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MBX

MBX Biosciences
MBX

138 hedge funds and large institutions have $1.53B invested in MBX Biosciences in 2025 Q4 according to their latest regulatory filings, with 45 funds opening new positions, 53 increasing their positions, 25 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

133% more funds holding in top 10

Funds holding in top 10: 3 → 7 (+4)

112% more repeat investments, than reductions

Existing positions increased: 53 | Existing positions reduced: 25

83% more capital invested

Capital invested by funds: $836M → $1.53B (+$691M)

80% more first-time investments, than exits

New positions opened: 45 | Existing positions closed: 25

17% more funds holding

Funds holding: 118 → 138 (+20)

34.4% less ownership

Funds ownership: 142.26% → 107.85% (-34%)

71% less call options, than puts

Call options by funds: $4.09M | Put options by funds: $14M

Holders
138
Holders Change
+20
Holders Change %
+16.95%
% of All Funds
1.68%
Holding in Top 10
7
Holding in Top 10 Change
+4
Holding in Top 10 Change %
+133.33%
% of All Funds
0.09%
New
45
Increased
53
Reduced
25
Closed
25
Calls
$4.09M
Puts
$14M
Net Calls
-$9.9M
Net Calls Change
+$3.75M

Top Buyers

1
B
Braidwell
Connecticut
+$24.7M
2
BlackRock
BlackRock
New York
+$23.3M
3
EAM
Eventide Asset Management
Massachusetts
+$21.6M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$16.3M
5
State Street
State Street
Massachusetts
+$8.58M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$35.8M
2
KCM
Kynam Capital Management
New Jersey
-$25.8M
3
Franklin Resources
Franklin Resources
California
-$22.9M
4
WP
Woodline Partners
California
-$4.88M
5
BBA
Baker Bros. Advisors
New York
-$4.86M
Name Holding Trade Value Shares
Change 		Change in
Stake
Schroder Investment Management Group
51
Schroder Investment Management Group
United Kingdom
$2.28M -$243K -10,030 -12%
AWA
52
Aaron Wealth Advisors
Illinois
$2.21M +$485K +20,000 +40%
Manulife (Manufacturers Life Insurance)
53
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$2.15M +$28.5K +1,175 +2%
Morgan Stanley
54
Morgan Stanley
New York
$1.86M +$344K +14,158 +32%
Verition Fund Management
55
Verition Fund Management
Connecticut
$1.82M +$1.4M +57,575 New
ECM
56
ExodusPoint Capital Management
New York
$1.8M -$1.04M -42,995 -43%
Barclays
57
Barclays
United Kingdom
$1.66M +$754K +31,065 +144%
Acadian Asset Management
58
Acadian Asset Management
Massachusetts
$1.53M +$1.06M +43,605 +871%
Squarepoint
59
Squarepoint
New York
$1.47M +$1.13M +46,702 New
PIM
60
Platinum Investment Management
Australia
$1.38M -$627K -25,831 -37%
Bank of America
61
Bank of America
North Carolina
$1.2M +$274K +11,278 +42%
AA
62
ALPS Advisors
Colorado
$1.16M +$486K +20,032 +119%
Creative Planning
63
Creative Planning
Kansas
$1.06M +$119K +4,919 +17%
RhumbLine Advisers
64
RhumbLine Advisers
Massachusetts
$1.05M +$281K +11,599 +53%
Renaissance Technologies
65
Renaissance Technologies
New York
$1.03M +$792K +32,644 New
Wells Fargo
66
Wells Fargo
California
$1.01M +$490K +20,176 +172%
AQR Capital Management
67
AQR Capital Management
Connecticut
$991K +$380K +15,645 +99%
AllianceBernstein
68
AllianceBernstein
Tennessee
$880K +$422K +17,400 +166%
BHCM
69
Brevan Howard Capital Management
Jersey
$809K +$623K +25,663 New
TI
70
Trexquant Investment
Connecticut
$765K +$589K +24,268 New
FRM
71
Fox Run Management
Connecticut
$751K +$578K +23,820 New
Qube Research & Technologies (QRT)
72
Qube Research & Technologies (QRT)
United Kingdom
$732K +$563K +23,213 New
Cerity Partners
73
Cerity Partners
New York
$673K +$517K +21,323 New
Invesco
74
Invesco
Georgia
$669K +$228K +9,415 +80%
XT
75
XTX Topco
Cayman Islands
$635K -$443K -18,239 -48%
1 2
3
4 5

MBX Hedge Fund Activity: Q4 2025 in Review

138 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in MBX Biosciences (MBX) for Q4 2025, worth a combined $1.53B — up 83% from $836M a quarter earlier.

Buyers outnumbered sellers: 45 funds opened new MBX positions and 25 closed out — a net gain of 20 holders — while 53 added to existing stakes and 25 trimmed.

The largest buyer was Braidwell, opening a new position worth an estimated $24.7M. The largest seller was Wellington Management Group, cutting an estimated $35.8M.

  • 138 institutional investors held MBX Biosciences (MBX) as of Q4 2025, up from 118 in Q3 2025.
  • Funds reported $1.53B of MBX Biosciences stock for Q4 2025, up 83% quarter-over-quarter.
  • 45 funds opened new MBX Biosciences positions in Q4 2025 and 25 closed out, a net change of +20 holders.
  • The largest MBX Biosciences buyer in Q4 2025 was Braidwell, an estimated $24.7M added.
  • The largest MBX Biosciences seller in Q4 2025 was Wellington Management Group, an estimated $35.8M sold.

Based on aggregated 13F filings for Q4 2025.