Clene
CLNN
28 hedge funds and large institutions have $11.4M invested in Clene in 2025 Q4 according to their latest regulatory filings, with 3 funds opening new positions, 12 increasing their positions, 4 reducing their positions, and 4 closing their positions.
200% more repeat investments, than reductions
Existing positions increased: 12 | Existing positions reduced: 4
141% more capital invested
Capital invested by funds: $4.72M → $11.4M (+$6.65M)
10.96% more ownership
Funds ownership: 7.78% → 18.75% (+11%)
3% less funds holding
Funds holding: 29 → 28 (-1)
25% less first-time investments, than exits
New positions opened: 3 | Existing positions closed: 4
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
BCM
Boxer Capital Management
San Diego,
California
|
+$1.66M |
| 2 |
Ensign Peak Advisors
Salt Lake City,
Utah
|
+$826K |
| 3 |
PEAK6
Chicago,
Illinois
|
+$415K |
| 4 |
BlackRock
New York
|
+$247K |
| 5 |
SM
Scoggin Management
New York
|
+$208K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Renaissance Technologies
New York
|
-$183K |
| 2 |
Marshall Wace
London,
United Kingdom
|
-$137K |
| 3 |
SS
SBI Securities
Tokyo,
Japan
|
-$125K |
| 4 |
AAP
Arax Advisory Partners
Denver,
Colorado
|
-$21.9K |
| 5 |
Northern Trust
Chicago,
Illinois
|
-$5.47K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
SS
26
SBI Securities
Tokyo,
Japan
| $147 | -$125K | -15,000 | -100% |
|
27
BNP Paribas Financial Markets
Paris,
France
| $135 | – | – | – |
|
28
US Bancorp
Minneapolis,
Minnesota
| $117 | – | – | – |
|
|
29
Renaissance Technologies
New York
| – | -$183K | -30,440 | Closed |
|
|
30
Marshall Wace
London,
United Kingdom
| – | -$137K | -22,709 | Closed |
|
|
PS
31
Principal Securities
Des Moines,
Iowa
| – | -$90 | -15 | Closed |
|
32
Citigroup
New York
| – | -$6 | -1 | Closed |
|
CLNN Hedge Fund Activity: Q4 2025 in Review
28 of the 8,245 institutional investors tracked by Wall St. Rank reported a position in Clene (CLNN) for Q4 2025, worth a combined $11.4M — up 141% from $4.72M a quarter earlier.
Sellers outnumbered buyers: 4 funds closed out of CLNN and 3 opened new positions — a net loss of 1 holder — while 4 trimmed existing stakes and 12 added.
The largest buyer was Boxer Capital Management, opening a new position worth an estimated $1.66M. The largest seller was Renaissance Technologies, exiting entirely with an estimated $183K sold.
- 28 institutional investors held Clene (CLNN) as of Q4 2025, down from 29 in Q3 2025.
- Funds reported $11.4M of Clene stock for Q4 2025, up 141% quarter-over-quarter.
- 3 funds opened new Clene positions in Q4 2025 and 4 closed out, a net change of -1 holder.
- The largest Clene buyer in Q4 2025 was Boxer Capital Management, an estimated $1.66M added.
- The largest Clene seller in Q4 2025 was Renaissance Technologies, an estimated $183K sold.
Based on aggregated 13F filings for Q4 2025.