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Xeris Biopharma Holdings
XERS

230 hedge funds and large institutions have $789M invested in Xeris Biopharma Holdings in 2025 Q3 according to their latest regulatory filings, with 59 funds opening new positions, 77 increasing their positions, 61 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

396% more call options, than puts

Call options by funds: $3.88M | Put options by funds: $782K

111% more first-time investments, than exits

New positions opened: 59 | Existing positions closed: 28

87% more capital invested

Capital invested by funds: $422M → $789M (+$366M)

26% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 61

15% more funds holding

Funds holding: 200 → 230 (+30)

2.14% more ownership

Funds ownership: 57.85% → 59.99% (+2.1%)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

Holders
230
Holders Change
+30
Holders Change %
+15%
% of All Funds
3.02%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
59
Increased
77
Reduced
61
Closed
28
Calls
$3.88M
Puts
$782K
Net Calls
+$3.1M
Net Calls Change
+$2.46M

Top Buyers

Rank Fund Capital Flow
1
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$13.3M
2
UBS Group
UBS Group
Switzerland
+$10.3M
3
Jane Street
Jane Street
New York
+$5.86M
4
Charles Schwab
Charles Schwab
California
+$5.84M
5
Deutsche Bank
Deutsche Bank
Germany
+$5.52M

Top Sellers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
-$16M
2
CP
CenterBook Partners
Connecticut
-$5.95M
3
CSS
Cubist Systematic Strategies
Connecticut
-$4.11M
4
Goldman Sachs
Goldman Sachs
New York
-$3.16M
5
Legal & General Group
Legal & General Group
United Kingdom
-$2.97M
Name Holding Trade Value Shares
Change 		Change in
Stake
SS
226
Sunbelt Securities
Texas
$659 +$538 +81 New
CIAM
227
Caitong International Asset Management
Hong Kong
$651 -$8.34K -1,256 -94%
SGK
228
Steigerwald Gordon & Koch
Virginia
$301 +$246 +37 New
GI
229
GAMMA Investing
California
$195 +$159 +24 New
IA
230
IFP Advisors
Florida
$163 -$399 -60 -75%
CSS
231
Cubist Systematic Strategies
Connecticut
– -$4.11M -880,314 Closed
Norges Bank
232
Norges Bank
Norway
– -$2.62M -561,700 Closed
VC
233
Voss Capital
Texas
– -$1.49M -319,800 Closed
SCM
234
Stonepine Capital Management
Oregon
– -$958K -205,100 Closed
Jacobs Levy Equity Management
235
Jacobs Levy Equity Management
New Jersey
– -$849K -181,877 Closed
AGM
236
Alpine Global Management
New York
– -$701K -150,000 Closed
BAM
237
Bosun Asset Management
Illinois
– -$621K -132,994 Closed
Man Group
238
Man Group
United Kingdom
– -$611K -130,849 Closed
GCM
239
Graham Capital Management
Connecticut
– -$586K -125,417 Closed
Brown Advisory
240
Brown Advisory
Maryland
– -$536K -114,698 Closed
Chevy Chase Trust
241
Chevy Chase Trust
Maryland
– -$239K -51,243 Closed
Point72 Asset Management
242
Point72 Asset Management
Connecticut
– -$211K -45,100 Closed
CC
243
Centiva Capital
New York
– -$183K -39,086 Closed
XT
244
XTX Topco
Cayman Islands
– -$115K -24,662 Closed
SPA
245
Sherbrooke Park Advisers
New York
– -$114K -24,325 Closed
AWM
246
Apollon Wealth Management
South Carolina
– -$113K -24,201 Closed
CFM
247
Catalyst Funds Management
Australia
– -$101K -21,645 Closed
NRD
248
Nebula Research & Development
New York
– -$96.9K -20,751 Closed
SSG
249
Summit Securities Group
New York
– -$67.7K -14,497 Closed
I
250
InceptionR
California
– -$54.4K -11,639 Closed
7 8 9
10
11

XERS Hedge Fund Activity: Q3 2025 in Review

230 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Xeris Biopharma Holdings (XERS) for Q3 2025, worth a combined $789M — up 87% from $422M a quarter earlier.

Buyers outnumbered sellers: 59 funds opened new XERS positions and 28 closed out — a net gain of 31 holders — while 77 added to existing stakes and 61 trimmed.

The largest buyer was D.E. Shaw & Co, adding an estimated $13.3M. The largest seller was Millennium Management, cutting an estimated $16M.

  • 230 institutional investors held Xeris Biopharma Holdings (XERS) as of Q3 2025, up from 200 in Q2 2025.
  • Funds reported $789M of Xeris Biopharma Holdings stock for Q3 2025, up 87% quarter-over-quarter.
  • 59 funds opened new Xeris Biopharma Holdings positions in Q3 2025 and 28 closed out, a net change of +31 holders.
  • The largest Xeris Biopharma Holdings buyer in Q3 2025 was D.E. Shaw & Co, an estimated $13.3M added.
  • The largest Xeris Biopharma Holdings seller in Q3 2025 was Millennium Management, an estimated $16M sold.

Based on aggregated 13F filings for Q3 2025.