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MAZE

Maze Therapeutics
MAZE

143 hedge funds and large institutions have $2B invested in Maze Therapeutics in 2025 Q4 according to their latest regulatory filings, with 57 funds opening new positions, 46 increasing their positions, 20 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

613% more first-time investments, than exits

New positions opened: 57 | Existing positions closed: 8

130% more repeat investments, than reductions

Existing positions increased: 46 | Existing positions reduced: 20

80% more capital invested

Capital invested by funds: $1.11B → $2B (+$889M)

52% more funds holding

Funds holding: 94 → 143 (+49)

25% more funds holding in top 10

Funds holding in top 10: 12 → 15 (+3)

2.52% more ownership

Funds ownership: 97.99% → 100.51% (+2.5%)

Holders
143
Holders Change
+49
Holders Change %
+52.13%
% of All Funds
1.74%
Holding in Top 10
15
Holding in Top 10 Change
+3
Holding in Top 10 Change %
+25%
% of All Funds
0.18%
New
57
Increased
46
Reduced
20
Closed
8
Calls
$1.19M
Puts
–
Net Calls
+$1.19M
Net Calls Change
+$1.96M

Top Buyers

Rank Fund Capital Flow
1
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$82.2M
2
BlackRock
BlackRock
New York
+$33.4M
3
BG
Bellevue Group
Switzerland
+$30.5M
4
CP
Caligan Partners
New York
+$18.9M
5
Citadel Advisors
Citadel Advisors
Florida
+$15.4M

Top Sellers

Rank Fund Capital Flow
1
TGI
TRV GP IV
Massachusetts
-$55M
2
MCMC
Matrix Capital Management Company
New Hampshire
-$40.3M
3
AI
Alphabet Inc
California
-$35.2M
4
LGM
Logos Global Management
California
-$9.53M
5
Balyasny Asset Management
Balyasny Asset Management
Illinois
-$8.06M
Name Holding Trade Value Shares
Change 		Change in
Stake
Wells Fargo
76
Wells Fargo
California
$995K +$317K +9,229 +62%
RhumbLine Advisers
77
RhumbLine Advisers
Massachusetts
$983K +$94.9K +2,761 +13%
GGHC
78
Gilder Gagnon Howe & Co
New York
$965K +$800K +23,282 New
Russell Investments Group
79
Russell Investments Group
United Kingdom
$934K +$709K +20,638 +1,082%
Verition Fund Management
80
Verition Fund Management
Connecticut
$933K +$774K +22,512 New
American Century Companies
81
American Century Companies
Missouri
$891K +$739K +21,509 New
JP Morgan Chase
82
JP Morgan Chase
New York
$829K +$416K +12,117 +154%
ACP
83
Acuta Capital Partners
California
$829K +$687K +20,000 New
Bank of America
84
Bank of America
North Carolina
$762K +$303K +8,807 +92%
Deutsche Bank
85
Deutsche Bank
Germany
$643K +$228K +6,637 +75%
Los Angeles Capital Management
86
Los Angeles Capital Management
California
$635K +$656K +19,100 New
Two Sigma Advisers
87
Two Sigma Advisers
New York
$613K +$509K +14,800 New
PR
88
PSP Research
Pennsylvania
$525K +$436K +12,672 New
MIM
89
MetLife Investment Management
New Jersey
$489K – – –
CUAMC
90
China Universal Asset Management Company
China
$474K +$324K +9,441 +472%
Citigroup
91
Citigroup
New York
$466K +$377K +10,983 +4,083%
SO
92
STRS Ohio
Ohio
$464K -$230K -6,700 -37%
FWP
93
Falcon Wealth Planning
California
$416K +$345K +10,030 New
SG Americas Securities
94
SG Americas Securities
New York
$352K +$120K +3,478 +69%
Two Sigma Investments
95
Two Sigma Investments
New York
$300K -$134K -3,905 -35%
Manulife (Manufacturers Life Insurance)
96
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$286K +$237K +6,897 New
VIA
97
Virtus Investment Advisers
Connecticut
$284K -$53.3K -1,551 -18%
New York State Common Retirement Fund
98
New York State Common Retirement Fund
New York
$278K – – –
PAP
99
Persistent Asset Partners
Hong Kong
$274K +$227K +6,605 New
IIM
100
INTECH Investment Management
Florida
$267K +$221K +6,443 New
2 3
4
5 6

MAZE Hedge Fund Activity: Q4 2025 in Review

143 of the 8,224 institutional investors tracked by Wall St. Rank reported a position in Maze Therapeutics (MAZE) for Q4 2025, worth a combined $2B — up 80% from $1.11B a quarter earlier.

Buyers outnumbered sellers: 57 funds opened new MAZE positions and 8 closed out — a net gain of 49 holders — while 46 added to existing stakes and 20 trimmed.

The largest buyer was Janus Henderson Group, adding an estimated $82.2M. The largest seller was TRV GP IV, cutting an estimated $55M.

  • 143 institutional investors held Maze Therapeutics (MAZE) as of Q4 2025, up from 94 in Q3 2025.
  • Funds reported $2B of Maze Therapeutics stock for Q4 2025, up 80% quarter-over-quarter.
  • 57 funds opened new Maze Therapeutics positions in Q4 2025 and 8 closed out, a net change of +49 holders.
  • The largest Maze Therapeutics buyer in Q4 2025 was Janus Henderson Group, an estimated $82.2M added.
  • The largest Maze Therapeutics seller in Q4 2025 was TRV GP IV, an estimated $55M sold.

Based on aggregated 13F filings for Q4 2025.