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MAZE

Maze Therapeutics
MAZE

143 hedge funds and large institutions have $2B invested in Maze Therapeutics in 2025 Q4 according to their latest regulatory filings, with 57 funds opening new positions, 46 increasing their positions, 20 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

613% more first-time investments, than exits

New positions opened: 57 | Existing positions closed: 8

130% more repeat investments, than reductions

Existing positions increased: 46 | Existing positions reduced: 20

80% more capital invested

Capital invested by funds: $1.11B → $2B (+$889M)

52% more funds holding

Funds holding: 94 → 143 (+49)

25% more funds holding in top 10

Funds holding in top 10: 12 → 15 (+3)

2.52% more ownership

Funds ownership: 97.99% → 100.51% (+2.5%)

Holders
143
Holders Change
+49
Holders Change %
+52.13%
% of All Funds
1.74%
Holding in Top 10
15
Holding in Top 10 Change
+3
Holding in Top 10 Change %
+25%
% of All Funds
0.18%
New
57
Increased
46
Reduced
20
Closed
8
Calls
$1.19M
Puts
–
Net Calls
+$1.19M
Net Calls Change
+$1.96M

Top Buyers

Rank Fund Capital Flow
1
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$82.2M
2
BlackRock
BlackRock
New York
+$33.4M
3
BG
Bellevue Group
Switzerland
+$30.5M
4
CP
Caligan Partners
New York
+$18.9M
5
Citadel Advisors
Citadel Advisors
Florida
+$15.4M

Top Sellers

Rank Fund Capital Flow
1
TGI
TRV GP IV
Massachusetts
-$55M
2
MCMC
Matrix Capital Management Company
New Hampshire
-$40.3M
3
AI
Alphabet Inc
California
-$35.2M
4
LGM
Logos Global Management
California
-$9.53M
5
Balyasny Asset Management
Balyasny Asset Management
Illinois
-$8.06M
Name Holding Trade Value Shares
Change 		Change in
Stake
IHAM
51
Integral Health Asset Management
New York
$4.14M +$3.44M +100,000 New
Ameriprise
52
Ameriprise
Minnesota
$4.01M +$3.32M +96,688 New
FCMV
53
Foresite Capital Management V
California
$3.58M – – –
MB
54
MPM BioImpact
Massachusetts
$3.36M +$2.79M +81,145 New
SFM
55
Sphera Funds Management
Israel
$2.98M -$2.84M -82,500 -53%
SC
56
SummitTX Capital
Texas
$2.88M +$2.39M +69,560 New
Raymond James Financial
57
Raymond James Financial
Florida
$2.81M +$2.33M +67,718 New
Wellington Management Group
58
Wellington Management Group
Massachusetts
$2.54M +$2.1M +61,205 New
Bank of New York Mellon
59
Bank of New York Mellon
New York
$2.5M +$522K +15,196 +34%
Osaic Holdings
60
Osaic Holdings
Arizona
$2.48M +$1M +29,237 +96%
N
61
Nuveen
North Carolina
$2.37M +$926K +26,954 +89%
Franklin Resources
62
Franklin Resources
California
$2.29M +$1.27M +37,031 +203%
TI
63
Trexquant Investment
Connecticut
$2.17M +$1.8M +52,459 New
SGM
64
Seven Grand Managers
New York
$2.07M +$1.72M +50,000 New
SSA
65
Schonfeld Strategic Advisors
New York
$2M -$2.26M -65,849 -58%
Barclays
66
Barclays
United Kingdom
$1.64M +$412K +11,992 +44%
D.E. Shaw & Co
67
D.E. Shaw & Co
New York
$1.4M +$1.16M +33,694 New
AllianceBernstein
68
AllianceBernstein
Tennessee
$1.38M -$924K -26,880 -45%
XT
69
XTX Topco
Cayman Islands
$1.37M +$212K +6,154 +23%
Mirae Asset Global ETFs Holdings
70
Mirae Asset Global ETFs Holdings
Hong Kong
$1.3M +$764K +22,217 +245%
CCM
71
Cinctive Capital Management
New York
$1.21M +$1M +29,134 New
UBS Group
72
UBS Group
Switzerland
$1.19M +$31.1K +905 +3%
AQR Capital Management
73
AQR Capital Management
Connecticut
$1.14M -$6.05K -176 -0.6%
Renaissance Technologies
74
Renaissance Technologies
New York
$1.12M -$2.03M -59,000 -69%
Tudor Investment Corp
75
Tudor Investment Corp
Connecticut
$997K +$827K +24,059 New
1 2
3
4 5

MAZE Hedge Fund Activity: Q4 2025 in Review

143 of the 8,224 institutional investors tracked by Wall St. Rank reported a position in Maze Therapeutics (MAZE) for Q4 2025, worth a combined $2B — up 80% from $1.11B a quarter earlier.

Buyers outnumbered sellers: 57 funds opened new MAZE positions and 8 closed out — a net gain of 49 holders — while 46 added to existing stakes and 20 trimmed.

The largest buyer was Janus Henderson Group, adding an estimated $82.2M. The largest seller was TRV GP IV, cutting an estimated $55M.

  • 143 institutional investors held Maze Therapeutics (MAZE) as of Q4 2025, up from 94 in Q3 2025.
  • Funds reported $2B of Maze Therapeutics stock for Q4 2025, up 80% quarter-over-quarter.
  • 57 funds opened new Maze Therapeutics positions in Q4 2025 and 8 closed out, a net change of +49 holders.
  • The largest Maze Therapeutics buyer in Q4 2025 was Janus Henderson Group, an estimated $82.2M added.
  • The largest Maze Therapeutics seller in Q4 2025 was TRV GP IV, an estimated $55M sold.

Based on aggregated 13F filings for Q4 2025.