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AVLSA

Atlas Venture Life Science Advisors Portfolio holdings

AUM $790M
1-Year Est. Return 223.66%
This Fund
S&P 500
This Quarter Est. Return
+52.07%
1 Year Est. Return
+223.66%
3 Year Est. Return
+485.32%
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$753M
AUM Growth
+$90.3M
Cap. Flow
-$120M
Cap. Flow %
-15.88%
Top 10 Hldgs %
100%
Holding
11
New
–
Increased
–
Reduced
4
Closed
2

Top Buys

No buys this quarter

Top Sells

Rank Stock Value
1
THRD
Third Harmonic Bio
THRD
+$56.5M
2
VIGL
Vigil Neuroscience
VIGL
+$46.4M
3
IRON icon
Disc Medicine
IRON
+$14.4M
4
SION
Sionna Therapeutics
SION
+$1.71M
5
IMA
ImageneBio Inc
IMA
+$535K

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
KYMR icon
1
Kymera Therapeutics
KYMR
$8.32B
$277M 36.82%
4,896,462
– –
IRON icon
2
Disc Medicine
IRON
$2.96B
$142M 18.81%
2,142,617
-241,839
-10% -$14.4M
DYN icon
3
Dyne Therapeutics
DYN
$4.69B
$116M 15.35%
9,130,465
– –
SION
4
Sionna Therapeutics
SION
$2.14B
$106M 14.13%
3,615,527
-78,493
-2% -$1.71M
KRRO icon
5
Korro Bio
KRRO
$156M
$54.5M 7.24%
1,137,149
– –
DAWN
6
DELISTED
Day One Biopharmaceuticals
DAWN
$45.3M 6.02%
6,430,257
– –
GBIO
7
DELISTED
Generation Bio
GBIO
$5.07M 0.67%
827,946
-2
-0% -$10
QTTB icon
8
Q32 Bio
QTTB
$464M
$4.14M 0.55%
2,092,106
– –
IMA
9
ImageneBio Inc
IMA
$63M
$3.08M 0.41%
377,814
-40,368
-10% -$535K
THRD
10
DELISTED
Third Harmonic Bio
THRD
– –
-10,402,286
Closed -$56.5M
VIGL
11
DELISTED
Vigil Neuroscience
VIGL
– –
-5,836,874
Closed -$46.4M

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Atlas Venture Life Science Advisors's Q3 2025 Portfolio in Review

As of Q3 2025, Atlas Venture Life Science Advisors held 11 positions worth $753M, up 14% from $662M the previous quarter. Its ten largest holdings account for 100% of the portfolio.

Atlas Venture Life Science Advisors withdrew a net $120M in Q3 2025, closing 2 positions and reducing 4 holdings. Its most notable exit was Third Harmonic Bio, an estimated $56.5M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, unchanged from a quarter earlier.

  • Atlas Venture Life Science Advisors's biggest Q3 2025 reduction was Disc Medicine, cutting an estimated $14.4M.
  • Atlas Venture Life Science Advisors fully exited Third Harmonic Bio in Q3 2025, selling an estimated $56.5M.
  • Atlas Venture Life Science Advisors's ten largest holdings make up 100% of its $753M portfolio in Q3 2025.
  • Atlas Venture Life Science Advisors opened 0 new positions and closed 2 in Q3 2025.
  • Atlas Venture Life Science Advisors's portfolio value rose 14% quarter-over-quarter to $753M.

Based on Atlas Venture Life Science Advisors's 13F filing for Q3 2025, filed 13 Nov 2025.