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MBX

MBX Biosciences
MBX

157 hedge funds and large institutions have $1.57B invested in MBX Biosciences in 2026 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 43 increasing their positions, 47 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

153% more call options, than puts

Call options by funds: $3.68M | Put options by funds: $1.46M

117% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 18

14% more funds holding

Funds holding: 138 → 157 (+19)

2.72% more ownership

Funds ownership: 107.85% → 110.58% (+2.7%)

3% more capital invested

Capital invested by funds: $1.53B → $1.57B (+$40.7M)

9% less repeat investments, than reductions

Existing positions increased: 43 | Existing positions reduced: 47

14% less funds holding in top 10

Funds holding in top 10: 7 → 6 (-1)

Holders
157
Holders Change
+19
Holders Change %
+13.77%
% of All Funds
1.93%
Holding in Top 10
6
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-14.29%
% of All Funds
0.07%
New
39
Increased
43
Reduced
47
Closed
18
Calls
$3.68M
Puts
$1.46M
Net Calls
+$2.22M
Net Calls Change
+$12.1M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$99.3M
2
PCH
Polar Capital Holdings
United Kingdom
+$55.2M
3
AWA
Aaron Wealth Advisors
Illinois
+$37.3M
4
CP
Caligan Partners
New York
+$28.9M
5
B
Braidwell
Connecticut
+$16.1M

Top Sellers

1
EC
EcoR1 Capital
California
-$45.8M
2
Point72 Asset Management
Point72 Asset Management
Connecticut
-$21.5M
3
DTC
Deep Track Capital
Connecticut
-$16.7M
4
DCM
Driehaus Capital Management
Illinois
-$13.3M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$13M
Name Holding Trade Value Shares
Change 		Change in
Stake
EP
151
Essential Partners
California
$448 – – –
FFA
152
Farther Finance Advisors
California
$291 -$34 -1 -10%
MCM
153
MAI Capital Management
Ohio
$209 +$238 +7 New
TWD
154
True Wealth Design
Ohio
$60 – – –
CCA
155
Cygnus Capital Advisors
Georgia
$54 – – –
IA
156
IFP Advisors
Florida
$30 – – –
Point72 Asset Management
157
Point72 Asset Management
Connecticut
– -$21.5M -680,609 Closed
TECP
158
Trails Edge Capital Partners
Georgia
– -$9.94M -315,158 Closed
Balyasny Asset Management
159
Balyasny Asset Management
Illinois
– -$3.78M -119,726 Closed
Jane Street
160
Jane Street
New York
– -$2.94M -86,581 Closed
Renaissance Technologies
161
Renaissance Technologies
New York
– -$1.03M -32,644 Closed
BHCM
162
Brevan Howard Capital Management
Jersey
– -$809K -25,663 Closed
TI
163
Trexquant Investment
Connecticut
– -$765K -24,268 Closed
FRM
164
Fox Run Management
Connecticut
– -$751K -23,820 Closed
GCP
165
GSA Capital Partners
United Kingdom
– -$609K -19,295 Closed
SFCM
166
Seven Fleet Capital Management
California
– -$574K -18,200 Closed
GCM
167
Graham Capital Management
Connecticut
– -$355K -11,254 Closed
Rafferty Asset Management
168
Rafferty Asset Management
New York
– -$256K -8,113 Closed
ProShare Advisors
169
ProShare Advisors
Maryland
– -$227K -7,187 Closed
AC
170
AXQ Capital
New Jersey
– -$204K -6,463 Closed
AB
171
Amalgamated Bank
New York
– -$28K -895 Closed
ACM
172
Aster Capital Management
United Arab Emirates
– -$8.36K -265 Closed
Daiwa Securities Group
173
Daiwa Securities Group
Japan
– -$5K -150 Closed
SS
174
SBI Securities
Japan
– -$284 -9 Closed
C
175
Covestor
United Kingdom
– +$102 +3 New
3 4 5 6
7

MBX Hedge Fund Activity: Q1 2026 in Review

157 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in MBX Biosciences (MBX) for Q1 2026, worth a combined $1.57B — up 2.7% from $1.53B a quarter earlier.

Buyers outnumbered sellers: 39 funds opened new MBX positions and 18 closed out — a net gain of 21 holders — while 43 added to existing stakes and 47 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $99.3M. The largest seller was EcoR1 Capital, cutting an estimated $45.8M.

  • 157 institutional investors held MBX Biosciences (MBX) as of Q1 2026, up from 138 in Q4 2025.
  • Funds reported $1.57B of MBX Biosciences stock for Q1 2026, up 2.7% quarter-over-quarter.
  • 39 funds opened new MBX Biosciences positions in Q1 2026 and 18 closed out, a net change of +21 holders.
  • The largest MBX Biosciences buyer in Q1 2026 was Fidelity Investments, an estimated $99.3M added.
  • The largest MBX Biosciences seller in Q1 2026 was EcoR1 Capital, an estimated $45.8M sold.

Based on aggregated 13F filings for Q1 2026.