Soleno Therapeutics
SLNO
SLNO was delisted on the 15th of May, 2026.
248 hedge funds and large institutions have $3.01B invested in Soleno Therapeutics in 2025 Q4 according to their latest regulatory filings, with 63 funds opening new positions, 102 increasing their positions, 65 reducing their positions, and 49 closing their positions.
88% more call options, than puts
Call options by funds: $112M | Put options by funds: $59.8M
57% more repeat investments, than reductions
Existing positions increased: 102 | Existing positions reduced: 65
29% more first-time investments, than exits
New positions opened: 63 | Existing positions closed: 49
3% more funds holding
Funds holding: 240 → 248 (+8)
1.85% less ownership
Funds ownership: 122.73% → 120.89% (-1.8%)
25% less funds holding in top 10
Funds holding in top 10: 12 → 9 (-3)
32% less capital invested
Capital invested by funds: $4.4B → $3.01B (-$1.4B)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Janus Henderson Group
London,
|
+$61.5M |
| 2 |
Wellington Management Group
Boston,
Massachusetts
|
+$55.4M |
| 3 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
+$54.8M |
| 4 |
WP
Woodline Partners
San Francisco,
California
|
+$46.1M |
| 5 |
RAM
Readystate Asset Management
Chicago,
Illinois
|
+$36.7M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Adage Capital Partners
Boston,
Massachusetts
|
-$94.7M |
| 2 |
VC
Vivo Capital
Palo Alto,
California
|
-$75.8M |
| 3 |
Holocene Advisors
New York
|
-$67.4M |
| 4 |
Westfield Capital Management
Boston,
Massachusetts
|
-$60.8M |
| 5 |
Capital World Investors
Los Angeles,
California
|
-$37.2M |
SLNO Hedge Fund Activity: Q4 2025 in Review
248 of the 8,256 institutional investors tracked by Wall St. Rank reported a position in Soleno Therapeutics (SLNO) for Q4 2025, worth a combined $3.01B — down 32% from $4.4B a quarter earlier.
Buyers outnumbered sellers: 63 funds opened new SLNO positions and 49 closed out — a net gain of 14 holders — while 102 added to existing stakes and 65 trimmed.
The largest buyer was Janus Henderson Group, adding an estimated $61.5M. The largest seller was Adage Capital Partners, exiting entirely with an estimated $94.7M sold.
- 248 institutional investors held Soleno Therapeutics (SLNO) as of Q4 2025, up from 240 in Q3 2025.
- Funds reported $3.01B of Soleno Therapeutics stock for Q4 2025, down 32% quarter-over-quarter.
- 63 funds opened new Soleno Therapeutics positions in Q4 2025 and 49 closed out, a net change of +14 holders.
- The largest Soleno Therapeutics buyer in Q4 2025 was Janus Henderson Group, an estimated $61.5M added.
- The largest Soleno Therapeutics seller in Q4 2025 was Adage Capital Partners, an estimated $94.7M sold.
Based on aggregated 13F filings for Q4 2025.