,000	–	–	﹤0.01%	130
2016 Q2	$398K	Hold	200,000	–	–	﹤0.01%	129
2016 Q1	$1.35M	Hold	200,000	–	–	0.01%	111
2015 Q4	$3.01M	Hold	200,000	–	–	0.02%	92
2015 Q3	$4.1M	Buy	+200,000	New	+$4.1M	0.04%	82