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Revolution Medicines

386 hedge funds and large institutions have $15.9B invested in Revolution Medicines in 2025 Q4 according to their latest regulatory filings, with 107 funds opening new positions, 135 increasing their positions, 101 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

546% more call options, than puts

Call options by funds: $247M | Put options by funds: $38.2M

174% more first-time investments, than exits

New positions opened: 107 | Existing positions closed: 39

77% more capital invested

Capital invested by funds: $8.96B → $15.9B (+$6.92B)

38% more funds holding in top 10

Funds holding in top 10: 2433 (+9)

34% more repeat investments, than reductions

Existing positions increased: 135 | Existing positions reduced: 101

20% more funds holding

Funds holding: 323386 (+63)

0.46% more ownership

Funds ownership: 102.63%103.09% (+0.46%)

Holders
386
Holders Change
+63
Holders Change %
+19.5%
% of All Funds
4.7%
Holding in Top 10
33
Holding in Top 10 Change
+9
Holding in Top 10 Change %
+37.5%
% of All Funds
0.4%
New
107
Increased
135
Reduced
101
Closed
39
Calls
$247M
Puts
$38.2M
Net Calls
+$208M
Net Calls Change
+$127M
Name Holding Trade Value Shares
Change
Change in
Stake
LC
26
Lunate Capital
United Arab Emirates
$175M
ACA
27
Avoro Capital Advisors
New York
$173M +$142M +2,170,000 New
Ameriprise
28
Ameriprise
Minnesota
$164M +$54.6M +832,098 +68%
PCH
29
Polar Capital Holdings
United Kingdom
$160M +$101M +1,535,686 +321%
LGM
30
Logos Global Management
California
$159M +$16.4M +250,000 +14%
Holocene Advisors
31
Holocene Advisors
New York
$152M -$100M -1,529,335 -44%
Charles Schwab
32
Charles Schwab
California
$134M +$3.17M +48,334 +3%
D.E. Shaw & Co
33
D.E. Shaw & Co
New York
$129M +$52.6M +801,451 +99%
RSCM
34
Rock Springs Capital Management
Maryland
$106M
SL
35
Siren LLC
Connecticut
$106M +$19.1M +291,355 +28%
Citadel Advisors
36
Citadel Advisors
Florida
$104M +$8.02M +122,276 +10%
CP
37
Caligan Partners
New York
$102M +$14.4M +219,651 +21%
IHAM
38
Integral Health Asset Management
New York
$95.6M +$52.5M +800,000 +200%
Dimensional Fund Advisors
39
Dimensional Fund Advisors
Texas
$92.5M -$18.3M -279,172 -19%
JFG
40
Jefferies Financial Group
New York
$90.9M +$74M +1,128,195 +8,678%
Pictet Asset Management
41
Pictet Asset Management
Switzerland
$90.7M -$11.4M -174,620 -13%
Jane Street
42
Jane Street
New York
$86.9M +$32.3M +492,961 +83%
Franklin Resources
43
Franklin Resources
California
$84.4M +$7.13M +108,681 +11%
CS
44
Candriam SCA
Luxembourg
$82.1M +$10.6M +162,268 +19%
HRCM
45
Hood River Capital Management
Florida
$75.3M +$1.14M +17,462 +2%
ACM
46
AH Capital Management
California
$73.4M -$120M -1,827,424 -66%
ACM
47
AIHC Capital Management
$71.7M +$59M +900,392 New
Bank of America
48
Bank of America
North Carolina
$70.1M +$8.26M +125,978 +17%
Northern Trust
49
Northern Trust
Illinois
$67.7M -$605K -9,225 -1%
Millennium Management
50
Millennium Management
New York
$63.7M +$24.4M +371,809 +87%