|
26
|
Bank of New York Mellon
New York
|
$715M
|
+$89.8M
|
60
|
0.15%
|
Increased
|
|
|
27
|
Capital International Investors
Los Angeles,
California
|
$627M
|
-$52.2M
|
6
|
0.15%
|
Reduced
|
|
|
28
|
|
$604M
|
+$60M
|
22
|
0.12%
|
Increased
|
|
|
29
|
RA Capital Management
Boston,
Massachusetts
|
$559M
|
+$287M
|
5
|
10.55%
|
Increased
|
|
|
30
|
|
$557M
|
-$14.4M
|
43
|
0.15%
|
Reduced
|
|
|
31
|
Viking Global Investors
Stamford,
Connecticut
|
$544M
|
-$201M
|
2
|
2.23%
|
Reduced
|
|
|
32
|
Kohlberg Kravis Roberts & Co
New York
|
$534M
|
$0
|
1
|
16.54%
|
Maintained
|
|
|
33
|
Redmile Group
San Francisco,
California
|
$530M
|
-$30.8M
|
11
|
20.35%
|
Reduced
|
|
|
34
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$525M
|
-$59.5M
|
30
|
1.3%
|
Reduced
|
|
|
35
|
HHLR Advisors
Grand Cayman,
Cayman Islands
|
$496M
|
+$56.8M
|
2
|
10.56%
|
Increased
|
|
|
36
|
ClearBridge Investments
New York
|
$496M
|
+$71.1M
|
3
|
0.45%
|
Increased
|
|
|
37
|
|
$477M
|
+$17M
|
11
|
41.69%
|
Increased
|
|
|
38
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$477M
|
+$144M
|
49
|
0.25%
|
Increased
|
|
|
39
|
AllianceBernstein
Nashville,
Tennessee
|
$439M
|
-$92.6M
|
40
|
0.18%
|
Reduced
|
|
|
40
|
Sumitomo Mitsui Trust Group
Minato-Ku, Tokyo,
Japan
|
$437M
|
+$9.73M
|
7
|
0.34%
|
Increased
|
|
|
41
|
Citadel Advisors
Miami,
Florida
|
$406M
|
+$12.6M
|
66
|
0.08%
|
Increased
|
|
|
42
|
Renaissance Technologies
New York
|
$402M
|
-$108M
|
68
|
0.58%
|
Reduced
|
|
|
43
|
Millennium Management
New York
|
$399M
|
-$178M
|
59
|
0.2%
|
Reduced
|
|
|
44
|
Wells Fargo
San Francisco,
California
|
$398M
|
+$10.2M
|
91
|
0.11%
|
Increased
|
|
|
45
|
Nomura Holdings
Tokyo,
Japan
|
$382M
|
+$352M
|
4
|
1.03%
|
Increased
|
|
|
46
|
Nikko Asset Management Americas
New York
|
$381M
|
+$15.4M
|
3
|
4.02%
|
Increased
|
|
|
47
|
Pictet Asset Management (Switzerland)
Geneva 73,
Switzerland
|
$377M
|
-$97.5M
|
18
|
0.45%
|
Reduced
|
|
|
48
|
Point72 Asset Management
Stamford,
Connecticut
|
$364M
|
-$143M
|
28
|
1.08%
|
Reduced
|
|
|
49
|
Adage Capital Partners
Boston,
Massachusetts
|
$362M
|
+$69.2M
|
16
|
0.79%
|
Increased
|
|
|
50
|
Kayne Anderson Rudnick Investment Management
Los Angeles,
California
|
$355M
|
+$10.5M
|
4
|
1%
|
Increased
|
|