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MBX

MBX Biosciences
MBX

138 hedge funds and large institutions have $1.53B invested in MBX Biosciences in 2025 Q4 according to their latest regulatory filings, with 45 funds opening new positions, 53 increasing their positions, 25 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

133% more funds holding in top 10

Funds holding in top 10: 3 → 7 (+4)

112% more repeat investments, than reductions

Existing positions increased: 53 | Existing positions reduced: 25

83% more capital invested

Capital invested by funds: $836M → $1.53B (+$691M)

80% more first-time investments, than exits

New positions opened: 45 | Existing positions closed: 25

17% more funds holding

Funds holding: 118 → 138 (+20)

34.4% less ownership

Funds ownership: 142.26% → 107.85% (-34%)

71% less call options, than puts

Call options by funds: $4.09M | Put options by funds: $14M

Holders
138
Holders Change
+20
Holders Change %
+16.95%
% of All Funds
1.68%
Holding in Top 10
7
Holding in Top 10 Change
+4
Holding in Top 10 Change %
+133.33%
% of All Funds
0.09%
New
45
Increased
53
Reduced
25
Closed
25
Calls
$4.09M
Puts
$14M
Net Calls
-$9.9M
Net Calls Change
+$3.75M

Top Buyers

1
B
Braidwell
Connecticut
+$24.7M
2
BlackRock
BlackRock
New York
+$23.3M
3
EAM
Eventide Asset Management
Massachusetts
+$21.6M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$16.3M
5
State Street
State Street
Massachusetts
+$8.58M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$35.8M
2
KCM
Kynam Capital Management
New Jersey
-$25.8M
3
Franklin Resources
Franklin Resources
California
-$22.9M
4
WP
Woodline Partners
California
-$4.88M
5
BBA
Baker Bros. Advisors
New York
-$4.86M
Name Holding Trade Value Shares
Change 		Change in
Stake
Deutsche Bank
76
Deutsche Bank
Germany
$632K +$221K +9,104 +83%
GCP
77
GSA Capital Partners
United Kingdom
$609K +$468K +19,295 New
KWM
78
Koa Wealth Management
California
$581K -$201K -8,300 -31%
SFCM
79
Seven Fleet Capital Management
California
$574K +$442K +18,200 New
Citigroup
80
Citigroup
New York
$517K +$393K +16,213 +9,108%
MIM
81
MetLife Investment Management
New Jersey
$505K +$121K +5,000 +45%
Fidelity Investments
82
Fidelity Investments
Massachusetts
$497K -$1.29M -53,230 -77%
CUAMC
83
China Universal Asset Management Company
China
$483K +$250K +10,317 +206%
JP Morgan Chase
84
JP Morgan Chase
New York
$462K +$206K +8,470 +137%
Mirae Asset Global ETFs Holdings
85
Mirae Asset Global ETFs Holdings
Hong Kong
$418K +$149K +6,138 +86%
American Century Companies
86
American Century Companies
Missouri
$386K +$297K +12,236 New
Canada Pension Plan Investment Board
87
Canada Pension Plan Investment Board
Ontario, Canada
$366K +$281K +11,600 New
GCM
88
Graham Capital Management
Connecticut
$355K +$273K +11,254 New
BCM
89
Bridgeway Capital Management
Texas
$315K -$102K -4,200 -30%
Group One Trading
90
Group One Trading
Illinois
$297K +$229K +9,428 New
PA
91
Profund Advisors
Maryland
$291K +$224K +9,214 New
Simplex Trading
92
Simplex Trading
Illinois
$281K +$217K +8,925 New
VIA
93
Virtus Investment Advisers
Connecticut
$281K -$41.3K -1,704 -16%
Rafferty Asset Management
94
Rafferty Asset Management
New York
$256K +$197K +8,113 New
SEI Investments
95
SEI Investments
Pennsylvania
$242K +$186K +7,657 New
PFSRSONJ
96
Police & Firemen's Retirement System of New Jersey
New Jersey
$237K +$73.1K +3,011 +67%
ProShare Advisors
97
ProShare Advisors
Maryland
$227K +$174K +7,187 New
Los Angeles Capital Management
98
Los Angeles Capital Management
California
$226K +$251K +10,360 New
IIM
99
INTECH Investment Management
Florida
$216K +$166K +6,858 New
BNP Paribas Financial Markets
100
BNP Paribas Financial Markets
France
$214K +$94.3K +3,888 +134%
2 3
4
5 6

MBX Hedge Fund Activity: Q4 2025 in Review

138 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in MBX Biosciences (MBX) for Q4 2025, worth a combined $1.53B — up 83% from $836M a quarter earlier.

Buyers outnumbered sellers: 45 funds opened new MBX positions and 25 closed out — a net gain of 20 holders — while 53 added to existing stakes and 25 trimmed.

The largest buyer was Braidwell, opening a new position worth an estimated $24.7M. The largest seller was Wellington Management Group, cutting an estimated $35.8M.

  • 138 institutional investors held MBX Biosciences (MBX) as of Q4 2025, up from 118 in Q3 2025.
  • Funds reported $1.53B of MBX Biosciences stock for Q4 2025, up 83% quarter-over-quarter.
  • 45 funds opened new MBX Biosciences positions in Q4 2025 and 25 closed out, a net change of +20 holders.
  • The largest MBX Biosciences buyer in Q4 2025 was Braidwell, an estimated $24.7M added.
  • The largest MBX Biosciences seller in Q4 2025 was Wellington Management Group, an estimated $35.8M sold.

Based on aggregated 13F filings for Q4 2025.