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MBX

MBX Biosciences
MBX

88 hedge funds and large institutions have $420M invested in MBX Biosciences in 2025 Q2 according to their latest regulatory filings, with 21 funds opening new positions, 40 increasing their positions, 14 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed

200% more funds holding in top 10

Funds holding in top 10: 1 → 3 (+2)

186% more repeat investments, than reductions

Existing positions increased: 40 | Existing positions reduced: 14

75% more first-time investments, than exits

New positions opened: 21 | Existing positions closed: 12

60% more capital invested

Capital invested by funds: $263M → $420M (+$157M)

11% more funds holding

Funds holding: 79 → 88 (+9)

3.5% more ownership

Funds ownership: 106.72% → 110.22% (+3.5%)

48% less call options, than puts

Call options by funds: $848K | Put options by funds: $1.63M

Holders
88
Holders Change
+9
Holders Change %
+11.39%
% of All Funds
1.16%
Holding in Top 10
3
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+200%
% of All Funds
0.04%
New
21
Increased
40
Reduced
14
Closed
12
Calls
$848K
Puts
$1.63M
Net Calls
-$779K
Net Calls Change
-$779K

Top Buyers

Rank Fund Capital Flow
1
Point72 Asset Management
Point72 Asset Management
Connecticut
+$8.8M
2
Millennium Management
Millennium Management
New York
+$6.08M
3
PHP
Parkman Healthcare Partners
Connecticut
+$5.54M
4
SSA
Schonfeld Strategic Advisors
New York
+$4.39M
5
Vanguard Group
Vanguard Group
Pennsylvania
+$3.85M

Top Sellers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
-$11.5M
2
DTC
Deep Track Capital
Connecticut
-$8.46M
3
Wellington Management Group
Wellington Management Group
Massachusetts
-$3.79M
4
JP Morgan Chase
JP Morgan Chase
New York
-$1.97M
5
AAA
Affinity Asset Advisors
New York
-$1.29M
Name Holding Trade Value Shares
Change 		Change in
Stake
SAM
26
Sectoral Asset Management
Quebec, Canada
$2.19M +$1.95M +191,825 New
TD Asset Management
27
TD Asset Management
Ontario, Canada
$1.95M +$202K +19,800 +13%
SC
28
Stempoint Capital
New York
$1.61M +$452K +44,406 +46%
Northern Trust
29
Northern Trust
Illinois
$1.32M +$194K +19,087 +20%
PIM
30
Platinum Investment Management
Australia
$1.29M -$746K -73,189 -39%
Charles Schwab
31
Charles Schwab
California
$1.23M +$132K +12,937 +14%
Manulife (Manufacturers Life Insurance)
32
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$994K +$377K +36,987 +74%
Walleye Capital
33
Walleye Capital
New York
$803K +$386K +37,843 +116%
EAM
34
Exome Asset Management
New York
$720K -$714K -70,037 -53%
Fidelity Investments
35
Fidelity Investments
Massachusetts
$700K +$174K +17,093 +39%
Barclays
36
Barclays
United Kingdom
$668K +$476K +46,723 +395%
AWA
37
Aaron Wealth Advisors
Illinois
$571K – – –
RCAP
38
Resolute Capital Asset Partners
Colorado
$567K +$506K +49,670 New
Bank of America
39
Bank of America
North Carolina
$484K +$146K +14,297 +51%
Bank of New York Mellon
40
Bank of New York Mellon
New York
$434K +$144K +14,122 +59%
Rockefeller Capital Management
41
Rockefeller Capital Management
New York
$389K +$348K +34,135 New
KWM
42
Koa Wealth Management
California
$362K +$126K +12,356 +64%
UBS Group
43
UBS Group
Switzerland
$353K +$35.3K +3,468 +13%
BCM
44
Bridgeway Capital Management
Texas
$333K +$297K +29,200 New
Susquehanna International Group
45
Susquehanna International Group
Pennsylvania
$315K +$142K +13,972 +102%
Morgan Stanley
46
Morgan Stanley
New York
$274K -$923K -90,602 -79%
RhumbLine Advisers
47
RhumbLine Advisers
Massachusetts
$270K +$152K +14,950 +172%
N
48
Nuveen
North Carolina
$253K +$78.2K +7,672 +53%
AA
49
ALPS Advisors
Colorado
$206K -$81.4K -7,986 -31%
AQR Capital Management
50
AQR Capital Management
Connecticut
$205K +$183K +18,001 New
1
2
3 4

MBX Hedge Fund Activity: Q2 2025 in Review

88 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in MBX Biosciences (MBX) for Q2 2025, worth a combined $420M — up 60% from $263M a quarter earlier.

Buyers outnumbered sellers: 21 funds opened new MBX positions and 12 closed out — a net gain of 9 holders — while 40 added to existing stakes and 14 trimmed.

The largest buyer was Point72 Asset Management, adding an estimated $8.8M. The largest seller was RA Capital Management, cutting an estimated $11.5M.

  • 88 institutional investors held MBX Biosciences (MBX) as of Q2 2025, up from 79 in Q1 2025.
  • Funds reported $420M of MBX Biosciences stock for Q2 2025, up 60% quarter-over-quarter.
  • 21 funds opened new MBX Biosciences positions in Q2 2025 and 12 closed out, a net change of +9 holders.
  • The largest MBX Biosciences buyer in Q2 2025 was Point72 Asset Management, an estimated $8.8M added.
  • The largest MBX Biosciences seller in Q2 2025 was RA Capital Management, an estimated $11.5M sold.

Based on aggregated 13F filings for Q2 2025.