GH Research
GHRS
53 hedge funds and large institutions have $591M invested in GH Research in 2025 Q4 according to their latest regulatory filings, with 15 funds opening new positions, 18 increasing their positions, 14 reducing their positions, and 8 closing their positions.
88% more first-time investments, than exits
New positions opened: 15 | Existing positions closed: 8
50% more funds holding in top 10
Funds holding in top 10: 2 → 3 (+1)
29% more repeat investments, than reductions
Existing positions increased: 18 | Existing positions reduced: 14
13% more funds holding
Funds holding: 47 → 53 (+6)
3.9% more ownership
Funds ownership: 85.59% → 89.5% (+3.9%)
4% less capital invested
Capital invested by funds: $618M → $591M (-$26.8M)
45% less call options, than puts
Call options by funds: $547K | Put options by funds: $991K
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
LCM
Lynx1 Capital Management
San Juan,
Puerto Rico
|
+$24.6M |
| 2 |
ACA
Avoro Capital Advisors
New York
|
+$24.5M |
| 3 |
BlackRock
New York
|
+$5.13M |
| 4 |
RI
RTW Investments
New York
|
+$4.96M |
| 5 |
TCA
Troluce Capital Advisors
Dorado,
Puerto Rico
|
+$4.45M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
-$17.9M |
| 2 |
CAM
Cormorant Asset Management
Boston,
Massachusetts
|
-$8.4M |
| 3 |
SC
Stempoint Capital
New York
|
-$7.8M |
| 4 |
Millennium Management
New York
|
-$7.73M |
| 5 |
Fidelity Investments
Boston,
Massachusetts
|
-$2.6M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
51
Daiwa Securities Group
Tokyo,
Japan
| $3K | +$2.82K | +207 | New |
|
52
Simplex Trading
Chicago,
Illinois
| $609 | -$56.7K | -4,161 | -99% |
|
|
SS
53
SBI Securities
Tokyo,
Japan
| $254 | +$272 | +20 | New |
|
|
DTC
54
Deep Track Capital
Greenwich,
Connecticut
| – | -$17.9M | -1,250,000 | Closed |
|
|
SC
55
Stempoint Capital
New York
| – | -$7.8M | -545,275 | Closed |
|
56
Point72 Asset Management
Stamford,
Connecticut
| – | -$1.1M | -76,958 | Closed |
|
57
Squarepoint
New York
| – | -$516K | -36,103 | Closed |
|
|
TCM
58
Tang Capital Management
San Diego,
California
| – | -$344K | -24,030 | Closed |
|
59
Man Group
London,
United Kingdom
| – | -$315K | -22,060 | Closed |
|
|
FFA
60
Farther Finance Advisors
San Francisco,
California
| – | -$2.86K | -200 | Closed |
|
61
Group One Trading
Chicago,
Illinois
| – | -$1.36K | -100 | Closed |
|
GHRS Hedge Fund Activity: Q4 2025 in Review
53 of the 8,225 institutional investors tracked by Wall St. Rank reported a position in GH Research (GHRS) for Q4 2025, worth a combined $591M — down 4.3% from $618M a quarter earlier.
Buyers outnumbered sellers: 15 funds opened new GHRS positions and 8 closed out — a net gain of 7 holders — while 18 added to existing stakes and 14 trimmed.
The largest buyer was Lynx1 Capital Management, adding an estimated $24.6M. The largest seller was Deep Track Capital, exiting entirely with an estimated $17.9M sold.
- 53 institutional investors held GH Research (GHRS) as of Q4 2025, up from 47 in Q3 2025.
- Funds reported $591M of GH Research stock for Q4 2025, down 4.3% quarter-over-quarter.
- 15 funds opened new GH Research positions in Q4 2025 and 8 closed out, a net change of +7 holders.
- The largest GH Research buyer in Q4 2025 was Lynx1 Capital Management, an estimated $24.6M added.
- The largest GH Research seller in Q4 2025 was Deep Track Capital, an estimated $17.9M sold.
Based on aggregated 13F filings for Q4 2025.