Baker Bros. Advisors’s Adamas Pharmaceuticals, Inc. ADMS Stock Holding History

Quarter	Market Value	Status	Shares	Shares Change %	Trade Value	Portfolio Weight	Portfolio Position
2021 Q2	–	Sell	-147,996	Closed	-$710K	–	133
2021 Q1	$710K	Hold	147,996	–	–	﹤0.01%	122
2020 Q4	$641K	Sell	147,996 -15,834	-10%	-$68.6K	﹤0.01%	122
2020 Q3	$675K	Sell	163,830 -8,800	-5%	-$36.3K	﹤0.01%	116
2020 Q2	$442K	Hold	172,630	–	–	﹤0.01%	111
2020 Q1	$499K	Hold	172,630	–	–	﹤0.01%	104
2019 Q4	$654K	Hold	172,630	–	–	﹤0.01%	95
2019 Q3	$883K	Hold	172,630	–	–	0.01%	99
2019 Q2	$1.07M	Hold	172,630	–	–	0.01%	94
2019 Q1	$1.23M	Hold	172,630	–	–	0.01%	87
2018 Q4	$1.47M	Hold	172,630	–	–	0.01%	78
2018 Q3	$3.46M	Hold	172,630	–	–	0.02%	80
2018 Q2	$4.46M	Hold	172,630	–	–	0.03%	81
2018 Q1	$4.13M	Hold	172,630	–	–	0.04%	82
2017 Q4	$5.85M	Hold	172,630	–	–	0.05%	73
2017 Q3	$3.66M	Hold	172,630	–	–	0.03%	84
2017 Q2	$3.02M	Hold	172,630	–	–	0.03%	74
2017 Q1	$3.02M	Hold	172,630	–	–	0.02%	78
2016 Q4	$2.92M	Hold	172,630	–	–	0.03%	79
2016 Q3	$2.83M	Hold	172,630	–	–	0.03%	82
2016 Q2	$2.61M	Hold	172,630	–	–	0.03%	87
2016 Q1	$2.5M	Buy	+172,630	New	+$2.5M	0.03%	92