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GBIO

Generation Bio
GBIO

Delisted

GBIO was delisted on the 6th of February, 2026.

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48 hedge funds and large institutions have $24.5M invested in Generation Bio in 2025 Q4 according to their latest regulatory filings, with 11 funds opening new positions, 10 increasing their positions, 15 reducing their positions, and 4 closing their positions.

New
Increased
Maintained
Reduced
Closed

175% more first-time investments, than exits

New positions opened: 11 | Existing positions closed: 4

100% more funds holding in top 10

Funds holding in top 10: 1 → 2 (+1)

17% more funds holding

Funds holding: 41 → 48 (+7)

5.07% more ownership

Funds ownership: 58.93% → 64% (+5.1%)

1% more capital invested

Capital invested by funds: $24.2M → $24.5M (+$283K)

33% less repeat investments, than reductions

Existing positions increased: 10 | Existing positions reduced: 15

Holders
48
Holders Change
+7
Holders Change %
+17.07%
% of All Funds
0.58%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.02%
New
11
Increased
10
Reduced
15
Closed
4
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
OM
Opaleye Management
Massachusetts
+$1.75M
2
RC
Rangeley Capital
Connecticut
+$555K
3
DS
DRW Securities
Illinois
+$247K
4
Two Sigma Investments
Two Sigma Investments
New York
+$215K
5
DAM
Deltec Asset Management
New York
+$184K

Top Sellers

Rank Fund Capital Flow
1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$2.07M
2
BBA
Baker Bros. Advisors
New York
-$1.19M
3
CF
Cantor Fitzgerald
New York
-$606K
4
SL
Siren LLC
Connecticut
-$539K
5
Marshall Wace
Marshall Wace
United Kingdom
-$442K
Name Holding Trade Value Shares
Change 		Change in
Stake
ACM
26
ADAR1 Capital Management
Texas
$126K – – –
State Street
27
State Street
Massachusetts
$114K – – –
SC
28
Shay Capital
New York
$113K +$53.2K +9,425 +91%
CL
29
CSS LLC
Illinois
$99.2K +$98.6K +17,464 New
Northern Trust
30
Northern Trust
Illinois
$96.9K +$21.2K +3,752 +28%
PAI
31
Palo Alto Investors
California
$85.5K – – –
Manulife (Manufacturers Life Insurance)
32
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$80.5K – – –
XT
33
XTX Topco
Cayman Islands
$74.5K +$10K +1,778 +16%
Two Sigma Advisers
34
Two Sigma Advisers
New York
$67.8K +$67.4K +11,930 New
SFCM
35
Seven Fleet Capital Management
California
$30.5K +$30.4K +5,376 New
ACM
36
Accent Capital Management
Ohio
$17K -$68 -12 -32%
Fidelity Investments
37
Fidelity Investments
Massachusetts
$14.9K -$58.8K -10,414 -80%
Royal Bank of Canada
38
Royal Bank of Canada
Ontario, Canada
$6K -$548 -97 -9%
JP Morgan Chase
39
JP Morgan Chase
New York
$3.91K +$11 +2 +0.3%
Rockefeller Capital Management
40
Rockefeller Capital Management
New York
$2.84K +$847 +150 +43%
SCM
41
Sterling Capital Management
North Carolina
$1.1K – – –
BNP Paribas Financial Markets
42
BNP Paribas Financial Markets
France
$835 -$40 -7 -5%
SS
43
SBI Securities
Japan
$301 – – –
Wells Fargo
44
Wells Fargo
California
$284 – – –
Optiver Holding
45
Optiver Holding
Netherlands
$11 -$17 -3 -60%
SAM
46
Smartleaf Asset Management
Massachusetts
$6 +$6 +1 New
BBA
47
Baker Bros. Advisors
New York
– -$1.19M -194,493 Closed
CF
48
Cantor Fitzgerald
New York
– -$606K -99,000 Closed
Osaic Holdings
49
Osaic Holdings
Arizona
– -$4.95K -15,459 Closed
Citigroup
50
Citigroup
New York
– -$4.09K -668 Closed
1
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GBIO Hedge Fund Activity: Q4 2025 in Review

48 of the 8,243 institutional investors tracked by Wall St. Rank reported a position in Generation Bio (GBIO) for Q4 2025, worth a combined $24.5M — up 1.2% from $24.2M a quarter earlier.

Buyers outnumbered sellers: 11 funds opened new GBIO positions and 4 closed out — a net gain of 7 holders — while 10 added to existing stakes and 15 trimmed.

The largest buyer was Opaleye Management, opening a new position worth an estimated $1.75M. The largest seller was T. Rowe Price Associates, cutting an estimated $2.07M.

  • 48 institutional investors held Generation Bio (GBIO) as of Q4 2025, up from 41 in Q3 2025.
  • Funds reported $24.5M of Generation Bio stock for Q4 2025, up 1.2% quarter-over-quarter.
  • 11 funds opened new Generation Bio positions in Q4 2025 and 4 closed out, a net change of +7 holders.
  • The largest Generation Bio buyer in Q4 2025 was Opaleye Management, an estimated $1.75M added.
  • The largest Generation Bio seller in Q4 2025 was T. Rowe Price Associates, an estimated $2.07M sold.

Based on aggregated 13F filings for Q4 2025.