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APM

Avidity Partners Management Portfolio holdings

AUM $936M
1-Year Est. Return 195%
This Fund
S&P 500
This Quarter Est. Return
+25.49%
1 Year Est. Return
+195%
3 Year Est. Return
+460.87%
5 Year Est. Return
+815.5%
10 Year Est. Return
–
AUM
$4.62B
AUM Growth
-$303M
Cap. Flow
-$719M
Cap. Flow %
-15.57%
Top 10 Hldgs %
43.33%
Holding
116
New
19
Increased
32
Reduced
19
Closed
31

Top Buys

Rank Stock Value
1
UHS icon
Universal Health Services
UHS
+$97.5M
2
SGRY icon
Surgery Partners
SGRY
+$75.3M
3
JAZZ icon
Jazz Pharmaceuticals
JAZZ
+$60M
4
PRTA icon
Prothena Corp
PRTA
+$57.7M
5
ARGX icon
argenx
ARGX
+$49.8M

Top Sells

Rank Stock Value
1
LLY icon
Eli Lilly
LLY
+$280M
2
BIIB icon
Biogen
BIIB
+$160M
3
XBI icon
State Street SPDR S&P Biotech ETF
XBI
+$120M
4
VRTX icon
Vertex Pharmaceuticals
VRTX
+$104M
5
HUM icon
Humana
HUM
+$103M

Sector Composition

Rank Sector Weight
1 Healthcare 92.28%
2 Financials 0.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SYK icon
101
Stryker
SYK
$134B
– –
-184,700
Closed -$37.4M
TMDX icon
102
Transmedics
TMDX
$2.6B
– –
-300,000
Closed -$12.5M
TNGX icon
103
Tango Therapeutics
TNGX
$4.23B
– –
-813,700
Closed -$2.95M
WGS icon
104
GeneDx Holdings
WGS
$1.86B
– –
-28,788
Closed -$834K
XBI icon
105
State Street SPDR S&P Biotech ETF
XBI
$10B
– –
-1,480,000
Closed -$120M
XNTK icon
106
CALL
State Street SPDR NYSE Technology ETF
XNTK
$1.96B
– –
-4,052,000
Closed -$321M
ONC
107
BeOne Medicines Ltd
ONC
$33.9B
– –
-132,000
Closed -$17.8M
CTLT
108
DELISTED
CATALENT, INC.
CTLT
– –
-940,000
Closed -$68M
NGM
109
DELISTED
NGM Biopharmaceuticals, Inc. Common Stock
NGM
– –
-1,798,100
Closed -$23.5M
SNCE
110
DELISTED
Science 37 Holdings, Inc. Common Stock
SNCE
– –
-21,500
Closed -$692K
SGEN
111
DELISTED
Seagen Inc. Common Stock
SGEN
– –
-445,500
Closed -$61M
SPNE
112
DELISTED
SeaSpine Holdings Corporation Common Stock
SPNE
– –
-2,010,000
Closed -$11.4M
PHAS
113
DELISTED
PhaseBio Pharmaceuticals, Inc. Common Stock
PHAS
– –
-4,361,365
Closed -$768K
BLSA
114
DELISTED
BCLS Acquisition Corp. Class A Ordinary Shares
BLSA
– –
-500,000
Closed -$5.01M
ONCS
115
DELISTED
OncoSec Medical Incorporated
ONCS
– –
-133,864
Closed -$1.44M
HZNP
116
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
– –
-1,482,200
Closed -$91.7M
1 2 3 4
5

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Avidity Partners Management's Q4 2022 Portfolio in Review

As of Q4 2022, Avidity Partners Management held 116 positions worth $4.62B, down 6.2% from $4.92B the previous quarter. Its ten largest holdings account for 43% of the portfolio.

Avidity Partners Management withdrew a net $719M in Q4 2022, closing 31 positions and reducing 19 holdings. Its most notable exit was Biogen, an estimated $160M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 92% of assets, up from 90% a quarter earlier, followed by Financials.

Against the trend, Avidity Partners Management opened a new position in Universal Health Services worth $116M.

  • Avidity Partners Management's largest Q4 2022 buy was Universal Health Services: 825,600 shares worth $116M.
  • Avidity Partners Management added most to Surgery Partners in Q4 2022, an estimated $75.3M increase.
  • Avidity Partners Management's biggest Q4 2022 reduction was Eli Lilly, cutting an estimated $280M.
  • Avidity Partners Management fully exited Biogen in Q4 2022, selling an estimated $160M.
  • Avidity Partners Management's ten largest holdings make up 43% of its $4.62B portfolio in Q4 2022.
  • Avidity Partners Management opened 19 new positions and closed 31 in Q4 2022.
  • Avidity Partners Management's portfolio value fell 6.2% quarter-over-quarter to $4.62B.

Based on Avidity Partners Management's 13F filing for Q4 2022, filed 14 Feb 2023.