Instil Bio
29 hedge funds and large institutions have $48.9M invested in Instil Bio in 2025 Q4 according to their latest regulatory filings, with 6 funds opening new positions, 7 increasing their positions, 8 reducing their positions, and 11 closing their positions.
0% more funds holding in top 10
Funds holding in top 10: 3 → 3 (0)
1.95% less ownership
Funds ownership: 67.46% → 65.51% (-2%)
13% less repeat investments, than reductions
Existing positions increased: 7 | Existing positions reduced: 8
15% less funds holding
Funds holding: 34 → 29 (-5)
40% less capital invested
Capital invested by funds: $81.3M → $48.9M (-$32.5M)
45% less first-time investments, than exits
New positions opened: 6 | Existing positions closed: 11
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Renaissance Technologies
New York
|
+$1M |
| 2 |
Citadel Advisors
Miami,
Florida
|
+$700K |
| 3 |
Millennium Management
New York
|
+$681K |
| 4 |
Vanguard Group
Malvern,
Pennsylvania
|
+$344K |
| 5 |
A
AlphaQuest
New York
|
+$333K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SAM
Sectoral Asset Management
Montreal,
Quebec, Canada
|
-$2.88M |
| 2 |
BCM
Boxer Capital Management
San Diego,
California
|
-$1.08M |
| 3 |
Macquarie Group
Sydney, NSW 2000,
Australia
|
-$893K |
| 4 |
Marshall Wace
London,
United Kingdom
|
-$802K |
| 5 |
Jane Street
New York
|
-$372K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
EWA
26
EQ Wealth Advisors
Dallas,
Texas
| $440 | +$592 | +40 | New |
|
|
FFA
27
Frazier Financial Advisors
Columbus,
Ohio
| $165 | – | – | – |
|
28
BNP Paribas Financial Markets
Paris,
France
| $77 | -$45.8K | -3,097 | -100% |
|
29
Bank of America
Charlotte,
North Carolina
| $44 | -$8.8K | -595 | -99% |
|
|
SAM
30
Sectoral Asset Management
Montreal,
Quebec, Canada
| – | -$2.88M | -161,380 | Closed |
|
|
BCM
31
Boxer Capital Management
San Diego,
California
| – | -$1.08M | -60,700 | Closed |
|
|
32
Macquarie Group
Sydney, NSW 2000,
Australia
| – | -$893K | -50,000 | Closed |
|
|
33
Marshall Wace
London,
United Kingdom
| – | -$802K | -44,878 | Closed |
|
|
34
Jane Street
New York
| – | -$372K | -20,802 | Closed |
|
35
Northern Trust
Chicago,
Illinois
| – | -$280K | -15,684 | Closed |
|
|
TRCT
36
Tower Research Capital (TRC)
New York
| – | -$56K | -3,134 | Closed |
|
|
BF
37
BOK Financial
Tulsa,
Oklahoma
| – | -$8.11K | -454 | Closed |
|
38
Fidelity Investments
Boston,
Massachusetts
| – | -$94 | -5 | Closed |
|
39
Citigroup
New York
| – | -$18 | -1 | Closed |
|
|
SS
40
SBI Securities
Tokyo,
Japan
| – | -$18 | -1 | Closed |
|
TIL Hedge Fund Activity: Q4 2025 in Review
29 of the 8,256 institutional investors tracked by Wall St. Rank reported a position in Instil Bio (TIL) for Q4 2025, worth a combined $48.9M — down 40% from $81.3M a quarter earlier.
Sellers outnumbered buyers: 11 funds closed out of TIL and 6 opened new positions — a net loss of 5 holders — while 8 trimmed existing stakes and 7 added.
The largest buyer was Renaissance Technologies, opening a new position worth an estimated $1M. The largest seller was Sectoral Asset Management, exiting entirely with an estimated $2.88M sold.
- 29 institutional investors held Instil Bio (TIL) as of Q4 2025, down from 34 in Q3 2025.
- Funds reported $48.9M of Instil Bio stock for Q4 2025, down 40% quarter-over-quarter.
- 6 funds opened new Instil Bio positions in Q4 2025 and 11 closed out, a net change of -5 holders.
- The largest Instil Bio buyer in Q4 2025 was Renaissance Technologies, an estimated $1M added.
- The largest Instil Bio seller in Q4 2025 was Sectoral Asset Management, an estimated $2.88M sold.
Based on aggregated 13F filings for Q4 2025.